sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gcp | GSP | Rho-related GTP-binding protein RhoC |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 1.000 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.652 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.644 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.634 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.611 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.603 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.602 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.592 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.591 | |
| 1s1c | GNP | Transforming protein RhoA | / | 0.589 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.585 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.583 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.566 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.562 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.557 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.555 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.554 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.554 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.544 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.543 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.541 | |
| 1gwn | GTP | Rho-related GTP-binding protein RhoE | / | 0.540 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.539 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.538 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.537 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.536 | |
| 4gzm | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.534 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.532 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.532 | |
| 1z2c | GNP | Rho-related GTP-binding protein RhoC | / | 0.526 | |
| 4mit | GTP | Rho-related protein racC | / | 0.526 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.522 | |
| 4nyj | GNP | GTPase HRas | / | 0.522 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.521 | |
| 2zet | GTP | Ras-related protein Rab-27B | / | 0.517 | |
| 4dvg | GSP | Rho family GTPase | / | 0.516 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.511 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.510 | |
| 3lbn | GNP | GTPase HRas | / | 0.510 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.508 | |
| 3law | GNP | Ras-related protein Rab-7a | / | 0.508 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.508 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.507 | |
| 3tnf | GNP | Ras-related protein Rab-8A | / | 0.507 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.507 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.506 | |
| 2c5l | GTP | GTPase HRas | / | 0.504 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.503 | |
| 3oiu | GNP | GTPase HRas | / | 0.503 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.500 | |
| 4g0n | GNP | GTPase HRas | / | 0.500 | |
| 4nyi | GNP | GTPase HRas | / | 0.499 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.498 | |
| 3v4f | GNP | GTPase HRas | / | 0.497 | |
| 4dsn | GCP | GTPase KRas | / | 0.497 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.497 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.496 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.496 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.493 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.492 | |
| 4k81 | GTP | GTPase HRas | / | 0.492 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.492 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.490 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.490 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.489 | |
| 2rge | GNP | GTPase HRas | / | 0.488 | |
| 3tgp | GNP | GTPase HRas | / | 0.488 | |
| 4cym | GCP | Ras-related protein Rab-32 | / | 0.487 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.485 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.484 | |
| 3lbh | GNP | GTPase HRas | / | 0.483 | |
| 4dso | GSP | GTPase KRas | / | 0.482 | |
| 2rgc | GNP | GTPase HRas | / | 0.481 | |
| 3ddc | GNP | GTPase HRas | / | 0.481 | |
| 3i3s | GNP | GTPase HRas | / | 0.479 | |
| 4dlt | GNP | GTPase HRas | / | 0.479 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.478 | |
| 3oiv | GNP | GTPase HRas | / | 0.477 | |
| 3rs7 | GNP | GTPase HRas | / | 0.476 | |
| 3rs4 | GNP | GTPase HRas | / | 0.475 | |
| 3tkl | GTP | Ras-related protein Rab-1A | / | 0.474 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.474 | |
| 3k8y | GNP | GTPase HRas | / | 0.473 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.472 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.470 | |
| 2cls | GTP | Rho-related GTP-binding protein Rho6 | / | 0.469 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.468 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.466 | |
| 3lbi | GNP | GTPase HRas | / | 0.465 | |
| 2rgb | GNP | GTPase HRas | / | 0.463 | |
| 5b2z | GNP | GTPase HRas | / | 0.463 | |
| 3bc1 | GNP | Ras-related protein Rab-27A | / | 0.462 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.462 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.460 | |
| 3l8y | GNP | GTPase HRas | / | 0.460 | |
| 4dlx | GNP | GTPase HRas | / | 0.458 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.457 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.456 | |
| 3kud | GDP | GTPase HRas | / | 0.456 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.455 | |
| 3oiw | GNP | GTPase HRas | / | 0.455 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.455 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.454 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.454 | |
| 4dlw | GNP | GTPase HRas | / | 0.453 | |
| 4oi2 | ADP | Protein clpf-1 | / | 0.453 | |
| 2ic5 | GNP | Ras-related C3 botulinum toxin substrate 3 | / | 0.452 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.451 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.451 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.451 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.450 | |
| 1lfd | GNP | GTPase HRas | / | 0.449 | |
| 2rgg | GNP | GTPase HRas | / | 0.449 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.447 | |
| 4dlz | GNP | GTPase HRas | / | 0.447 | |
| 4luc | GDP | GTPase KRas | / | 0.446 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.442 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.442 |