scPDB - Distribution of Binding site Similarity values of 2gqg entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2gqg	1N1	Tyrosine-protein kinase ABL1	2.7.10.2

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2gqg	1N1	Tyrosine-protein kinase ABL1	2.7.10.2	1.000
3ppk	FNI	Serine/threonine-protein kinase B-raf	2.7.11.1	0.524
5bvw	1N1	Epithelial discoidin domain-containing receptor 1	2.7.10.1	0.524
3b8q	900	Vascular endothelial growth factor receptor 2	2.7.10.1	0.488
3ac5	KZM	Tyrosine-protein kinase Lck	2.7.10.2	0.487
3prf	FP3	Serine/threonine-protein kinase B-raf	2.7.11.1	0.486
4tyj	0LI	Fibroblast growth factor receptor 4	2.7.10.1	0.484
4fk3	325	Serine/threonine-protein kinase B-raf	2.7.11.1	0.481
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.480
2g2h	P16	Tyrosine-protein kinase ABL1	2.7.10.2	0.474
4j53	1J4	Serine/threonine-protein kinase PLK1	2.7.11.21	0.473
4nie	NBH	Nuclear receptor ROR-gamma	/	0.472
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.471
1uyd	PU8	Heat shock protein HSP 90-alpha	/	0.471
3bi6	396	Wee1-like protein kinase	2.7.10.2	0.471
1d4a	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.470
3o6o	94M	Heat shock protein 83	/	0.468
4cjx	9L9	C-1-tetrahydrofolate synthase, cytoplasmic, putative	/	0.468
3be2	RAJ	Vascular endothelial growth factor receptor 2	2.7.10.1	0.467
4gk2	L66	Ephrin type-A receptor 3	2.7.10.1	0.465
2j3j	HC4	NADPH-dependent oxidoreductase 2-alkenal reductase	1.3.1.74	0.463
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.463
3a1n	NAD	NDP-sugar epimerase	/	0.463
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.463
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.463
4ocv	ANP	Aminoglycoside phosphotransferase	/	0.463
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.462
3zei	AWH	O-acetylserine sulfhydrylase	/	0.461
4xey	1N1	Tyrosine-protein kinase ABL1	2.7.10.2	0.461
1jtq	LY3	Thymidylate synthase	/	0.460
2uag	UMA	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.460
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.460
3ds6	A17	Mitogen-activated protein kinase 14	/	0.460
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.459
2rl5	2RL	Vascular endothelial growth factor receptor 2	2.7.10.1	0.459
3ac1	KZI	Tyrosine-protein kinase Lck	2.7.10.2	0.458
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.458
4b4w	9L9	Bifunctional protein FolD	/	0.457
1fml	RTL	Retinol dehydratase	/	0.456
1pq9	44B	Oxysterols receptor LXR-beta	/	0.456
2bdj	HET	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.456
3qri	919	Tyrosine-protein kinase ABL1	2.7.10.2	0.456
4nh8	2LC	Heat shock protein HSP 90-alpha	/	0.456
1jpa	ANP	Ephrin type-B receptor 2	2.7.10.1	0.455
3vo3	0KF	Vascular endothelial growth factor receptor 2	2.7.10.1	0.455
3vt9	YI4	Vitamin D3 receptor	/	0.455
1nzd	UPG	DNA beta-glucosyltransferase	/	0.454
2vbd	V10	Isopenicillin N synthase	1.21.3.1	0.454
3e92	G6A	Mitogen-activated protein kinase 14	/	0.454
4ewn	0VR	Imidazole glycerol phosphate synthase subunit HisF	4.1.3	0.454
1hdc	CBO	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	1.1.1.53	0.453
1uye	PU9	Heat shock protein HSP 90-alpha	/	0.453
1u4d	DBQ	Activated CDC42 kinase 1	/	0.452
2f4j	VX6	Tyrosine-protein kinase ABL1	2.7.10.2	0.451
3qlg	1N1	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.451
2fb8	215	Serine/threonine-protein kinase B-raf	2.7.11.1	0.450
2tsc	CB3	Thymidylate synthase	/	0.450
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.450
2z7h	GG3	Geranylgeranyl pyrophosphate synthase	/	0.450
3e5a	VX6	Aurora kinase A	2.7.11.1	0.450
3lfe	Z84	Mitogen-activated protein kinase 14	/	0.450
2bdf	24A	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.449
2v13	C40	Renin	3.4.23.15	0.449
3eks	CY9	Actin-5C	/	0.449
4at3	LTI	BDNF/NT-3 growth factors receptor	2.7.10.1	0.449
4eh8	IRG	Mitogen-activated protein kinase 14	/	0.449
4v01	0LI	Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b	/	0.449
1i59	ANP	Chemotaxis protein CheA	2.7.13.3	0.448
2g1r	3IG	Renin	3.4.23.15	0.448
3jsi	WTC	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.448
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.448
4u07	ATP	Adenosine monophosphate-protein transferase FICD	2.7.7.n1	0.448
1h69	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.447
3hll	I45	Mitogen-activated protein kinase 14	/	0.447
3itz	P66	Mitogen-activated protein kinase 14	/	0.447
3vt7	VDX	Vitamin D3 receptor	/	0.447
3vtd	TKD	Vitamin D3 receptor	/	0.447
1qbg	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.446
4rvg	TYD	D-mycarose 3-C-methyltransferase	/	0.446
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
1nce	CB3	Thymidylate synthase	/	0.445
2nmt	MIM	Glycylpeptide N-tetradecanoyltransferase	2.3.1.97	0.445
3cic	316	Beta-secretase 1	3.4.23.46	0.445
3g5s	FAD	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	/	0.445
3g70	A5T	Renin	3.4.23.15	0.445
4jqh	1MF	Alr2278 protein	/	0.445
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.444
2cy2	ACO	Probable acetyltransferase	/	0.444
2iko	7IG	Renin	3.4.23.15	0.444
3flw	FLW	Mitogen-activated protein kinase 14	/	0.444
3lpi	Z74	Beta-secretase 1	3.4.23.46	0.444
3lpk	Z76	Beta-secretase 1	3.4.23.46	0.444
3v2u	ATP	Protein GAL3	/	0.444
4jia	1K3	Tyrosine-protein kinase JAK2	/	0.444
5a4k	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.444
1gg5	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.443
1kce	CB3	Thymidylate synthase	/	0.443
2g24	7IG	Renin	3.4.23.15	0.443
3aty	FMN	Prostaglandin F2a synthase	/	0.443
3cr0	809	Wee1-like protein kinase	2.7.10.2	0.443
3el7	PD3	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.443
1kbq	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.442
2ges	COK	Pantothenate kinase	2.7.1.33	0.442
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.442
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.442
2z2w	770	Wee1-like protein kinase	2.7.10.2	0.442
2zva	1N1	Tyrosine-protein kinase Lyn	2.7.10.2	0.442
3l0l	HC3	Nuclear receptor ROR-gamma	/	0.442
3vs5	VSG	Tyrosine-protein kinase HCK	2.7.10.2	0.442
4agd	B49	Vascular endothelial growth factor receptor 2	2.7.10.1	0.442
4elb	34R	Dihydrofolate reductase	/	0.442
4fic	0UL	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.442
5dp2	NAP	CurF	/	0.442
1uy8	PU5	Heat shock protein HSP 90-alpha	/	0.441
1uyf	PU1	Heat shock protein HSP 90-alpha	/	0.441
2bn4	NAP	NADPH--cytochrome P450 reductase	/	0.441
3hz5	Z64	Heat shock protein HSP 90-alpha	/	0.441
3vs6	VSH	Tyrosine-protein kinase HCK	2.7.10.2	0.441
4cax	646	Glycylpeptide N-tetradecanoyltransferase	2.3.1.97	0.441
1aiq	CB3	Thymidylate synthase	/	0.440
2bak	AQZ	Mitogen-activated protein kinase 14	/	0.440
2bu9	HFV	Isopenicillin N synthase	1.21.3.1	0.440
2j9l	ATP	H(+)/Cl(-) exchange transporter 5	/	0.440
2ou2	ACO	Histone acetyltransferase KAT5	/	0.440
2xa4	AZ5	Tyrosine-protein kinase JAK2	/	0.440
3cqe	P91	Wee1-like protein kinase	2.7.10.2	0.440
4a9y	AQZ	Mitogen-activated protein kinase 14	/	0.440
4bby	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.440
4e2b	FMN	Dehydrogenase	/	0.440
4gh6	LUO	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.440