sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2fzb | TOL | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.718 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.638 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.572 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.567 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.559 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.558 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.547 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.517 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.507 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.506 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.506 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.506 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.505 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.505 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.502 | |
| 4phl | PIL | Phosphodiesterase | / | 0.496 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.494 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.489 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.488 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.488 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.487 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.486 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.486 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.484 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.482 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.482 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.482 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.481 | |
| 1lke | DOG | Bilin-binding protein | / | 0.480 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.480 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.480 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.480 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.478 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.475 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.474 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.474 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.474 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.473 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.473 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.473 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.472 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.472 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.472 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.472 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.472 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.471 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.470 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.469 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.469 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.468 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.468 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.468 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.468 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.467 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.467 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.466 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.466 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.466 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.466 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.464 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.464 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.464 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.463 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.463 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 2hzq | STR | Apolipoprotein D | / | 0.462 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.462 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.462 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.462 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.461 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.461 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.461 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.460 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.460 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.459 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.459 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.459 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.459 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.459 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.459 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.458 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.458 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.458 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2j7d | GI1 | Beta-glucosidase A | 3.2.1.21 | 0.458 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.458 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.458 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.458 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.457 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.457 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.457 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.457 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.456 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.456 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.456 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.455 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.455 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.455 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.455 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.454 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.453 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1rxj | BNI | Streptavidin | / | 0.452 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.451 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.451 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.451 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.451 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.451 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4mm4 | 8PR | Na(+):neurotransmitter symporter (Snf family) | / | 0.451 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.451 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.450 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3zhv | TDW | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.450 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4kxj | P34 | Nucleoprotein | / | 0.450 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.450 | |
| 1s36 | CEI | Obelin | / | 0.449 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.449 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.449 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.448 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.448 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.447 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.447 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.447 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3w5u | FAD | Ferredoxin | / | 0.447 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.447 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.446 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.446 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.446 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.446 | |
| 4yfy | 0FX | VioF | / | 0.446 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.446 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.445 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.445 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.444 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.444 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2xlt | NA0 | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.444 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.443 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.443 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4h2i | A12 | 5'-nucleotidase | 3.1.3.5 | 0.443 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.443 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.442 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.442 | |
| 1syn | F89 | Thymidylate synthase | / | 0.442 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.442 | |
| 2xeg | CI9 | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.442 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.442 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.442 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.442 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.442 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.441 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.441 | |
| 2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.441 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.441 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.441 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.441 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.441 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.440 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.440 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3dlg | GWE | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3gam | MXX | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.440 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.440 |