Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ght | SER_PRO_THR_PRO_SEP | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | 3.1.3.16 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ght | SER_PRO_THR_PRO_SEP | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | 3.1.3.16 | 1.000 | |
| 1fgx | U5P | Beta-1,4-galactosyltransferase 1 | / | 0.515 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.506 | |
| 3bm4 | ADV | ADP-sugar pyrophosphatase | 3.6.1.13 | 0.503 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.500 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.496 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.494 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.493 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.492 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.490 | |
| 3qgz | ADN | Histidine triad nucleotide-binding protein 1 | 3 | 0.490 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.488 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.487 | |
| 3png | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.486 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1hv9 | UD1 | Bifunctional protein GlmU | / | 0.481 | |
| 2qjp | ANJ | Cytochrome b | / | 0.479 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.479 | |
| 5bp7 | SAH | SAM-dependent methyltransferase | / | 0.479 | |
| 3nlo | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.478 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.477 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.477 | |
| 5bn4 | ANP | V-type ATP synthase alpha chain | / | 0.477 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2mjp | ANP | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.473 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.472 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.472 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.472 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.471 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.471 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.471 | |
| 3of1 | CMP | cAMP-dependent protein kinase regulatory subunit | / | 0.470 | |
| 3rqm | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.470 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 4eux | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.470 | |
| 1l8t | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.469 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2dsc | APR | ADP-sugar pyrophosphatase | 3.6.1.13 | 0.469 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.469 | |
| 2xk6 | EQH | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.469 | |
| 3nly | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.469 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.469 | |
| 4bz7 | B3N | Histone deacetylase | / | 0.469 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.468 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.468 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.468 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.468 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.468 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.468 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.467 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.467 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.467 | |
| 4bfd | 8T3 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.467 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.466 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.466 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1om5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.465 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.465 | |
| 1h83 | FAD | Polyamine oxidase | 1.5.3.14 | 0.464 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.464 | |
| 2qhx | FE1 | Pteridine reductase 1 | 1.5.1.33 | 0.464 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.464 | |
| 4ys0 | ADP | Protein translocase subunit SecA | / | 0.464 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.463 | |
| 3e6t | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.463 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.463 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.463 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.463 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.463 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.462 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.462 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.462 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.461 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.461 | |
| 3nlz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.461 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.461 | |
| 4au7 | SAH | Histone-lysine N-methyltransferase KMT5C | 2.1.1.43 | 0.461 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.460 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.460 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.459 | |
| 2isc | 223 | Purine nucleoside phosphorylase, putative | / | 0.459 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.459 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.459 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.458 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.458 | |
| 3n0z | 3AT | Adenylate cyclase 2 | / | 0.458 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.457 | |
| 3fow | IMH | Purine nucleoside phosphorylase | / | 0.457 | |
| 3jwt | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.457 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.457 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1dtn | APG | Mandelate racemase | / | 0.456 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.456 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.456 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.456 | |
| 4iix | 1EG | Microcin C7 self-immunity protein MccF | / | 0.456 | |
| 4jsg | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 1ia9 | ANP | Transient receptor potential cation channel subfamily M member 7 | 2.7.11.1 | 0.455 | |
| 1nbh | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.455 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.455 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.455 | |
| 2oby | NAP | Quinone oxidoreductase PIG3 | 1 | 0.455 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.455 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.455 | |
| 3uq9 | TBN | Putative adenosine kinase | / | 0.455 | |
| 3zrr | PXG | Serine-pyruvate aminotransferase (AgxT) | / | 0.455 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.455 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.455 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.455 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.454 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.454 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.454 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.454 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.454 | |
| 1av5 | AP2 | Histidine triad nucleotide-binding protein 1 | 3 | 0.453 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.453 | |
| 2xvm | SAH | Tellurite methyltransferase | 2.1.1.265 | 0.453 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.453 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.453 | |
| 3tpt | ADP | Serine/threonine-protein kinase toxin HipA | / | 0.453 | |
| 3ufo | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 3uft | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.453 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.453 | |
| 4x81 | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.453 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.452 | |
| 2ejz | SAH | Diphthine synthase | / | 0.452 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.452 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.452 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.452 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.451 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.451 | |
| 2q5q | KPV | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.451 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.451 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.451 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.451 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.451 | |
| 1fr8 | GDU | Beta-1,4-galactosyltransferase 1 | / | 0.450 | |
| 1hi0 | GTP | RNA-directed RNA polymerase | 2.7.7.48 | 0.450 | |
| 1qv1 | CZH | Obelin | / | 0.450 | |
| 1rzy | 5AS | Histidine triad nucleotide-binding protein 1 | 3 | 0.450 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.450 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.450 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.450 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 3e7g | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.450 | |
| 3n5v | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 3nlk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.450 | |
| 4a1o | AMZ | Bifunctional purine biosynthesis protein PurH | 2.1.2.3 | 0.450 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.450 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.450 | |
| 5je3 | SAH | Methyl transferase | / | 0.450 | |
| 2cdc | NAP | Glucose 1-dehydrogenase | / | 0.449 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.449 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 3b3m | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.449 | |
| 3pnf | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 3rqj | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4cx5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.449 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.449 | |
| 4zs4 | ATP | Myosin heavy chain kinase A | 2.7.11.7 | 0.449 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.448 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 1tw2 | ERT | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.448 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 2xnn | 430 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.448 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.448 | |
| 3tm0 | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.448 | |
| 3vf2 | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.448 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.448 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4y9x | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.448 | |
| 1k8z | IAG | Tryptophan synthase alpha chain | / | 0.447 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.447 | |
| 1krv | 147 | Galactoside O-acetyltransferase | 2.3.1.18 | 0.447 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2q0g | UPU | Poly(A) polymerase, putative | / | 0.447 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.447 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.447 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.447 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3ar6 | 12D | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 3hgg | CHD | CmeR | / | 0.447 | |
| 3n63 | XFN | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 3nnz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 3nw2 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.447 | |
| 3qly | 55V | Uncharacterized protein | / | 0.447 | |
| 3rql | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 3ufw | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.447 | |
| 5agl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.446 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.446 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.446 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.446 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.446 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4j6i | 1JV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.445 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.445 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.445 | |
| 3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.445 | |
| 3ex8 | AIF | Riboflavin biosynthesis protein RibD | 1.1.1.193 | 0.445 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.445 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3kpf | FAD | Polyamine oxidase | 1.5.3.14 | 0.445 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.445 | |
| 3n60 | XFN | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3n66 | XFN | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3rqk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3ufr | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.445 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.445 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.445 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.444 | |
| 1k2u | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 1syn | F89 | Thymidylate synthase | / | 0.444 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.444 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.444 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 3fqj | GDP | Decapping and exoribonuclease protein | 3.1.13 | 0.444 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1e2l | TMC | Thymidine kinase | / | 0.443 | |
| 1kux | CA3 | Serotonin N-acetyltransferase | / | 0.443 | |
| 1vaf | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.443 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.443 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.443 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2zx8 | ZX8 | Alpha-L-fucosidase, putative | / | 0.443 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 3jwu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.443 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.443 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.443 | |
| 4y6g | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
| 5iqb | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1up6 | NAD | 6-phospho-beta-glucosidase BglT | 3.2.1.86 | 0.442 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.442 | |
| 2g86 | UMP | Thymidylate synthase | / | 0.442 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 2zx5 | ZX5 | Alpha-L-fucosidase, putative | / | 0.442 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.442 | |
| 3oxk | 5GP | Histidine triad nucleotide-binding protein | 3 | 0.442 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.442 | |
| 4cqn | ILA | Leucine--tRNA ligase | / | 0.442 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4jsf | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.441 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.441 | |
| 2c3u | 2TP | Pyruvate synthase | / | 0.441 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.441 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 2q0f | U5P | Poly(A) polymerase, putative | / | 0.441 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.441 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.441 | |
| 3inr | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 3lla | ACP | Myosin heavy chain kinase A | 2.7.11.7 | 0.441 | |
| 3pne | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3sr5 | Q12 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.441 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.441 | |
| 4lv8 | ADP | Rhoptry protein 5 C | / | 0.441 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1djq | FMN | Trimethylamine dehydrogenase | 1.5.8.2 | 0.440 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.440 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.440 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2i8c | ADP | D-alanine--D-alanine ligase | / | 0.440 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 3eek | 53S | Uncharacterized protein | / | 0.440 | |
| 3fpb | ATP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.440 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.440 | |
| 4h6p | FMN | Chromate reductase | / | 0.440 |