sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 1.000 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.642 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.632 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.620 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.614 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.612 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.604 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.602 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.601 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.599 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.597 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.595 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.592 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.592 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.591 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.590 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.582 | |
| 3ied | AN2 | HSP90 | / | 0.579 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.578 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.574 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.572 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.571 | |
| 2fyp | RDE | Endoplasmin | / | 0.571 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 2o1u | ANP | Endoplasmin | / | 0.569 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.568 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.567 | |
| 2exl | GDM | Endoplasmin | / | 0.566 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 1yt0 | ADP | Endoplasmin | / | 0.562 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.559 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.559 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.555 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.555 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.555 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.555 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.552 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.552 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 1u2o | NEC | Endoplasmin | / | 0.549 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.549 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.549 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.548 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.545 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.544 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.544 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.541 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.540 | |
| 2o1v | ADP | Endoplasmin | / | 0.540 | |
| 1u0z | RDC | Endoplasmin | / | 0.539 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 2esa | GDM | Endoplasmin | / | 0.537 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.536 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.535 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.535 | |
| 2hch | N5A | Endoplasmin | / | 0.534 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.534 | |
| 2gqp | PA7 | Endoplasmin | / | 0.532 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 1qy8 | RDI | Endoplasmin | / | 0.531 | |
| 2hg1 | N5O | Endoplasmin | / | 0.531 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.529 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.529 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.524 | |
| 2gfd | RDA | Endoplasmin | / | 0.523 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 1ysz | NEC | Endoplasmin | / | 0.516 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 1qy5 | NEC | Endoplasmin | / | 0.514 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.512 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.509 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.509 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.508 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.507 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.506 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.498 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.498 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.495 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.495 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 1u0y | PA7 | Endoplasmin | / | 0.492 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.491 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.491 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.489 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.486 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.486 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.485 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.485 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.484 | |
| 2xx5 | 13N | ATP-dependent molecular chaperone HSP82 | / | 0.484 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.483 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.480 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.479 | |
| 3u9e | COA | Lmo1369 protein | / | 0.479 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.477 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.475 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 3eof | FMN | Putative oxidase | / | 0.474 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 2bu2 | ATP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.473 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.472 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.470 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.469 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.469 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 1icu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.468 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.467 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.467 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.467 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.466 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.466 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.466 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.465 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.465 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.464 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.463 | |
| 1r2j | FAD | FkbI | / | 0.463 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.463 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.462 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.462 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.462 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.461 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.461 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.460 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.460 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.460 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.460 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.460 | |
| 1i5b | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.459 | |
| 1ol6 | ATP | Aurora kinase A | 2.7.11.1 | 0.459 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.459 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.459 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.458 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.458 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.458 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.458 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.457 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.457 | |
| 4fl2 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.457 | |
| 1jgt | APC | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.456 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.456 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2z7l | S91 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.455 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.455 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4en4 | ATP | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 4jvr | 1MT | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.455 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.454 | |
| 3eej | 53R | Uncharacterized protein | / | 0.454 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.454 | |
| 4e93 | GUI | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.454 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.454 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.454 | |
| 1nxk | STU | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.453 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.453 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.453 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.453 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4ig0 | 1FG | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.453 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.452 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.452 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.452 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.452 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.452 | |
| 4yhj | AN2 | G protein-coupled receptor kinase 4 | 2.7.11.16 | 0.452 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.451 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.451 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.451 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.451 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.451 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3gob | HXX | DdmC | / | 0.451 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4nh9 | 2LC | Endoplasmin | / | 0.451 | |
| 4ok1 | 198 | Androgen receptor | / | 0.451 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.451 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.451 | |
| 5cns | CDP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.451 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.450 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.450 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2yyu | C5P | Orotidine 5'-phosphate decarboxylase | / | 0.450 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.450 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.450 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.449 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 2y4g | TIR | TamL | / | 0.449 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.449 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.449 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.448 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.448 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.448 | |
| 2v1a | FMN | NPH1-1 | / | 0.448 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.448 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.448 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4bcn | T9N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.448 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.448 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1h7u | AGS | Mismatch repair endonuclease PMS2 | 3.1 | 0.447 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.447 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.447 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.447 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.447 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.447 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.447 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.447 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.447 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.446 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 1yin | CM3 | Estrogen receptor | / | 0.446 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.446 | |
| 2y3r | TIR | TamL | / | 0.446 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3pxv | FMN | Nitroreductase | / | 0.446 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.446 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.446 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.446 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.446 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.446 | |
| 1am4 | GNP | Cell division control protein 42 homolog | / | 0.445 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.445 | |
| 1kqb | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.445 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.445 | |
| 1ryw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.445 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.445 | |
| 4e03 | ADP | Plasmid partitioning protein ParF | / | 0.445 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.445 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.445 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 4z69 | DIF | Serum albumin | / | 0.445 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.445 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.444 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.444 | |
| 1ol5 | ADP | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 1sn5 | T3 | Transthyretin | / | 0.444 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.444 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2xzw | ATP | Nitrogen regulatory protein P-II | / | 0.444 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.444 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.444 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.444 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.444 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.444 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.444 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.444 | |
| 4jld | ADP | Adenylate kinase | / | 0.444 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.444 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.444 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.443 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.443 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2hkj | RDC | Type 2 DNA topoisomerase 6 subunit B | / | 0.443 | |
| 2o2u | 738 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2vwu | 7X1 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.443 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3q9w | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4a4z | ANP | Antiviral helicase SKI2 | 3.6.4.13 | 0.443 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.442 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.442 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.442 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4ac0 | MIY | Tetracycline repressor protein class B from transposon Tn10 | / | 0.442 | |
| 4iaz | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4mvf | STU | Calcium-dependent protein kinase 2 | 2.7.11.1 | 0.442 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.442 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.442 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.442 | |
| 1ei1 | ANP | DNA gyrase subunit B | / | 0.441 | |
| 1i44 | ACP | Insulin receptor | 2.7.10.1 | 0.441 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.441 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.441 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 2dbv | NDP | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.441 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 2xne | ASH | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.441 | |
| 3op5 | REB | Serine/threonine-protein kinase VRK1 | 2.7.11.1 | 0.441 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.441 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4bbe | 3O4 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.441 | |
| 4fsy | HK7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.441 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.441 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4xwt | U5P | Ribonuclease J | / | 0.441 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.440 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 1hk3 | T44 | Serum albumin | / | 0.440 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.440 | |
| 1mf0 | GDP | Adenylosuccinate synthetase isozyme 1 | / | 0.440 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.440 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2q8i | RDC | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | 2.7.11.2 | 0.440 | |
| 2qtv | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.440 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.440 | |
| 2y3r | TRK | TamL | / | 0.440 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.440 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.440 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.440 | |
| 3moh | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.440 | |
| 4fl1 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4fl3 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.440 | |
| 4oau | ADP | 2-5A-dependent ribonuclease | 3.1.26 | 0.440 | |
| 4u7w | NDP | MxaA | / | 0.440 |