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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2en5SAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2en5SAHDiphthine synthase/1.000
2e8qSAHDiphthine synthase/0.887
2ek7SAHDiphthine synthase/0.878
2pb4SAHDiphthine synthase/0.862
2e16SAHDiphthine synthase/0.842
2dxwSAHDiphthine synthase/0.815
2e8sSAHDiphthine synthase/0.805
2eglSAHDiphthine synthase/0.805
2pcmSAHDiphthine synthase/0.803
2dxvSAHDiphthine synthase/0.796
2pb6SAHDiphthine synthase/0.790
2emrSAHDiphthine synthase/0.783
2pchSAHDiphthine synthase/0.776
2el0SAHDiphthine synthase/0.774
2emuSAHDiphthine synthase/0.773
2huxSAHDiphthine synthase/0.763
2eh5SAHDiphthine synthase/0.759
2dv3SAHDiphthine synthase/0.741
2dsgSAHDiphthine synthase/0.740
2ek4SAHDiphthine synthase/0.739
2e4nSAHDiphthine synthase/0.726
2owvSAHDiphthine synthase/0.722
2dv7SAHDiphthine synthase/0.720
2ed5SAHDiphthine synthase/0.719
2ehlSAHDiphthine synthase/0.717
2eldSAHDiphthine synthase/0.716
2dv4SAHDiphthine synthase/0.712
2pcaSAHDiphthine synthase/0.710
2el3SAHDiphthine synthase/0.709
1wngSAHDiphthine synthase/0.708
2dekSAHDiphthine synthase/0.707
2p6dSAHDiphthine synthase/0.703
2eniSAHDiphthine synthase/0.700
2p6kSAHDiphthine synthase/0.700
2p6lSAHDiphthine synthase/0.697
2ejkSAHDiphthine synthase/0.695
2e8hSAHDiphthine synthase/0.679
2pcgSAHDiphthine synthase/0.679
2ek2SAHDiphthine synthase/0.677
2p2xSAHDiphthine synthase/0.672
2egsSAHDiphthine synthase/0.668
2ekaSAHDiphthine synthase/0.668
1vceSAHDiphthine synthase/0.666
2ejjSAHDiphthine synthase/0.662
2owkSAHDiphthine synthase/0.662
2eh2SAHDiphthine synthase/0.659
2eh4SAHDiphthine synthase/0.658
2hr8SAHDiphthine synthase/0.657
2egbSAHDiphthine synthase/0.654
2p9dSAHDiphthine synthase/0.654
2e7rSAHDiphthine synthase/0.653
2pciSAHDiphthine synthase/0.650
2dxxSAHDiphthine synthase/0.644
2huvSAHDiphthine synthase/0.640
2owgSAHDiphthine synthase/0.633
2p5cSAHDiphthine synthase/0.633
2e08SAHDiphthine synthase/0.632
2p5fSAHDiphthine synthase/0.625
2eleSAHDiphthine synthase/0.623
2e8rSAHDiphthine synthase/0.617
2pb5SAHDiphthine synthase/0.616
2owuSAHDiphthine synthase/0.614
2z6rSAHDiphthine synthase/0.612
2dshSAHDiphthine synthase/0.608
2pckSAHDiphthine synthase/0.606
2dsiSAHDiphthine synthase/0.604
2owfSAHDiphthine synthase/0.604
2e07SAHDiphthine synthase/0.601
2e17SAHDiphthine synthase/0.595
2eeqSAHDiphthine synthase/0.585
2p6iSAHDiphthine synthase/0.568
2dv5SAHDiphthine synthase/0.567
2hutSAHDiphthine synthase/0.567
2huqSAHDiphthine synthase/0.565
2ed3SAHDiphthine synthase/0.560
2ejzSAHDiphthine synthase/0.558
2ek3SAHDiphthine synthase/0.544
1xe55FEPlasmepsin-23.4.23.390.505
3ig6438Urokinase-type plasminogen activator3.4.21.730.505
2e15SAHDiphthine synthase/0.504
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.499
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.497
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.496
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.492
2q5g1FAPeroxisome proliferator-activated receptor delta/0.490
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.490
3ijoB4DGlutamate receptor 2/0.489
2xhd7T9Glutamate receptor 2/0.488
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.488
4ipw1G7Mycocyclosin synthase1.14.21.90.488
2iyfERYOleandomycin glycosyltransferase2.4.10.487
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.487
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.487
2a94AP0L-lactate dehydrogenase1.1.1.270.486
3gw9VNILanosterol 14-alpha-demethylase/0.486
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.486
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.485
3clrFADElectron transfer flavoprotein subunit alpha/0.485
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.485
1g63FMNEpidermin decarboxylase4.1.10.484
4h3f10OBeta-secretase 13.4.23.460.482
1x1aSAMC-20 methyltransferase/0.481
2qbuSAHPrecorrin-2 methyltransferase/0.481
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.481
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.481
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.480
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.480
3a3gDLZLumazine protein/0.480
3to6LYS_CMCHistone acetyltransferase ESA1/0.479
4ji91M3Tyrosine-protein kinase JAK2/0.479
1e1qANPATP synthase subunit alpha, mitochondrial/0.478
1e1qANPATP synthase subunit beta, mitochondrial3.6.3.140.478
1xe65FPPlasmepsin-23.4.23.390.478
3hl0NADMaleylacetate reductase/0.478
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.477
3nsh957Beta-secretase 13.4.23.460.477
4g7gVFVLanosterol 14-alpha-demethylase/0.477
4i0i957Beta-secretase 13.4.23.460.477
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.477
4xr9NADCalS8/0.477
1g1aNADdTDP-glucose 4,6-dehydratase/0.476
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
4bfzZVZPantothenate kinase2.7.1.330.476
1f8fNADBenzyl alcohol dehydrogenase/0.475
2g1s4IGRenin3.4.23.150.475
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.475
4eb7PLPCysteine desulfurase IscS 2/0.475
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.475
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.475
5d3qGDPDynamin-13.6.5.50.475
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.474
4a8v2ANMajor pollen allergen Bet v 1-J/0.474
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.474
4q71FADBifunctional protein PutA/0.474
5af7FADAcyl-CoA dehydrogenase/0.474
2ifaFMNUncharacterized protein/0.473
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.473
4egbNADdTDP-glucose 4,6-dehydratase/0.473
1ma0NADAlcohol dehydrogenase class-31.1.1.10.472
1w6hTITPlasmepsin-23.4.23.390.472
4nbwNADShort-chain dehydrogenase/reductase SDR/0.472
1dirNADDihydropteridine reductase1.5.1.340.471
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.471
1pd9CO4Dihydrofolate reductase1.5.1.30.471
2gjlFMNNitronate monooxygenase1.13.12.160.471
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.471
3lpjZ75Beta-secretase 13.4.23.460.471
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.471
1fxsNAPGDP-L-fucose synthase/0.470
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.470
1ur5NADMalate dehydrogenase/0.470
2vkeTACTetracycline repressor protein class D/0.470
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.470
3vqsJT1Genome polyprotein/0.470
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
1h8hATPATP synthase subunit alpha, mitochondrial/0.469
1h8hATPATP synthase subunit beta, mitochondrial3.6.3.140.469
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.469
1lbcCYZGlutamate receptor 2/0.469
1x1dSAHC-20 methyltransferase/0.469
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.469
3oibFDAPutative acyl-CoA dehydrogenase/0.469
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.469
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.469
5irnADPNucleotide binding oligomerization domain containing 2/0.469
1f8wFADNADH peroxidase1.11.1.10.468
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.468
1o97FADElectron transfer flavoprotein subunit alpha/0.468
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.468
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.468
2wo7ASVIsopenicillin N synthase1.21.3.10.468
3d91REMRenin3.4.23.150.468
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
2c20NADUDP-glucose 4-epimerase/0.467
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.467
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.467
1nzdUPGDNA beta-glucosyltransferase/0.466
1t2cNAIL-lactate dehydrogenase1.1.1.270.466
2pj4414Carboxypeptidase B/0.466
3c1y2BADNA integrity scanning protein DisA/0.466
4oqyNDP(S)-imine reductase/0.466
4yxm2BADNA integrity scanning protein DisA/0.466
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.465
4wudANPDNA gyrase subunit B/0.465
1orrNADCDP-paratose 2-epimerase/0.464
1x1cSAHC-20 methyltransferase/0.464
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2ebaFADPutative glutaryl-CoA dehydrogenase/0.464
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.464
2p5uNADUDP-glucose 4-epimerase/0.464
2y60M8FIsopenicillin N synthase1.21.3.10.464
2zjmF1MBeta-secretase 13.4.23.460.464
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
1kp3ATPArgininosuccinate synthase6.3.4.50.463
1pjcNADAlanine dehydrogenase/0.463
2dftADPShikimate kinase2.7.1.710.463
2fznFADBifunctional protein PutA1.5.5.20.463
2oapANPType II secretion system protein (GspE-2)/0.463
3s1dZIRCytokinin dehydrogenase 11.5.99.120.463
3t1tGDPProbable gliding protein mglA/0.463
3wmxNADNAD dependent epimerase/dehydratase/0.463
3zoiM2WIsopenicillin N synthase1.21.3.10.463
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
1y4lSVRBasic phospholipase A2 homolog 2/0.462
2hu2NADC-terminal binding protein 1/0.462
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.462
3f3sNADLambda-crystallin homolog/0.462
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.462
3lqfNADGalactitol dehydrogenase/0.462
4f5yC2EStimulator of interferon genes protein/0.462
4h3j10WBeta-secretase 13.4.23.460.462
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.462
4xguADPPutative pachytene checkpoint protein 2/0.462
2p83MR0Beta-secretase 13.4.23.460.461
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.461
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.461
2y3sTIRTamL/0.461
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.461
4b65FADL-ornithine N(5)-monooxygenase/0.461
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.461
4i1iNADMalate dehydrogenase/0.461
4m83ERYOleandomycin glycosyltransferase2.4.10.461
5hwsNAP2-dehydropantoate 2-reductase/0.461
1udaUFGUDP-glucose 4-epimerase5.1.3.20.460
2irzI02Beta-secretase 13.4.23.460.460
2zvcSAHPrecorrin-3 C17-methyltransferase/0.460
4dh60KNBeta-secretase 13.4.23.460.460
4du82P0Mevalonate diphosphate decarboxylase/0.460
1bxoPP7Penicillopepsin-13.4.23.200.459
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.459
2he5NDPAldo-keto reductase family 1 member C211.1.10.459
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.459
3qfrFMNNADPH--cytochrome P450 reductase/0.459
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.459
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.459
4r21STRCytochrome P450 family 17 polypeptide 2/0.459
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.458
1cf3FADGlucose oxidase1.1.3.40.458
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.458
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.458
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.458
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.458
3clsFADElectron transfer flavoprotein subunit alpha/0.458
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3frqERYErythromycin resistance repressor protein/0.458
3ik6HCZGlutamate receptor 2/0.458
3ivgFG5Pantothenate synthetase6.3.2.10.458
3jv7NADSecondary alcohol dehydrogenase/0.458
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3orfNADDihydropteridine reductase1.5.1.340.458
4a83DXCMajor pollen allergen Bet v 1-A/0.458
4i8zG08Gag-Pol polyprotein3.4.23.160.458
1bwsNDPGDP-L-fucose synthase/0.457
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1xddAAYIntegrin alpha-L/0.457
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
2x06NADL-sulfolactate dehydrogenase/0.457
2zvbSAHPrecorrin-3 C17-methyltransferase/0.457
3lpiZ74Beta-secretase 13.4.23.460.457
3t3c017Gag-Pol polyprotein3.4.23.160.457
4djy0KRBeta-secretase 13.4.23.460.457
1cdoNADAlcohol dehydrogenase 11.1.1.10.456
1omoNADAlanine dehydrogenase/0.456
1tqf32PBeta-secretase 13.4.23.460.456
2gv8NDPThiol-specific monooxygenase1.14.130.456
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.456
2xx91NFGlutamate receptor 2/0.456
3d8bADPFidgetin-like protein 13.6.40.456
3toh079Gag-Pol polyprotein2.7.7.490.456
1y0s331Peroxisome proliferator-activated receptor delta/0.455
2ahrNAPPyrroline-5-carboxylate reductase/0.455
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.455
2g1o2IGRenin3.4.23.150.455
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.455
2rcyNAPPyrroline-5-carboxylate reductase/0.455
2z54AB1Gag-Pol polyprotein3.4.23.160.455
3ad9NADSubunit alpha of sarocosine oxidase/0.455
3ai3NDPNADPH-sorbose reductase/0.455
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3omuIBDHeat shock protein 83/0.455
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.455
4irnFADAnaB/0.455
4lutDCSAlanine racemase/0.455
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.455
4prvADPDNA gyrase subunit B/0.455
1me6IVSPlasmepsin-23.4.23.390.454
1mp0NADAlcohol dehydrogenase class-31.1.1.10.454
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.454
2b53D23Cyclin-dependent kinase 22.7.11.220.454
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.454
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.454
2znnS44Peroxisome proliferator-activated receptor alpha/0.454
3cic316Beta-secretase 13.4.23.460.454
3lpkZ76Beta-secretase 13.4.23.460.454
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.454
3zkyWT4Isopenicillin N synthase1.21.3.10.454
4a862ANMajor pollen allergen Bet v 1-A/0.454
4bfvZVVPantothenate kinase2.7.1.330.454
4dbzNDPPutative ketoacyl reductase1.3.10.454
5f8eSAHPossible transcriptional regulatory protein/0.454
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.453
1ja0FMNNADPH--cytochrome P450 reductase/0.453
1juvNDPDihydrofolate reductase1.5.1.30.453
1x1bSAHC-20 methyltransferase/0.453
2ntrL00Beta-secretase 13.4.23.460.453
2ovhAS0Progesterone receptor/0.453
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
2v7qATPATP synthase subunit alpha, mitochondrial/0.453
2v7qATPATP synthase subunit beta, mitochondrial3.6.3.140.453
3p8zSAHGenome polyprotein2.1.1.560.453
3pndFADFAD:protein FMN transferase/0.453
4g3jVNTLanosterol 14-alpha-demethylase/0.453
4ips1G4Mycocyclosin synthase1.14.21.90.453
4wriOKAOkadaic acid binding protein 2-alpha/0.453
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1hdrNADDihydropteridine reductase1.5.1.340.452
1phgMYTCamphor 5-monooxygenase1.14.15.10.452
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.452
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.452
2jb4A14Isopenicillin N synthase1.21.3.10.452
2qo9ANPEphrin type-A receptor 32.7.10.10.452
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.452
2xfsJ01Uncharacterized protein/0.452
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.452
3nmpPYVAbscisic acid receptor PYL2/0.452
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.452
4acxS8ZBeta-secretase 13.4.23.460.452
4bfxZVXPantothenate kinase2.7.1.330.452
4ejvLCLTranscriptional regulator TcaR/0.452
4k6fNAPPutative Acetoacetyl-CoA reductase/0.452
1bim0QBRenin3.4.23.150.451
1dhrNADDihydropteridine reductase1.5.1.340.451
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.451
1nhhANPDNA mismatch repair protein MutL/0.451
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.451
1tj0FADBifunctional protein PutA1.5.5.20.451
1yqzCOACoenzyme A disulfide reductase/0.451
2f81017Gag-Pol polyprotein3.4.23.160.451
2g21L1BRenin3.4.23.150.451
2znpK55Peroxisome proliferator-activated receptor delta/0.451
3cib314Beta-secretase 13.4.23.460.451
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.451
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.451
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.451
3p67FMNPentaerythritol tetranitrate reductase/0.451
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
5dp2NAPCurF/0.451
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
1bmfANPATP synthase subunit alpha, mitochondrial/0.450
1bmfANPATP synthase subunit beta, mitochondrial3.6.3.140.450
1lf3EH5Plasmepsin-23.4.23.390.450
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.450
1qrpHH0Pepsin A-43.4.23.10.450
1yb5NAPQuinone oxidoreductase1.6.5.50.450
2rlcCHDCholoylglycine hydrolase3.5.1.240.450
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.450
4kne1CYDihydrofolate reductase1.5.1.30.450
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1lf2R37Plasmepsin-23.4.23.390.449
2a5kAZPReplicase polyprotein 1ab3.4.220.449
2b7aIZATyrosine-protein kinase JAK2/0.449
2bn4FMNNADPH--cytochrome P450 reductase/0.449
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.449
2g1y5IGRenin3.4.23.150.449
2g247IGRenin3.4.23.150.449
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.449
2is0I03Beta-secretase 13.4.23.460.449
2xfiXFIBeta-secretase 13.4.23.460.449
3kb6NADD-lactate dehydrogenase/0.449
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.449
3mk6ACOPantothenate kinase 32.7.1.330.449
3zh8C58Protein kinase C iota type2.7.11.130.449
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.449
4tuvCPZCytochrome P450 1191.140.449
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.449
5c1gGDUHisto-blood group ABO system transferase/0.449
5jscFADPutative acyl-CoA dehydrogenase/0.449
1jedADPSulfate adenylyltransferase/0.448
1nzfUPGDNA beta-glucosyltransferase/0.448
1psa0ZLPepsin A3.4.23.10.448
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.448
2rh9IGPTryptophan synthase alpha chain/0.448
2w06FRVCyclin-dependent kinase 22.7.11.220.448
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
3e8xNAPBH1520 protein/0.448
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.448
3oht1N1Mitogen-activated protein kinase/0.448
3r9uFADThioredoxin reductase/0.448
4dx9SER_ALA_VAL_THRIntegrin beta-1/0.448
4dx9SER_ALA_VAL_THRIntegrin beta-1-binding protein 1/0.448
4fv7E94Mitogen-activated protein kinase 12.7.11.240.448
4iv6FDAIsovaleryl-CoA dehydrogenase/0.448
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.448
5a0yCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.448
5a0yCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.448
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.448
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.447
1g6kNADGlucose 1-dehydrogenase1.1.1.470.447
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1udbUFGUDP-glucose 4-epimerase5.1.3.20.447
1uzwCDHIsopenicillin N synthase1.21.3.10.447
2bu9HFVIsopenicillin N synthase1.21.3.10.447
2ep7NADGlyceraldehyde-3-phosphate dehydrogenase/0.447
2ien017Gag-Pol polyprotein3.4.23.160.447
2ikuLIYRenin3.4.23.150.447
3d3xARG_ILE_MET_GLU_NH2Type E botulinum toxin/0.447
3djjFADGlutathione reductase, mitochondrial1.8.1.70.447
3in6FMNUncharacterized protein/0.447
3ixj586Beta-secretase 13.4.23.460.447
3uayADNPurine nucleoside phosphorylase DeoD-type/0.447
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.447
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.447
3wb2YGPUncharacterized protein MJ0488/0.447
4ccrFADThioredoxin reductase/0.447
4ejmNAPPutative zinc-binding dehydrogenase/0.447
4enhFVXCholesterol 24-hydroxylase/0.447
4h3g10QBeta-secretase 13.4.23.460.447
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.447
1qy5NECEndoplasmin/0.446
2g226IGRenin3.4.23.150.446
2hfuMEVMevalonate kinase/0.446
2uxoTACHTH-type transcriptional regulator TtgR/0.446
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.446
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.446
3b6zCO7Enoyl reductase LovC10.446
3hyoADPPyridoxal kinase/0.446
3o0o5ADVitamin B12-dependent ribonucleotide reductase/0.446
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
4b4vL34Bifunctional protein FolD/0.446
4yqfGDPSeptin-9/0.446
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.445
1e3eNAIAlcohol dehydrogenase 41.1.1.10.445
1h50FMNPentaerythritol tetranitrate reductase/0.445
1msmJE2Gag-Pol polyprotein3.4.23.160.445
1obnASVIsopenicillin N synthase1.21.3.10.445
1qjfACSIsopenicillin N synthase1.21.3.10.445
1t7j478Gag-Pol polyprotein3.4.23.160.445
1xs7MMIBeta-secretase 13.4.23.460.445
1zioAP5Adenylate kinase/0.445
2ck3ANPATP synthase subunit alpha, mitochondrial/0.445
2ck3ANPATP synthase subunit beta, mitochondrial3.6.3.140.445
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.445
2iqgF2IBeta-secretase 13.4.23.460.445
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.445
2vn0TDZCytochrome P450 2C8/0.445
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.445
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.445
3own3OWRenin3.4.23.150.445
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.445
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.445
3sf6FDAGlutaryl-CoA dehydrogenase/0.445
4ambDUDPutative glycosyl transferase/0.445
4b78KGGBeta-secretase 13.4.23.460.445
4dc0NDPPutative ketoacyl reductase1.3.10.445
4dpy2P0Mevalonate diphosphate decarboxylase/0.445
4esoNAPPutative oxidoreductase/0.445
4exg916Beta-secretase 13.4.23.460.445
4q0kGA3Phytohormone-binding protein/0.445
4xgxADPFAD:protein FMN transferase/0.445
4yaoFMNNADPH--cytochrome P450 reductase/0.445
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.445
5c1mCLRMu-type opioid receptor/0.445
1bdlIM1Gag-Pol polyprotein3.4.23.160.444
1bil0IURenin3.4.23.150.444
1cjtFOKAdenylate cyclase type 2/0.444
1cjtFOKAdenylate cyclase type 5/0.444
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.444
1ohhANPATP synthase subunit alpha, mitochondrial/0.444
1ohhANPATP synthase subunit beta, mitochondrial3.6.3.140.444
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.444
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.444
1u3cFADCryptochrome-1/0.444
2a92NAIL-lactate dehydrogenase/0.444
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3cltFADElectron transfer flavoprotein subunit alpha/0.444
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
3fznD7KBenzoylformate decarboxylase4.1.1.70.444
3gwfNAPCyclohexanone monooxygenase/0.444
3h2sNDPPutative NADH-flavin reductase/0.444
3k5c0BIBeta-secretase 13.4.23.460.444
3oqfS51Renin3.4.23.150.444
3owaFADAcyl-CoA dehydrogenase/0.444
3qt62P0Mevalonate diphosphate decarboxylase/0.444
3tneRITCandidapepsin-13.4.23.240.444
4bb3KKAIsopenicillin N synthase1.21.3.10.444
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.444
4dpf0LGBeta-secretase 13.4.23.460.444
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.444
4frkDWDBeta-secretase 13.4.23.460.444
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.444
4lcjNADC-terminal-binding protein 2/0.444
4wucANPDNA gyrase subunit B/0.444
4yaiNAIC alpha-dehydrogenase/0.444
1rneC60Renin3.4.23.150.443
2bf4FMNNADPH--cytochrome P450 reductase/0.443
2c29NAPDihydroflavonol 4-reductase/0.443
2gjnFMNNitronate monooxygenase1.13.12.160.443
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.443
2op9WR1Orf1ab polyprotein/0.443
2vbdV10Isopenicillin N synthase1.21.3.10.443
2wedPP6Penicillopepsin-13.4.23.200.443
2ylzFADPhenylacetone monooxygenase1.14.13.920.443
3cid318Beta-secretase 13.4.23.460.443
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3h06VBPGlutamate receptor 2/0.443
3nutSAHPrecorrin-3 methylase/0.443
4b1rITCTetracycline repressor protein class D/0.443
4rquNADAlcohol dehydrogenase class-P/0.443
4yagNAIC alpha-dehydrogenase/0.443
1bdmNAXMalate dehydrogenase/0.442
1hbvGANGag-Pol polyprotein/0.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
1vikBAYGag-Pol polyprotein/0.442
2a9y26AAdenosine kinase2.7.1.200.442
2c27ACOMycothiol acetyltransferase2.3.1.1890.442
2czfXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.442
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.442
2ovmAS0Progesterone receptor/0.442
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.442
3dv5BAVBeta-secretase 13.4.23.460.442
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.442
3hy9098A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.442
3i25MV7Beta-secretase 13.4.23.460.442
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.442
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.442
3nw3MU2Peptidoglycan recognition protein 1/0.442
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.442
3tjzGNPADP-ribosylation factor 1/0.442
3wagTYDGlycosyltransferase/0.442
4a81DXCMajor pollen allergen Bet v 1-A/0.442
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4emtC2EStimulator of interferon genes protein/0.442
4j75TYMTryptophan--tRNA ligase/0.442
4m4922YL-lactate dehydrogenase A chain1.1.1.270.442
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.442
1beuIPLTryptophan synthase alpha chain/0.441
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1drhNAPDihydrofolate reductase1.5.1.30.441
1hzjUD1UDP-glucose 4-epimerase/0.441
1xvaSAMGlycine N-methyltransferase2.1.1.200.441
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.441
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.441
2fj1CTCTetracycline repressor protein class D/0.441
2gtbAZPOrf1ab polyprotein/0.441
2hk9NAPShikimate dehydrogenase (NADP(+))/0.441
2iko7IGRenin3.4.23.150.441
2il2LIXRenin3.4.23.150.441
2q4bNAPUncharacterized protein At5g02240/0.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
2xveFADPutative flavin-containing monooxygenase/0.441
2yyeAPCSelenide, water dikinase2.7.9.30.441
3ahn3A1Oligopeptidase/0.441
3c212BADNA integrity scanning protein DisA/0.441
3d3wNAPL-xylulose reductase1.1.1.100.441
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
3iltTRUGlutamate receptor 2/0.441
3lzs017Gag-Pol polyprotein3.4.23.160.441
3qwbNDPProbable quinone oxidoreductase1.6.5.50.441
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.441
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.440
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.440
2npfMOUElongation factor 2/0.440
2q7vFADThioredoxin reductase/0.440
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.440
2vwhNAPGlucose 1-dehydrogenase/0.440
2wecPP5Penicillopepsin-13.4.23.200.440
2wf1ZY1Beta-secretase 13.4.23.460.440
2xlrFADPutative flavin-containing monooxygenase/0.440
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3fktSIIBeta-secretase 13.4.23.460.440
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.440
3ohh3HHBeta-secretase 13.4.23.460.440
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.440
3uylTYDProbable NDP-rhamnosyltransferase/0.440
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
4kgkGTPUncharacterized protein/0.440
4l0qNADAlcohol dehydrogenase class-3/0.440
4ohwATPProtein clpf-1/0.440
4yvz3ATDNA integrity scanning protein DisA/0.440
4djhJDCKappa-type opioid receptor/0.440