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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2exmZIPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2exmZIPCyclin-dependent kinase 22.7.11.221.000
2a4lRRCCyclin-dependent kinase 22.7.11.220.612
4fklCK2Cyclin-dependent kinase 22.7.11.220.597
1w8cN69Cyclin-dependent kinase 22.7.11.220.596
1h0w207Cyclin-dependent kinase 22.7.11.220.588
2r64740Cyclin-dependent kinase 22.7.11.220.583
3qx2X63Cyclin-dependent kinase 22.7.11.220.583
3r8lZ30Cyclin-dependent kinase 22.7.11.220.582
3r8vZ62Cyclin-dependent kinase 22.7.11.220.581
3r83Z14Cyclin-dependent kinase 22.7.11.220.579
1pxjCK2Cyclin-dependent kinase 22.7.11.220.577
3rahO1ZCyclin-dependent kinase 22.7.11.220.576
2c6kDT2Cyclin-dependent kinase 22.7.11.220.574
1e1xNW1Cyclin-dependent kinase 22.7.11.220.571
1hckATPCyclin-dependent kinase 22.7.11.220.570
2c6o4SPCyclin-dependent kinase 22.7.11.220.568
2a0cCK9Cyclin-dependent kinase 22.7.11.220.566
3rpo24ZCyclin-dependent kinase 22.7.11.220.566
4erwSTUCyclin-dependent kinase 22.7.11.220.566
1oitHDTCyclin-dependent kinase 22.7.11.220.562
3r7yZ04Cyclin-dependent kinase 22.7.11.220.561
1h0vUN4Cyclin-dependent kinase 22.7.11.220.557
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.553
3lfqA28Cyclin-dependent kinase 22.7.11.220.550
2r3iSCFCyclin-dependent kinase 22.7.11.220.548
4fkv61KCyclin-dependent kinase 22.7.11.220.545
3lfnA27Cyclin-dependent kinase 22.7.11.220.544
1ke7LS3Cyclin-dependent kinase 22.7.11.220.540
2uzoC62Cyclin-dependent kinase 22.7.11.220.540
3qtzX42Cyclin-dependent kinase 22.7.11.220.540
3r73X87Cyclin-dependent kinase 22.7.11.220.539
2r3gSC9Cyclin-dependent kinase 22.7.11.220.537
3rm618ZCyclin-dependent kinase 22.7.11.220.532
2w06FRVCyclin-dependent kinase 22.7.11.220.531
3r71X86Cyclin-dependent kinase 22.7.11.220.528
1oirHDYCyclin-dependent kinase 22.7.11.220.527
2b54D05Cyclin-dependent kinase 22.7.11.220.527
2ds11CDCyclin-dependent kinase 22.7.11.220.525
2c6lDT4Cyclin-dependent kinase 22.7.11.220.523
4kd11QKCyclin-dependent kinase 22.7.11.220.523
1pyePM1Cyclin-dependent kinase 22.7.11.220.522
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.522
2c6mDT5Cyclin-dependent kinase 22.7.11.220.520
3r7vZ02Cyclin-dependent kinase 22.7.11.220.520
1b38ATPCyclin-dependent kinase 22.7.11.220.519
3rni21ZCyclin-dependent kinase 22.7.11.220.519
2r3jSCJCyclin-dependent kinase 22.7.11.220.518
2r3lSCWCyclin-dependent kinase 22.7.11.220.518
3raiX85Cyclin-dependent kinase 22.7.11.220.516
2b52D42Cyclin-dependent kinase 22.7.11.220.515
2r3fSC8Cyclin-dependent kinase 22.7.11.220.515
4acm7YGCyclin-dependent kinase 22.7.11.220.515
4ek816KCyclin-dependent kinase 22.7.11.220.513
1pxmCK5Cyclin-dependent kinase 22.7.11.220.511
3sqq99ZCyclin-dependent kinase 22.7.11.220.511
2vtsLZCCyclin-dependent kinase 22.7.11.220.510
3le62BZCyclin-dependent kinase 22.7.11.220.510
1aq1STUCyclin-dependent kinase 22.7.11.220.509
4eor4SPCyclin-dependent kinase 22.7.11.220.509
2w1hL0FCyclin-dependent kinase 22.7.11.220.508
3r7uX96Cyclin-dependent kinase 22.7.11.220.508
2w05FRTCyclin-dependent kinase 22.7.11.220.507
4fkr45KCyclin-dependent kinase 22.7.11.220.507
3s2pPMUCyclin-dependent kinase 22.7.11.220.506
2vv9IM9Cyclin-dependent kinase 22.7.11.220.505
3qwjX6ACyclin-dependent kinase 22.7.11.220.505
1v1k3FPCyclin-dependent kinase 22.7.11.220.504
2c68CT6Cyclin-dependent kinase 22.7.11.220.504
3ezrEZRCyclin-dependent kinase 22.7.11.220.504
2c5yMTWCyclin-dependent kinase 22.7.11.220.503
1oiuN76Cyclin-dependent kinase 22.7.11.220.501
3qqhX0ACyclin-dependent kinase 22.7.11.220.501
4fks46KCyclin-dependent kinase 22.7.11.220.501
2b55D31Cyclin-dependent kinase 22.7.11.220.498
3r7iX9ICyclin-dependent kinase 22.7.11.220.497
1gih1PUCyclin-dependent kinase 22.7.11.220.496
2vthLZ2Cyclin-dependent kinase 22.7.11.220.496
1pxoCK7Cyclin-dependent kinase 22.7.11.220.494
3s1h56ZCyclin-dependent kinase 22.7.11.220.494
1ke6LS2Cyclin-dependent kinase 22.7.11.220.493
1y91CT9Cyclin-dependent kinase 22.7.11.220.493
3sheI85MAP kinase-activated protein kinase 32.7.11.10.493
3qqkX02Cyclin-dependent kinase 22.7.11.220.492
3sw719KCyclin-dependent kinase 22.7.11.220.492
3qqlX03Cyclin-dependent kinase 22.7.11.220.491
1h1s4SPCyclin-dependent kinase 22.7.11.220.490
1oguST8Cyclin-dependent kinase 22.7.11.220.490
1b39ATPCyclin-dependent kinase 22.7.11.220.489
3sw418KCyclin-dependent kinase 22.7.11.220.488
4eon1ROCyclin-dependent kinase 22.7.11.220.488
1h1q2A6Cyclin-dependent kinase 22.7.11.220.486
3qziX72Cyclin-dependent kinase 22.7.11.220.486
3r1sX73Cyclin-dependent kinase 22.7.11.220.486
1ykr628Cyclin-dependent kinase 22.7.11.220.485
2uznC96Cyclin-dependent kinase 22.7.11.220.485
3qx4X4BCyclin-dependent kinase 22.7.11.220.485
3pj8404Cyclin-dependent kinase 22.7.11.220.484
3r1qX75Cyclin-dependent kinase 22.7.11.220.484
1gz8MBPCyclin-dependent kinase 22.7.11.220.483
4bcoT6QCyclin-dependent kinase 22.7.11.220.483
1g5sI17Cyclin-dependent kinase 22.7.11.220.482
3ddqRRCCyclin-dependent kinase 22.7.11.220.482
3iggEFQCyclin-dependent kinase 22.7.11.220.482
2c6iDT1Cyclin-dependent kinase 22.7.11.220.481
3qtuX44Cyclin-dependent kinase 22.7.11.220.480
3rk708ZCyclin-dependent kinase 22.7.11.220.480
4nifANPMitogen-activated protein kinase 12.7.11.240.480
2r3kSCQCyclin-dependent kinase 22.7.11.220.479
3qyw6PBMitogen-activated protein kinase 12.7.11.240.479
3r1yX76Cyclin-dependent kinase 22.7.11.220.479
2r3r6SCCyclin-dependent kinase 22.7.11.220.478
2vu3LZECyclin-dependent kinase 22.7.11.220.478
3r9nZ68Cyclin-dependent kinase 22.7.11.220.478
2c69CT8Cyclin-dependent kinase 22.7.11.220.477
2duv371Cyclin-dependent kinase 22.7.11.220.477
4eok4SPCyclin-dependent kinase 22.7.11.220.477
3lfsA07Cyclin-dependent kinase 22.7.11.220.476
3nieANPMitogen-activated protein kinase/0.476
4fkq42KCyclin-dependent kinase 22.7.11.220.475
1di8DTQCyclin-dependent kinase 22.7.11.220.474
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.474
4lyn1YGCyclin-dependent kinase 22.7.11.220.474
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2iw94SPCyclin-dependent kinase 22.7.11.220.472
2b53D23Cyclin-dependent kinase 22.7.11.220.471
2y9qANPMitogen-activated protein kinase 12.7.11.240.471
3hmm855TGF-beta receptor type-12.7.11.300.471
3nynSGVG protein-coupled receptor kinase 62.7.11.160.471
3qrtX14Cyclin-dependent kinase 22.7.11.220.471
3qruX19Cyclin-dependent kinase 22.7.11.220.471
1pxlCK4Cyclin-dependent kinase 22.7.11.220.470
1pxpCK8Cyclin-dependent kinase 22.7.11.220.470
2vtqLZACyclin-dependent kinase 22.7.11.220.470
3r9dX6BCyclin-dependent kinase 22.7.11.220.470
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.470
1y8yCT7Cyclin-dependent kinase 22.7.11.220.469
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.468
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.468
3w551FMMitogen-activated protein kinase 12.7.11.240.468
1xjdSTUProtein kinase C theta type2.7.11.130.467
3rmf20ZCyclin-dependent kinase 22.7.11.220.467
5aniES4Cyclin-dependent kinase 22.7.11.220.467
3oroAGSSerine/threonine protein kinase/0.466
3rak03ZCyclin-dependent kinase 22.7.11.220.466
3rk909ZCyclin-dependent kinase 22.7.11.220.466
4h3qANPMitogen-activated protein kinase 12.7.11.240.466
5cnnANPEpidermal growth factor receptor2.7.10.10.466
3rpv26ZCyclin-dependent kinase 22.7.11.220.465
4fko20KCyclin-dependent kinase 22.7.11.220.465
1gii1PUCyclin-dependent kinase 22.7.11.220.464
2bhhRYUCyclin-dependent kinase 22.7.11.220.464
3fz1B98Cyclin-dependent kinase 22.7.11.220.464
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.464
4hge15VTyrosine-protein kinase JAK2/0.464
3eyhIZATyrosine-protein kinase JAK1/0.463
4bgh3I6Cyclin-dependent kinase 22.7.11.220.463
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2r3mSCXCyclin-dependent kinase 22.7.11.220.462
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.462
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2p4yC03Peroxisome proliferator-activated receptor gamma/0.461
1eh4IC1Casein kinase I homolog 12.7.11.10.460
2r3p3SCCyclin-dependent kinase 22.7.11.220.460
3qtxX43Cyclin-dependent kinase 22.7.11.220.460
3r9hZ67Cyclin-dependent kinase 22.7.11.220.460
4fkw62KCyclin-dependent kinase 22.7.11.220.460
1oiyN41Cyclin-dependent kinase 22.7.11.220.459
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.459
3r8pZ46Cyclin-dependent kinase 22.7.11.220.459
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.459
5cnoANPEpidermal growth factor receptor2.7.10.10.459
3rk507ZCyclin-dependent kinase 22.7.11.220.458
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4xgxADPFAD:protein FMN transferase/0.458
2j08FADDeoxyribodipyrimidine photo-lyase4.1.99.30.457
1urwI1PCyclin-dependent kinase 22.7.11.220.456
3rjc06ZCyclin-dependent kinase 22.7.11.220.456
3eljGS7Mitogen-activated protein kinase 82.7.11.240.455
3ezvEZVCyclin-dependent kinase 22.7.11.220.455
2r3o2SCCyclin-dependent kinase 22.7.11.220.454
2r3q5SCCyclin-dependent kinase 22.7.11.220.454
2x1nX1NCyclin-dependent kinase 22.7.11.220.454
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.454
1p2a5BNCyclin-dependent kinase 22.7.11.220.453
2xmyCDKCyclin-dependent kinase 22.7.11.220.453
3rvg17PTyrosine-protein kinase JAK2/0.453
2vbdV10Isopenicillin N synthase1.21.3.10.452
2zoq5IDMitogen-activated protein kinase 32.7.11.240.452
3gxlQIGTGF-beta receptor type-12.7.11.300.452
4cfnJYMCyclin-dependent kinase 22.7.11.220.452
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.452
4cdmFADDeoxyribodipyrimidine photolyase/0.451
4fv6E57Mitogen-activated protein kinase 12.7.11.240.451
4u03GTPCyclic GMP-AMP synthase/0.451
1u3cFADCryptochrome-1/0.450
2h96893Mitogen-activated protein kinase 82.7.11.240.450
2wtkANPSTE20-related kinase adapter protein alpha/0.450
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.449
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2w17I19Cyclin-dependent kinase 22.7.11.220.448
3r8uZ31Cyclin-dependent kinase 22.7.11.220.448
1u3dFADCryptochrome-1/0.447
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.447
2uzeC95Cyclin-dependent kinase 22.7.11.220.447
3w32W32Epidermal growth factor receptor2.7.10.10.447
3clyACPFibroblast growth factor receptor 2/0.446
3nux3NVCyclin-dependent kinase 62.7.11.220.446
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.446
4ambDUDPutative glycosyl transferase/0.446
4zseANPEpidermal growth factor receptor2.7.10.10.446
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.446
5dr6SKEAurora kinase A2.7.11.10.446
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.445
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
4fmqANPMitogen-activated protein kinase 12.7.11.240.445
1w0xOLOCyclin-dependent kinase 22.7.11.220.444
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2jb4A14Isopenicillin N synthase1.21.3.10.444
3dj4UD1Bifunctional protein GlmU/0.444
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3qqgX06Cyclin-dependent kinase 22.7.11.220.444
1ownFADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
2ath3EAPeroxisome proliferator-activated receptor gamma/0.443
2zb3NDPProstaglandin reductase 21.3.1.480.443
3icsCOACoenzyme A disulfide reductase/0.443
3wblPDYCyclin-dependent kinase 22.7.11.220.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.442
1owmFADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
1u4dDBQActivated CDC42 kinase 1/0.442
1xkkFMMEpidermal growth factor receptor2.7.10.10.442
3be9P04Casein kinase II subunit alpha2.7.11.10.442
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5dozNDPJamJ/0.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3w33W19Epidermal growth factor receptor2.7.10.10.441
4bn1ADPAurora kinase A2.7.11.10.441
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.441
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.440
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.440
1sh9RITGag-Pol polyprotein3.4.23.160.440
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3ql8X01Cyclin-dependent kinase 22.7.11.220.440
3rkb12ZCyclin-dependent kinase 22.7.11.220.440
3wfjNAD2-dehydropantoate 2-reductase/0.440
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.440
4jx1CAHCamphor 5-monooxygenase1.14.15.10.440
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
4yswFADXanthine dehydrogenase/oxidase/0.440