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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fwzH71Heat shock protein HSP 90-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fwzH71Heat shock protein HSP 90-alpha/1.000
1uy9PU6Heat shock protein HSP 90-alpha/0.771
1uykPUXHeat shock protein HSP 90-alpha/0.740
1uy7PU4Heat shock protein HSP 90-alpha/0.736
2fwyH64Heat shock protein HSP 90-alpha/0.729
1uydPU8Heat shock protein HSP 90-alpha/0.706
1uy8PU5Heat shock protein HSP 90-alpha/0.705
2h55DZ8Heat shock protein HSP 90-alpha/0.703
1uyfPU1Heat shock protein HSP 90-alpha/0.699
3inxJZCHeat shock protein HSP 90-alpha/0.697
1uyhPU0Heat shock protein HSP 90-alpha/0.691
1uyePU9Heat shock protein HSP 90-alpha/0.683
1uy6PU3Heat shock protein HSP 90-alpha/0.669
3o0iP54Heat shock protein HSP 90-alpha/0.665
1uyiPUZHeat shock protein HSP 90-alpha/0.655
2ykjYKJHeat shock protein HSP 90-alpha/0.646
3ft8MOJHeat shock protein HSP 90-alpha/0.642
2ykeYKEHeat shock protein HSP 90-alpha/0.640
1uycPU7Heat shock protein HSP 90-alpha/0.628
4efuEFUHeat shock protein HSP 90-alpha/0.626
3hz5Z64Heat shock protein HSP 90-alpha/0.621
3inwJZBHeat shock protein HSP 90-alpha/0.615
3o6o94MHeat shock protein 83/0.607
3qdd94MHeat shock protein HSP 90-alpha/0.604
2ykcYKCHeat shock protein HSP 90-alpha/0.602
3d0bSNXHeat shock protein HSP 90-alpha/0.596
2qg2A91Heat shock protein HSP 90-alpha/0.595
2ykiYKIHeat shock protein HSP 90-alpha/0.594
3mnrSD1Heat shock protein HSP 90-alpha/0.592
3hz137DHeat shock protein HSP 90-alpha/0.583
2wi72KLHeat shock protein HSP 90-alpha/0.579
1uymPU3Heat shock protein HSP 90-beta/0.578
2ykbYKBHeat shock protein HSP 90-alpha/0.566
4nh82LCHeat shock protein HSP 90-alpha/0.566
4bqg50QHeat shock protein HSP 90-alpha/0.562
2wi4ZZ4Heat shock protein HSP 90-alpha/0.556
2yee2ECHeat shock protein HSP 90-alpha/0.548
4eftEFTHeat shock protein HSP 90-alpha/0.542
2yjxYJXHeat shock protein HSP 90-alpha/0.531
2yk2YJWHeat shock protein HSP 90-alpha/0.526
4awo99BHeat shock protein HSP 90-alpha/0.525
3q5kD1UHeat shock protein 83-1/0.522
3opdHIEHeat shock protein 83/0.516
2yejZZ3Heat shock protein HSP 90-alpha/0.511
2yeiXQIHeat shock protein HSP 90-alpha/0.509
2yk2YJXHeat shock protein HSP 90-alpha/0.509
4hy6FJ1Heat shock protein HSP 90-alpha/0.495
2yejXQKHeat shock protein HSP 90-alpha/0.483
4awq592Heat shock protein HSP 90-alpha/0.481
4awp99AHeat shock protein HSP 90-alpha/0.469
2xhrC0PHeat shock protein HSP 90-alpha/0.467
4bqjXKLHeat shock protein HSP 90-alpha/0.467
2qg0A94Heat shock protein HSP 90-alpha/0.462
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.461
2wi6ZZ6Heat shock protein HSP 90-alpha/0.459
3k974CDHeat shock protein HSP 90-alpha/0.459
3r4pFU7Heat shock protein HSP 90-alpha/0.452
2bt0CT5Heat shock protein HSP 90-alpha/0.451
3hyz42CHeat shock protein HSP 90-alpha/0.449
1osfKOSHeat shock protein HSP 90-alpha/0.446
1yc14BCHeat shock protein HSP 90-alpha/0.446
3whaWHAHeat shock protein HSP 90-alpha/0.443
4jqlVJ6Heat shock protein HSP 90-alpha/0.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
3ekrPY9Heat shock protein HSP 90-alpha/0.441