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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fb8215Serine/threonine-protein kinase B-raf2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fb8215Serine/threonine-protein kinase B-raf2.7.11.11.000
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.586
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.571
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.539
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.485
3cqeP91Wee1-like protein kinase2.7.10.20.468
3cr0809Wee1-like protein kinase2.7.10.20.460
3biz61EWee1-like protein kinase2.7.10.20.453
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.450
5dp2NAPCurF/0.449
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.443
2bktRPFRenin3.4.23.150.441
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.441