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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.587
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.566
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.526
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
5e8ySTUTGF-beta receptor type-22.7.11.300.515
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.512
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
4aqc88ATyrosine-protein kinase JAK2/0.511
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.510
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.507
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.506
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
4otiMI1Serine/threonine-protein kinase N1/0.505
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
3ncz3NCRho-associated protein kinase 12.7.11.10.501
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.495
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.493
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.491
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.490
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.488
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4e6d0NUTyrosine-protein kinase JAK2/0.484
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4i5cC5ITyrosine-protein kinase JAK1/0.480
2y9qANPMitogen-activated protein kinase 12.7.11.240.479
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
4y93746Tyrosine-protein kinase/0.478
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
4fv6E57Mitogen-activated protein kinase 12.7.11.240.476
4nifANPMitogen-activated protein kinase 12.7.11.240.476
1fm4DXCMajor pollen allergen Bet v 1-L/0.475
2pvmP29Casein kinase II subunit alpha2.7.11.10.474
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.474
3i60E86Mitogen-activated protein kinase 12.7.11.240.472
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2pvnP63Casein kinase II subunit alpha2.7.11.10.470
1m2pHNACasein kinase II subunit alpha2.7.11.10.469
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
3m0wP77Protein S100-A4/0.469
4h3qANPMitogen-activated protein kinase 12.7.11.240.469
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.469
4btjADPTau-tubulin kinase 12.7.11.10.467
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.466
2f2uM77Rho-associated protein kinase 22.7.11.10.466
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3lpbNVBTyrosine-protein kinase JAK2/0.465
4q73FADBifunctional protein PutA/0.465
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3nieANPMitogen-activated protein kinase/0.464
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.464
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
3juhANPCasein kinase II subunit alpha2.7.11.10.463
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.463
5e92ANPTGF-beta receptor type-22.7.11.300.463
1gqtACPRibokinase/0.462
2y4gTIRTamL/0.462
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.462
4hge15VTyrosine-protein kinase JAK2/0.462
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.459
4ivb1J5Tyrosine-protein kinase JAK1/0.459
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.458
2zjwREFCasein kinase II subunit alpha2.7.11.10.458
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4jx1CAHCamphor 5-monooxygenase1.14.15.10.458
4qnyANPMitogen activated protein kinase, putative/0.458
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3oqkS52Renin3.4.23.150.457
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
1y91CT9Cyclin-dependent kinase 22.7.11.220.456
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.455
4fmqANPMitogen-activated protein kinase 12.7.11.240.455
3rvg17PTyrosine-protein kinase JAK2/0.454
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
3mlaJJZProbable nicotinate-nucleotide adenylyltransferase/0.453
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
2po7CHDFerrochelatase, mitochondrial4.99.1.10.452
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
5cnoANPEpidermal growth factor receptor2.7.10.10.452
4a84DXCMajor pollen allergen Bet v 1-A/0.451
4anmWULCasein kinase II subunit alpha2.7.11.10.451
2gciMRRProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.450
3eldSFGMethyltransferase/0.450
4axdANPInositol-pentakisphosphate 2-kinase2.7.1.1580.450
4ck2NVUIntegrase/0.450
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.450
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2xa4AZ5Tyrosine-protein kinase JAK2/0.449
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.449
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4j95ACPFibroblast growth factor receptor 2/0.449
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
4o0wADNAurora kinase A2.7.11.10.449
3zh8C58Protein kinase C iota type2.7.11.130.448
4ipw1G7Mycocyclosin synthase1.14.21.90.448
2fznFADBifunctional protein PutA1.5.5.20.447
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.447
3d7kD7KBenzaldehyde lyase/0.447
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2b53D23Cyclin-dependent kinase 22.7.11.220.446
3be9P04Casein kinase II subunit alpha2.7.11.10.446
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.445
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3enkUPGUDP-glucose 4-epimerase/0.445
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3zxsFADDeoxyribodipyrimidine photolyase-related protein/0.445
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.445
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4hvi19STyrosine-protein kinase JAK32.7.10.20.444
4n6hEJ4Delta-type opioid receptor/0.444
4q72FADBifunctional protein PutA/0.444
2dvlFADAcyl-CoA dehydrogenase/0.443
2ft9CHDFatty acid-binding protein 2, liver/0.443
2xs0ANPMitogen-activated protein kinase 82.7.11.240.443
4f081RSTyrosine-protein kinase JAK2/0.443
4fkv61KCyclin-dependent kinase 22.7.11.220.443
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.442
2xrwANPMitogen-activated protein kinase 82.7.11.240.442
3cisATPUniversal stress protein Rv2623/0.442
4ji91M3Tyrosine-protein kinase JAK2/0.442
3pqbVGPPutative oxidoreductase/0.441
3u9eCOALmo1369 protein/0.441
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2dftADPShikimate kinase2.7.1.710.440
2ijmADPFocal adhesion kinase 12.7.10.20.440
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xtnGTPGTPase IMAP family member 2/0.440
3h86AP5Adenylate kinase/0.440
3imgBZ2Pantothenate synthetase6.3.2.10.440
4o59NADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.440