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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ghmLICMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ghmLICMitogen-activated protein kinase 14/1.000
4f9wLM4Mitogen-activated protein kinase 14/0.549
3mpaSB2Mitogen-activated protein kinase 14/0.519
3gc9B45Mitogen-activated protein kinase 112.7.11.240.515
1ywrLI9Mitogen-activated protein kinase 14/0.505
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.500
3ttiKBIMitogen-activated protein kinase 102.7.11.240.493
1pmn984Mitogen-activated protein kinase 102.7.11.240.489
3flsFLSMitogen-activated protein kinase 14/0.489
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.488
1ouk084Mitogen-activated protein kinase 14/0.484
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.484
3t8oATPRhodopsin kinase/0.480
2ittAEEEpidermal growth factor receptor2.7.10.10.479
1tvoFRZMitogen-activated protein kinase 12.7.11.240.477
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.474
1yw2PGJMitogen-activated protein kinase 14/0.473
3hllI45Mitogen-activated protein kinase 14/0.473
4dlj6RGMitogen-activated protein kinase 14/0.473
4kbk1QGCasein kinase I isoform delta2.7.11.10.473
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3igoANPCalmodulin-domain protein kinase 1, putative/0.472
4fuxE75Mitogen-activated protein kinase 12.7.11.240.471
1zyjBI5Mitogen-activated protein kinase 14/0.469
3c4xATPRhodopsin kinase/0.469
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.468
4qo9627Serine/threonine-protein kinase 242.7.11.10.468
2vwu7X1Ephrin type-B receptor 42.7.10.10.467
2excJNKMitogen-activated protein kinase 102.7.11.240.465
4j95ACPFibroblast growth factor receptor 2/0.465
3erkSB4Mitogen-activated protein kinase 12.7.11.240.464
2j0lANPFocal adhesion kinase 12.7.10.20.463
4eym0RXMitogen-activated protein kinase 132.7.11.240.463
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.461
2xvdAS6Ephrin type-B receptor 42.7.10.10.461
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.461
4eh60ONMitogen-activated protein kinase 14/0.461
4nks2M2Fibroblast growth factor receptor 1/0.461
3fmn530Mitogen-activated protein kinase 14/0.460
3roc29AMitogen-activated protein kinase 14/0.460
4gyiADPUncharacterized protein/0.459
4hyu1BKMitogen-activated protein kinase 82.7.11.240.459
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
3uyt0CKCasein kinase I isoform delta2.7.11.10.458
2qo9ANPEphrin type-A receptor 32.7.10.10.457
4g2fC07Ephrin type-A receptor 32.7.10.10.457
2bujSTUSerine/threonine-protein kinase 16/0.456
4gk2L66Ephrin type-A receptor 32.7.10.10.456
1sn5T3Transthyretin/0.455
2vww7X2Ephrin type-B receptor 42.7.10.10.455
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.455
4ic7ANPMitogen-activated protein kinase 72.7.11.240.455
4izy1J2Mitogen-activated protein kinase 82.7.11.240.455
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.455
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.454
4eh50OMMitogen-activated protein kinase 14/0.454
1finATPCyclin-dependent kinase 22.7.11.220.453
2henADPEphrin type-B receptor 22.7.10.10.453
3hp552PMitogen-activated protein kinase 14/0.453
3kf7L9GMitogen-activated protein kinase 14/0.453
4anqVGHALK tyrosine kinase receptor2.7.10.10.453
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1ictT44Transthyretin/0.452
2py3ACPFibroblast growth factor receptor 2/0.452
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.452
3w2sW2REpidermal growth factor receptor2.7.10.10.452
4c4f7CEDual specificity protein kinase TTK2.7.12.10.452
2etm7PYFocal adhesion kinase 12.7.10.20.451
2pwlACPFibroblast growth factor receptor 2/0.451
3s4qNK0Mitogen-activated protein kinase 14/0.451
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.451
4e730NRMitogen-activated protein kinase 82.7.11.240.451
1bygSTUTyrosine-protein kinase CSK/0.450
3a7hATPSerine/threonine-protein kinase 242.7.11.10.450
3w33W19Epidermal growth factor receptor2.7.10.10.450
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.450
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.450
4f640S8Fibroblast growth factor receptor 1/0.450
4qmlANPSerine/threonine-protein kinase 242.7.11.10.449
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.448
2p33J07Mitogen-activated protein kinase 102.7.11.240.448
3fc152PMitogen-activated protein kinase 14/0.448
3mdvCL6Cholesterol 24-hydroxylase/0.448
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.448
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.447
2vwz7X6Ephrin type-B receptor 42.7.10.10.447
5ap7SVEDual specificity protein kinase TTK2.7.12.10.447
2ev9NAPShikimate dehydrogenase (NADP(+))/0.446
2vx07X7Ephrin type-B receptor 42.7.10.10.446
3ttjJBIMitogen-activated protein kinase 102.7.11.240.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4gk3L87Ephrin type-A receptor 32.7.10.10.446
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4jrnANPRhoptry kinase family protein/0.446
4loqSB4Mitogen-activated protein kinase 14/0.446
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.445
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.445
4ansVGHALK tyrosine kinase receptor2.7.10.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4l9i8PRRhodopsin kinase/0.445
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.445
5auwQUEDeath-associated protein kinase 12.7.11.10.445
2hw2RFPRifampin ADP-ribosyl transferase/0.444
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.444
3vjoANPEpidermal growth factor receptor2.7.10.10.444
4wkqIREEpidermal growth factor receptor2.7.10.10.444
1eupASD6-deoxyerythronolide B hydroxylase/0.443
2fgiPD1Fibroblast growth factor receptor 1/0.443
2izrBRKCasein kinase I isoform gamma-32.7.11.10.443
2vwy7X5Ephrin type-B receptor 42.7.10.10.443
2yfxVGHALK tyrosine kinase receptor2.7.10.10.443
3fmkFMKMitogen-activated protein kinase 14/0.443
3vt8YI3Vitamin D3 receptor/0.443
3zsi52PMitogen-activated protein kinase 14/0.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.443
1m17AQ4Epidermal growth factor receptor2.7.10.10.442
3uibSB2Putative mitogen-activated protein kinase/0.442
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.442
1ie4T44Transthyretin/0.441
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2vd5BI8Myotonin-protein kinase2.7.11.10.441
3fln3FNMitogen-activated protein kinase 14/0.441
4bcmT7ZCyclin-dependent kinase 22.7.11.220.441
4ez50RSCyclin-dependent kinase 62.7.11.220.441
4k33ACPFibroblast growth factor receptor 32.7.10.10.441
4lopSB4Mitogen-activated protein kinase 14/0.441
1jioDEB6-deoxyerythronolide B hydroxylase/0.440
3dt1P40Mitogen-activated protein kinase 14/0.440
3zc3NAPFerredoxin--NADP reductase1.18.1.20.440
4btkDTQTau-tubulin kinase 12.7.11.10.440
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440