scPDB - Distribution of Binding site Similarity values of 2fzh entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2fzh	DH1	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	1.000
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.675
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.598
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.591
3cse	N22	Uncharacterized protein	/	0.589
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.586
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.579
3qly	55V	Uncharacterized protein	/	0.579
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.578
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.575
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.569
3eel	53T	Uncharacterized protein	/	0.568
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.564
3eek	53S	Uncharacterized protein	/	0.558
3eej	53R	Uncharacterized protein	/	0.553
3qlx	QLR	Uncharacterized protein	/	0.553
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.553
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.551
3qlz	QLZ	Uncharacterized protein	/	0.551
4h98	14Q	Uncharacterized protein	/	0.549
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.547
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.544
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.543
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.540
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.539
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.536
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.535
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.534
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.533
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.532
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.531
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.530
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.530
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.529
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.529
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.529
3eem	53V	Uncharacterized protein	/	0.521
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.521
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.516
3ia4	MTX	Dihydrofolate reductase	/	0.512
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.510
2zza	FOL	Dihydrofolate reductase	/	0.508
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.507
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.501
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.498
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.494
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.492
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.491
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.491
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.491
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.489
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.487
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.486
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.485
2w3v	TOP	Dihydrofolate reductase	/	0.484
3jwm	5WB	Dihydrofolate reductase	/	0.483
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.482
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.481
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.481
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.480
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.479
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.478
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.478
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.477
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.477
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.476
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.475
3tq9	MTX	Dihydrofolate reductase	/	0.475
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.473
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.471
3dau	MTX	Dihydrofolate reductase	1.5.1.3	0.470
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.469
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.469
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.468
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.466
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.466
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.465
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.463
3dat	MTX	Dihydrofolate reductase	/	0.462
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.461
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.461
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.461
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.460
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.459
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
2w3w	VG9	Dihydrofolate reductase	/	0.458
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.457
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.456
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.455
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
3m08	RAR	Dihydrofolate reductase	1.5.1.3	0.455
1dyr	TOP	Dihydrofolate reductase	1.5.1.3	0.454
3srw	Q27	Dihydrofolate reductase	1.5.1.3	0.454
4ele	31I	Dihydrofolate reductase	/	0.454
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.453
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.453
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.453
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.453
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.452
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.452
3jw5	TOP	Dihydrofolate reductase	/	0.452
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.452
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.452
3fl8	RAR	Dihydrofolate reductase	/	0.451
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.450
3sgy	06W	Dihydrofolate reductase	1.5.1.3	0.450
3vt7	VDX	Vitamin D3 receptor	/	0.450
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.449
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.447
2hcd	BIV	Vitamin D3 receptor A	/	0.447
3jwc	EKB	Dihydrofolate reductase	/	0.447
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.447
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
1qzf	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.446
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.446
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.446
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.443
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.443
1fm4	DXC	Major pollen allergen Bet v 1-L	/	0.442
3sa1	6DR	Dihydrofolate reductase	/	0.442
3jw3	TOP	Dihydrofolate reductase	/	0.441
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.440
3srs	M23	Dihydrofolate reductase	1.5.1.3	0.440