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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gg8U15Methionine aminopeptidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gg8U15Methionine aminopeptidase/1.000
2q94A04Methionine aminopeptidase/0.668
2evcFC3Methionine aminopeptidase/0.633
2evmFC2Methionine aminopeptidase/0.629
2gg3U13Methionine aminopeptidase/0.627
2ggbU17Methionine aminopeptidase/0.618
3pkeY10Methionine aminopeptidase 2/0.598
2q93B21Methionine aminopeptidase/0.584
2gg0U11Methionine aminopeptidase/0.583
2gg9U16Methionine aminopeptidase/0.582
3iu7FCDMethionine aminopeptidase 2/0.578
3iu8T03Methionine aminopeptidase 2/0.573
2q92B23Methionine aminopeptidase/0.570
4ikuSHXMethionine aminopeptidase 1/0.566
3pkaY02Methionine aminopeptidase 2/0.564
3pkdY10Methionine aminopeptidase 2/0.562
2p98YE7Methionine aminopeptidase/0.558
4iksTFDMethionine aminopeptidase 1/0.557
3pkbY16Methionine aminopeptidase 2/0.555
3d27W29Methionine aminopeptidase/0.553
4iktTFVMethionine aminopeptidase 1/0.553
2q96A18Methionine aminopeptidase/0.552
2g6pHM2Methionine aminopeptidase 1/0.546
4fllYZ6Methionine aminopeptidase 1/0.536
4hxx1AYMethionine aminopeptidase 1/0.531
4fliY16Methionine aminopeptidase 1/0.526
4ikrPVPMethionine aminopeptidase 1/0.518
1xnzFCDMethionine aminopeptidase/0.511
2p99YE6Methionine aminopeptidase/0.511
2nq7HM5Methionine aminopeptidase 1/0.509
1c23MPHMethionine aminopeptidase/0.505
4flkY10Methionine aminopeptidase 1/0.499
1qzyTDEMethionine aminopeptidase 2/0.492
2gg2U12Methionine aminopeptidase/0.491
3iu9T07Methionine aminopeptidase 2/0.486
2gywOBIAcetylcholinesterase3.1.1.70.481
2oazI96Methionine aminopeptidase 2/0.473
2jf0HBPAcetylcholinesterase3.1.1.70.470
2xupTZ5Acetylcholinesterase3.1.1.70.467
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.467
1r5gAO1Methionine aminopeptidase 2/0.465
2xuqTZ4Acetylcholinesterase3.1.1.70.460
1odcA8BAcetylcholinesterase3.1.1.70.459
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
4fljY08Methionine aminopeptidase 1/0.459
1q84TZ4Acetylcholinesterase3.1.1.70.458
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.458
1tllFMNNitric oxide synthase, brain1.14.13.390.456
1h22E10Acetylcholinesterase3.1.1.70.451
4ey7E20Acetylcholinesterase3.1.1.70.450
2j3qTFLAcetylcholinesterase3.1.1.70.448
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.448
1vkgCRIHistone deacetylase 83.5.1.980.447
2xuiTZ5Acetylcholinesterase3.1.1.70.447
2wzySQXSoluble acetylcholine receptor/0.446
3pkcY08Methionine aminopeptidase 2/0.446
4arbC57Acetylcholinesterase3.1.1.70.446
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.445
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.445
3pdqKC6Lysine-specific demethylase 4A1.14.110.445
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
1w6rGNTAcetylcholinesterase3.1.1.70.443
2aouCQAHistamine N-methyltransferase2.1.1.80.443
2cekN8TAcetylcholinesterase3.1.1.70.443
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.443
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.443
2ea2F77Methionine aminopeptidase 2/0.442
2ga2A19Methionine aminopeptidase 2/0.442
2ha6SCKAcetylcholinesterase3.1.1.70.442
1amoFMNNADPH--cytochrome P450 reductase/0.440
1r5hAO2Methionine aminopeptidase 2/0.440
2xugTZ4Acetylcholinesterase3.1.1.70.440