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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2g89UMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2g89UMPThymidylate synthase/1.000
2g8aUMPThymidylate synthase/0.755
2g86UMPThymidylate synthase/0.643
1njbUMPThymidylate synthase/0.595
1njeDCMThymidylate synthase/0.588
1tsyUMPThymidylate synthase/0.562
1jmfUMPThymidylate synthase/0.558
1bp6UMPThymidylate synthase/0.552
1njdUMPThymidylate synthase/0.550
1jmiUMPThymidylate synthase/0.548
1tsvUMPThymidylate synthase/0.546
2tdmUMPThymidylate synthase/0.534
1jmgUMPThymidylate synthase/0.520
2g8dUMPThymidylate synthase/0.502
1bidUMPThymidylate synthase/0.501
1vzbUMPThymidylate synthase/0.501
1bpjUMPThymidylate synthase/0.500
1vzaUMPThymidylate synthase/0.500
1njcDCMThymidylate synthase/0.494
1lcbTMPThymidylate synthase/0.482
1tsxUMPThymidylate synthase/0.473
1jmhUMPThymidylate synthase/0.468
1bp0UMPThymidylate synthase/0.453
1aobDDUThymidylate synthase/0.450
1njaDCMThymidylate synthase/0.450
3bgxTMPThymidylate synthase/0.444
2vetUMPThymidylate synthase/0.443