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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2eq7FADDihydrolipoyl dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2eq7FADDihydrolipoyl dehydrogenase/1.000
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.556
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.555
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.547
1geuFADGlutathione reductase1.8.1.70.541
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.541
2yquFADDihydrolipoyl dehydrogenase/0.539
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.536
3urhFADDihydrolipoyl dehydrogenase/0.529
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.527
4jq9FADDihydrolipoyl dehydrogenase/0.521
1zx9FADMercuric reductase1.16.1.10.518
3ladFADDihydrolipoyl dehydrogenase/0.518
2eq9FADDihydrolipoyl dehydrogenase/0.516
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.512
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.511
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.511
1zk7FADMercuric reductase1.16.1.10.508
2rabFADGlutathione amide reductase/0.501
2r9zFADGlutathione amide reductase/0.496
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.496
1grbFADGlutathione reductase, mitochondrial1.8.1.70.490
1gerFADGlutathione reductase1.8.1.70.488
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.487
3grsFADGlutathione reductase, mitochondrial1.8.1.70.482
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.479
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.479
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.478
1getFADGlutathione reductase1.8.1.70.476
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.476
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.474
1greFADGlutathione reductase, mitochondrial1.8.1.70.473
1grhFADGlutathione reductase, mitochondrial1.8.1.70.472
1graFADGlutathione reductase, mitochondrial1.8.1.70.470
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.469
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.468
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.468
1grgFADGlutathione reductase, mitochondrial1.8.1.70.466
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.466
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.466
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.465
1joaFADNADH peroxidase1.11.1.10.463
4j56FADThioredoxin reductase 21.8.1.90.463
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.462
1onfFADGlutathione reductase1.8.1.70.460
2eq8FADDihydrolipoyl dehydrogenase/0.460
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.459
1feaFADTrypanothione reductase1.8.1.120.454
1nhqFADNADH peroxidase1.11.1.10.453
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.453
1febFADTrypanothione reductase1.8.1.120.447
1nhpFADNADH peroxidase1.11.1.10.446
2v6oFADThioredoxin glutathione reductase/0.446
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.443
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.442
1nhsFADNADH peroxidase1.11.1.10.442
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.441
4nevFADTrypanothione reductase/0.441
2c3cFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.440