Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ewaSB2Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ewaSB2Mitogen-activated protein kinase 14/1.000
3lfeZ84Mitogen-activated protein kinase 14/0.548
3hv3R49Mitogen-activated protein kinase 14/0.537
3l8sBFFMitogen-activated protein kinase 14/0.534
3gcq1BUMitogen-activated protein kinase 14/0.523
3lfcZ86Mitogen-activated protein kinase 14/0.515
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.506
2bakAQZMitogen-activated protein kinase 14/0.502
4a9yAQZMitogen-activated protein kinase 14/0.502
3cv9VDXVitamin D3 dihydroxylase/0.500
3zsgT75Mitogen-activated protein kinase 14/0.500
1ouk084Mitogen-activated protein kinase 14/0.499
1ywrLI9Mitogen-activated protein kinase 14/0.497
1pkfEPDEpothilone C/D epoxidase1.140.494
3hucG97Mitogen-activated protein kinase 14/0.490
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.488
1blzACVIsopenicillin N synthase1.21.3.10.487
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.487
2bjsACVIsopenicillin N synthase1.21.3.10.486
4iarERM5-hydroxytryptamine receptor 1B/0.485
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.484
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.483
4f9wLM4Mitogen-activated protein kinase 14/0.483
1hb1OCVIsopenicillin N synthase1.21.3.10.481
3iw8HIZMitogen-activated protein kinase 14/0.480
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.480
1q5dEPBEpothilone C/D epoxidase1.140.478
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.476
3q2mCKISpectinomycin phosphotransferase/0.475
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.475
1ouy094Mitogen-activated protein kinase 14/0.471
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
4eh60ONMitogen-activated protein kinase 14/0.470
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
4iaq2GM5-hydroxytryptamine receptor 1B/0.468
4g95OAGDihydrofolate reductase1.5.1.30.466
2jb4A14Isopenicillin N synthase1.21.3.10.465
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
3gcpSB2Mitogen-activated protein kinase 14/0.465
3qm4PN0Cytochrome P450 2D6/0.465
4h9753SDihydrofolate reductase1.5.1.30.465
1bk0ACVIsopenicillin N synthase1.21.3.10.464
1qiqACCIsopenicillin N synthase1.21.3.10.464
2hw2RFPRifampin ADP-ribosyl transferase/0.464
3htjETEbrA repressor/0.464
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.464
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.463
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
3eta351Insulin receptor2.7.10.10.462
3p9tTCLRepressor/0.462
3zoiM2WIsopenicillin N synthase1.21.3.10.462
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.462
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
3ctj320Hepatocyte growth factor receptor2.7.10.10.461
3oafOAGDihydrofolate reductase1.5.1.30.461
3sgy06WDihydrofolate reductase1.5.1.30.461
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.460
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.460
3abaFLICytochrome P450/0.460
3n61XFJNitric oxide synthase, brain1.14.13.390.460
3nxyD2HDihydrofolate reductase1.5.1.30.460
1dr3HBIDihydrofolate reductase1.5.1.30.458
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.458
4ixeIXEDihydrofolate reductase1.5.1.30.458
1oc1ASVIsopenicillin N synthase1.21.3.10.457
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.457
3hz5Z64Heat shock protein HSP 90-alpha/0.457
3jwm5WBDihydrofolate reductase/0.457
3qly55VUncharacterized protein/0.457
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.457
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
1uzwCDHIsopenicillin N synthase1.21.3.10.456
1w06W05Isopenicillin N synthase1.21.3.10.456
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4b7sQLECytochrome P450 monooxygenase PikC/0.456
1hb3SCVIsopenicillin N synthase1.21.3.10.455
3o9lLPNRenin3.4.23.150.455
3zk5Z18Cytochrome P450 monooxygenase PikC/0.455
4j6dTESCytochrome P450 monooxygenase/0.455
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.455
3pwhZMAAdenosine receptor A2a/0.455
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.454
2y6fM9FIsopenicillin N synthase1.21.3.10.454
3qls55VDihydrofolate reductase1.5.1.30.454
3t8xT8XT-cell surface glycoprotein CD1b/0.454
4dlj6RGMitogen-activated protein kinase 14/0.454
4qa0SHHHistone deacetylase 83.5.1.980.454
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
3td8D2RDihydrofolate reductase1.5.1.30.453
3zkyWT4Isopenicillin N synthase1.21.3.10.453
4hni16WCasein kinase I isoform epsilon2.7.11.10.453
4luxQJ8Nitric oxide synthase, brain1.14.13.390.453
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2iviACWIsopenicillin N synthase1.21.3.10.452
2uxhQUEHTH-type transcriptional regulator TtgR/0.452
3d4bDZDNAD-dependent protein deacetylase/0.452
3tmz06XCytochrome P450 2B41.14.14.10.452
4ixfIXFDihydrofolate reductase1.5.1.30.452
3uzcT4EAdenosine receptor A2a/0.452
1f4gTP4Thymidylate synthase/0.451
3fln3FNMitogen-activated protein kinase 14/0.451
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
3w0tHPULactoylglutathione lyase4.4.1.50.451
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4rbs0RVMetallo-beta-lactamase type 2/0.451
3reyXACAdenosine receptor A2a/0.451
2bu9HFVIsopenicillin N synthase1.21.3.10.450
2fs4PZ1Renin3.4.23.150.450
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3mpaSB2Mitogen-activated protein kinase 14/0.450
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.450
4rupH97Vitamin D3 receptor A/0.450
1xddAAYIntegrin alpha-L/0.449
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2fzhDH1Dihydrofolate reductase1.5.1.30.449
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4fnyI3KALK tyrosine kinase receptor2.7.10.10.449
1odnAPVIsopenicillin N synthase1.21.3.10.448
3n65XFJNitric oxide synthase, brain1.14.13.390.448
3nxvD2FDihydrofolate reductase1.5.1.30.448
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.448
4bwaN0BPyrrolysine--tRNA ligase/0.448
4eh70OOMitogen-activated protein kinase 14/0.448
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.447
1tduCB3Thymidylate synthase/0.447
2g263LGRenin3.4.23.150.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
2y60M8FIsopenicillin N synthase1.21.3.10.447
3p99LNPLanosterol 14-alpha-demethylase/0.447
3tdaPN0Cytochrome P450 2D6/0.447
1aoeGW3Dihydrofolate reductase1.5.1.30.446
2ghmLICMitogen-activated protein kinase 14/0.446
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
3nxtD2EDihydrofolate reductase1.5.1.30.446
3zs5SB2Mitogen-activated protein kinase 14/0.446
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4jsfQJ4Nitric oxide synthase, brain1.14.13.390.446
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.445
3gc7B45Mitogen-activated protein kinase 14/0.445
4ewqMWLMitogen-activated protein kinase 14/0.445
4ybnFADFlavin-nucleotide-binding protein/0.445
2vbdV10Isopenicillin N synthase1.21.3.10.444
3frdDHFDihydrofolate reductase1.5.1.30.444
3n5xXFKNitric oxide synthase, brain1.14.13.390.444
1eioGCHGastrotropin/0.443
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.443
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.443
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
4b2gV1NUncharacterized protein/0.443
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4j6bPLOCytochrome P450 monooxygenase/0.443
5gcnCOAHAT A1/0.443
1crbRTLRetinol-binding protein 1/0.442
1x8b824Wee1-like protein kinase2.7.10.20.442
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3tubFPUTyrosine-protein kinase SYK2.7.10.20.442
3up3XCAaceDAF-12/0.442
4equG6ISerine/threonine-protein kinase 102.7.11.10.442
5dp2NAPCurF/0.442
1x8lOXRRetinol dehydratase/0.441
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3cth319Hepatocyte growth factor receptor2.7.10.10.441
3dt1P40Mitogen-activated protein kinase 14/0.441
3gc9B45Mitogen-activated protein kinase 112.7.11.240.441
3pqbVGPPutative oxidoreductase/0.441
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.441
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.441
3qj5022Alcohol dehydrogenase class-31.1.1.10.441
3r3b4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.441
3slkNDPPolyketide synthase extender module 2/0.441
3v94WYQPhosphodiesterase/0.441
4j6cSTRCytochrome P450 monooxygenase/0.441
1qjfACSIsopenicillin N synthase1.21.3.10.440
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
3jwcEKBDihydrofolate reductase/0.440
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4ea13RXDehydrosqualene synthase/0.440
4h9506UDihydrofolate reductase1.5.1.30.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440