sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gj3 | FAD | Nitrogen fixation regulatory protein | 2.7.13.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2gj3 | FAD | Nitrogen fixation regulatory protein | 2.7.13.3 | 1.000 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.500 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.489 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.485 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.482 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.482 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.481 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.479 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.479 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.476 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.475 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.473 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.473 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.472 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.471 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.471 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.469 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.469 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.468 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.467 | |
| 2jkk | BI9 | Focal adhesion kinase 1 | 2.7.10.2 | 0.466 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.466 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.466 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.465 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.465 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.465 | |
| 3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.465 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.465 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 1zdw | FLV | Prenyltransferase | / | 0.464 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.464 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.464 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.463 | |
| 3ue6 | FMN | Aureochrome1 | / | 0.463 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.462 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.462 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.462 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.461 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.460 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.460 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.460 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.459 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.459 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.459 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.459 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.459 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.458 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.458 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.458 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.458 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.458 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.457 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.457 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 2pvj | P44 | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.456 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.455 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.455 | |
| 1r2j | FAD | FkbI | / | 0.455 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.455 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.455 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.455 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.455 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.454 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.454 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.454 | |
| 2owu | SAH | Diphthine synthase | / | 0.454 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.454 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.454 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 4nyw | 2O3 | CREB-binding protein | / | 0.454 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.454 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.453 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.453 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.453 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.453 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.453 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 2dxx | SAH | Diphthine synthase | / | 0.452 | |
| 2w1h | L0F | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 2xvw | 9NR | Serum albumin | / | 0.452 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 3egv | SAH | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.452 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.452 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.452 | |
| 1eio | GCH | Gastrotropin | / | 0.451 | |
| 1lqu | NDP | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.451 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.451 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.451 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.451 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.451 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.451 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.451 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.451 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.450 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.450 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.450 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.450 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.450 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.449 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.449 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.449 | |
| 2e07 | SAH | Diphthine synthase | / | 0.449 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.449 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.449 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.449 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.449 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.449 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1um0 | FMN | Chorismate synthase | / | 0.448 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.448 | |
| 2e08 | SAH | Diphthine synthase | / | 0.448 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.448 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.448 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.448 | |
| 3q92 | XNB | Ketohexokinase | / | 0.448 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.448 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.448 | |
| 5cds | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 5djt | FMN | NPH1-2 | / | 0.448 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.448 | |
| 5ii2 | LU2 | Protein polybromo-1 | / | 0.448 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.447 | |
| 2o12 | FMN | Chorismate synthase | / | 0.447 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.447 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.447 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.447 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.446 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.446 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.446 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2mwg | FMN | Blue-light photoreceptor | / | 0.446 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.446 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3b9l | AZZ | Serum albumin | / | 0.446 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 3d7t | STU | Tyrosine-protein kinase CSK | / | 0.446 | |
| 3gob | HXX | DdmC | / | 0.446 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.446 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.446 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.446 | |
| 1efa | NPF | Lactose operon repressor | / | 0.445 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.445 | |
| 1j91 | TBS | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.445 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.445 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.445 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.445 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.445 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.445 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.445 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.445 | |
| 1e2j | THM | Thymidine kinase | / | 0.444 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.444 | |
| 1gqt | ACP | Ribokinase | / | 0.444 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.444 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.444 | |
| 1xpq | FAD | Polyamine oxidase FMS1 | / | 0.444 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2mm3 | CHO | Gastrotropin | / | 0.444 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.444 | |
| 3p9t | TCL | Repressor | / | 0.444 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.444 | |
| 4aql | TXC | Guanine deaminase | 3.5.4.3 | 0.444 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.443 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.443 | |
| 1pxm | CK5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.443 | |
| 2eeq | SAH | Diphthine synthase | / | 0.443 | |
| 2emu | SAH | Diphthine synthase | / | 0.443 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.443 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3rpv | 26Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.443 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.443 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 5a3b | APR | SIR2 family protein | / | 0.443 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.443 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1vce | SAH | Diphthine synthase | / | 0.442 | |
| 2egs | SAH | Diphthine synthase | / | 0.442 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.442 | |
| 2xvv | 9DN | Serum albumin | / | 0.442 | |
| 2z6r | SAH | Diphthine synthase | / | 0.442 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.442 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.442 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.442 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.442 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.442 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.442 | |
| 5dbv | COA | Aldehyde Dehydrogenase | / | 0.442 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.442 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.442 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.441 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.441 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3mla | JJZ | Probable nicotinate-nucleotide adenylyltransferase | / | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.441 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.441 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1r8c | UTP | CCA-adding enzyme | 2.7.7.72 | 0.440 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.440 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.440 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.440 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.440 | |
| 3cr3 | ADP | PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.440 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.440 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.440 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3qxp | X64 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.440 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.440 | |
| 4n1g | CEI | Obelin | / | 0.440 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.440 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.440 |