sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gg0 | U11 | Methionine aminopeptidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2gg0 | U11 | Methionine aminopeptidase | / | 1.000 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.662 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.654 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.647 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.625 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.615 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.612 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.611 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.611 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.605 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.604 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.604 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.604 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.602 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.602 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.598 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.596 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.584 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.582 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.577 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.575 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.565 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.562 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.546 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.539 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.538 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.536 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.533 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.531 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.531 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.526 | |
| 4ikr | PVP | Methionine aminopeptidase 1 | / | 0.518 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.517 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.514 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.511 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.510 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.504 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.501 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.498 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.495 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.490 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.490 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.489 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.489 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.487 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.486 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.486 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.483 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.480 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.478 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.477 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.476 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.476 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.475 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.475 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.475 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.474 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.474 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.474 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.474 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.473 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.473 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.472 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.472 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.472 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.468 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.468 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.468 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.467 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.466 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.464 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.464 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.464 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.464 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.464 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.464 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.464 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.463 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.463 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.462 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.461 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.461 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.461 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.461 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.461 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.460 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.460 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.460 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.460 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.459 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.459 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.459 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.459 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.458 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.458 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.457 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.457 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.456 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.456 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.455 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.455 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.455 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.454 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.454 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.454 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.454 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.453 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.453 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.452 | |
| 4lut | DCS | Alanine racemase | / | 0.452 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.451 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.451 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.451 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.451 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.450 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.450 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.450 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.450 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.450 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.449 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.449 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.449 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.449 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.449 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.448 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.448 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.448 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.448 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.447 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.446 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.446 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.446 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.446 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.446 | |
| 4qg1 | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.446 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.446 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.446 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.445 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.445 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4e2y | JHZ | Methyltransferase | / | 0.445 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.445 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.444 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.444 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.443 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.443 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.443 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.443 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.442 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.442 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2ejz | SAH | Diphthine synthase | / | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.441 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.441 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.441 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4l7h | 1W1 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.440 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 |