scPDB - Distribution of Binding site Similarity values of 2fzj entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2fzj	DH3	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	1.000
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.628
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.626
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.615
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.576
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.572
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.570
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.566
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.562
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.561
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.558
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.557
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.555
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.554
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.551
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.549
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.543
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.543
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.541
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.539
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.538
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.526
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.525
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.524
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.523
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.523
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.519
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.517
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.516
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.515
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.505
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.505
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.499
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.491
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.491
2zza	FOL	Dihydrofolate reductase	/	0.487
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.486
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.485
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.480
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.479
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.479
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.478
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.476
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.476
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.475
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.475
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.474
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.474
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.473
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.470
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.469
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.469
1nqu	RDL	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.468
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.467
1ry0	PG2	Aldo-keto reductase family 1 member C3	/	0.467
4g1n	NZT	Pyruvate kinase PKM	2.7.1.40	0.467
4jib	1L6	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.467
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.466
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.465
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.464
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.463
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.462
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.461
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.461
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.460
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.460
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
2ouu	35G	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.458
3d3p	20A	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.458
1q9m	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.457
1y2d	4DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.457
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.457
3jsx	CC2	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.456
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.456
3qly	55V	Uncharacterized protein	/	0.456
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.455
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.455
3o57	ZG2	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.455
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.454
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.454
3cse	N22	Uncharacterized protein	/	0.454
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.454
3t8x	T8X	T-cell surface glycoprotein CD1b	/	0.454
3uza	T4G	Adenosine receptor A2a	/	0.454
2f98	NGV	Aklanonic acid methyl ester cyclase AcmA	5.5.1.23	0.453
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.453
4qa0	SHH	Histone deacetylase 8	3.5.1.98	0.453
3ar4	TG1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	3.6.3.8	0.452
3qlx	QLR	Uncharacterized protein	/	0.452
1kyx	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.451
1ps9	MDE	2,4-dienoyl-CoA reductase	1.3.1.34	0.451
1rvv	INI	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.450
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.450
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.449
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.448
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.448
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.448
4muw	2F4	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.448
3ezp	B3N	Histone deacetylase 8	3.5.1.98	0.447
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.447
5d7q	4I5	NAD-dependent protein deacetylase sirtuin-2	3.5.1	0.447
3a1l	2CC	Cytochrome P450	/	0.446
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.446
3hxe	BD8	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.446
3itu	IBM	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.446
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.446
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.446
4h9t	HL4	Phosphotriesterase	/	0.446
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.445
3l6j	Z90	Alr2278 protein	/	0.445
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.445
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.444
2zb8	IMN	Prostaglandin reductase 2	1.3.1.48	0.444
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.444
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.444
3sl6	JN8	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.444
3v94	WYQ	Phosphodiesterase	/	0.444
4at3	LTI	BDNF/NT-3 growth factors receptor	2.7.10.1	0.444
4ddl	0JQ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.444
4fam	0SZ	Aldo-keto reductase family 1 member C3	/	0.444
3qlz	QLZ	Uncharacterized protein	/	0.443
4dbw	511	Aldo-keto reductase family 1 member C3	/	0.443
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.443
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.442
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.441
1xon	PIL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.441
3svq	JK4	Nitric oxide synthase, brain	1.14.13.39	0.441
4jvm	XDI	Estrogen sulfotransferase	2.8.2.4	0.441
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.440
2fb8	215	Serine/threonine-protein kinase B-raf	2.7.11.1	0.440
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.440
3bv7	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.440
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.440