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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.41.000
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.619
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.617
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.616
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.596
2yquFADDihydrolipoyl dehydrogenase/0.573
3ladFADDihydrolipoyl dehydrogenase/0.571
2eq9FADDihydrolipoyl dehydrogenase/0.566
1zx9FADMercuric reductase1.16.1.10.565
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.561
3urhFADDihydrolipoyl dehydrogenase/0.554
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.552
1zk7FADMercuric reductase1.16.1.10.536
4jq9FADDihydrolipoyl dehydrogenase/0.534
2eq8FADDihydrolipoyl dehydrogenase/0.532
2r9zFADGlutathione amide reductase/0.517
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.516
3ic9FADPutative dihydrolipoamide dehydrogenase/0.491
2eq6FADDihydrolipoyl dehydrogenase/0.488
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.483
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.476
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.475
1nhpFADNADH peroxidase1.11.1.10.474
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.474
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.472
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.471
1gerFADGlutathione reductase1.8.1.70.470
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.465
3cgcFADCoenzyme A disulfide reductase/0.465
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.465
2eq7FADDihydrolipoyl dehydrogenase/0.464
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.464
1grhFADGlutathione reductase, mitochondrial1.8.1.70.460
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.457
1f8wFADNADH peroxidase1.11.1.10.455
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.455
1greFADGlutathione reductase, mitochondrial1.8.1.70.452
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.451
1grgFADGlutathione reductase, mitochondrial1.8.1.70.449
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.449
1onfFADGlutathione reductase1.8.1.70.447
3grsFADGlutathione reductase, mitochondrial1.8.1.70.447
4j56FADThioredoxin reductase 21.8.1.90.446
3cgbFADCoenzyme A disulfide reductase/0.445
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.443
4ocgFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.443
1geuFADGlutathione reductase1.8.1.70.442