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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2g86UMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2g86UMPThymidylate synthase/1.000
2g8aUMPThymidylate synthase/0.760
2g89UMPThymidylate synthase/0.667
1tsyUMPThymidylate synthase/0.660
2tdmUMPThymidylate synthase/0.644
1njdUMPThymidylate synthase/0.639
1tsxUMPThymidylate synthase/0.626
1bpjUMPThymidylate synthase/0.620
1njeDCMThymidylate synthase/0.604
1tsvUMPThymidylate synthase/0.599
1vzbUMPThymidylate synthase/0.599
1jmgUMPThymidylate synthase/0.585
1bp6UMPThymidylate synthase/0.577
1jmfUMPThymidylate synthase/0.568
1njbUMPThymidylate synthase/0.544
1jmiUMPThymidylate synthase/0.529
1bidUMPThymidylate synthase/0.522
1njcDCMThymidylate synthase/0.521
1jmhUMPThymidylate synthase/0.517
1vzaUMPThymidylate synthase/0.501
1lcbTMPThymidylate synthase/0.498
2g8dUMPThymidylate synthase/0.489
3bgxTMPThymidylate synthase/0.474
1aobDDUThymidylate synthase/0.449
2vetUMPThymidylate synthase/0.446
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.445
1njaDCMThymidylate synthase/0.443