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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2g25TDKPyruvate dehydrogenase E1 component1.2.4.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2g25TDKPyruvate dehydrogenase E1 component1.2.4.11.000
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.581
2qtcTDKPyruvate dehydrogenase E1 component1.2.4.10.509
2r5nTPPTransketolase 1/0.462
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.459
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.459
1ay0TPPTransketolase 12.2.1.10.448
1tkaN3TTransketolase 12.2.1.10.448
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.446
3h3t16HCollagen type IV alpha-3-binding protein/0.443