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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.311

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3111.000
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.524
4gh5NADShort-chain dehydrogenase/reductase SDR/0.521
1xkqNDPUncharacterized protein/0.515
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.511
1iy8NADLevodione reductase/0.507
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.507
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.503
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.501
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.500
3ak4NADNADH-dependent quinuclidinone reductase/0.500
1xg5NAPDehydrogenase/reductase SDR family member 11/0.499
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.499
4fn4NADShort chain dehydrogenase/0.498
2wsbNADGalactitol dehydrogenase/0.495
5lc1NADL-threonine 3-dehydrogenase/0.494
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.492
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.492
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.491
4nbwNADShort-chain dehydrogenase/reductase SDR/0.490
1zemNADXylitol dehydrogenase/0.484
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.483
1ae1NAPTropinone reductase 1/0.482
3lqfNADGalactitol dehydrogenase/0.482
5jlaNADPutative short-chain dehydrogenase/reductase/0.482
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.481
2dteNAIGlucose 1-dehydrogenase related protein/0.479
2wdzNADGalactitol dehydrogenase/0.479
3d3wNAPL-xylulose reductase1.1.1.100.479
3rj9NADAlcohol dehydrogenase1.1.1.10.479
3w8eNAD3-hydroxybutyrate dehydrogenase/0.477
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.476
4yaiNAIC alpha-dehydrogenase/0.476
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.475
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.474
1pr9NAPL-xylulose reductase1.1.1.100.474
4yagNAIC alpha-dehydrogenase/0.474
5jy1NADPutative short-chain dehydrogenase/reductase/0.474
1wntNAPL-xylulose reductase1.1.1.100.473
3wdsNADNADH-dependent quinuclidinone reductase/0.473
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.472
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.472
3w8dNAD3-hydroxybutyrate dehydrogenase/0.472
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.472
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.471
1ipeNDPTropinone reductase 21.1.1.2360.470
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.468
3uxyNADShort-chain dehydrogenase/reductase SDR/0.468
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
3a4vNADNDP-sugar epimerase/0.467
3toxNAPPutative oxidoreductase/0.467
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.466
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
3rj5NADAlcohol dehydrogenase1.1.1.10.466
4j7xNAPSepiapterin reductase1.1.1.1530.466
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.465
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.464
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.464
3l77NJPShort-chain alcohol dehydrogenase/0.464
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.464
3vdqNAD3-hydroxybutyrate dehydrogenase/0.464
3s55NADPutative short-chain dehydrogenase/reductase/0.463
3w8fNAD3-hydroxybutyrate dehydrogenase/0.463
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3ai2NDPNADPH-sorbose reductase/0.462
4j7uNAPSepiapterin reductase1.1.1.1530.461
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.461
1mg5NAIAlcohol dehydrogenase1.1.1.10.460
1w4zNAPPutative ketoacyl reductase1.3.10.460
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.459
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.459
3a1nNADNDP-sugar epimerase/0.459
4dc1NDPPutative ketoacyl reductase1.3.10.459
4qecNAPElxO/0.459
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.458
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.457
4b79NADProbable short-chain dehydrogenase/0.456
5idwNAPShort-chain dehydrogenase/reductase SDR/0.456
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.455
4hwkNAPSepiapterin reductase1.1.1.1530.455
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.454
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.453
1b15NAEAlcohol dehydrogenase1.1.1.10.452
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.452
5jydNADShort chain dehydrogenase/0.452
1b16NAQAlcohol dehydrogenase1.1.1.10.450
1g6kNADGlucose 1-dehydrogenase1.1.1.470.448
1n5dNDPCarbonyl reductase [NADPH] 1/0.447
3sx2NADUncharacterized protein/0.447
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.447
1geeNADGlucose 1-dehydrogenase1.1.1.470.445
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.445
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.445
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.444
1sbyNADAlcohol dehydrogenase1.1.1.10.443
3f1kNAPUncharacterized oxidoreductase YciK10.442
3tscNADUncharacterized protein/0.442
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.442
3ai3NDPNADPH-sorbose reductase/0.441
2yy7NADL-threonine dehydrogenase/0.440
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.440