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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/1.000
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.549
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.528
1ae1NAPTropinone reductase 1/0.523
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.517
1pr9NAPL-xylulose reductase1.1.1.100.509
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.498
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.498
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.497
3gy0NAPNAD(P)-dependent oxidoreductase/0.495
5jlaNADPutative short-chain dehydrogenase/reductase/0.493
1wntNAPL-xylulose reductase1.1.1.100.492
4dc1NDPPutative ketoacyl reductase1.3.10.491
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.490
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.489
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.489
1w4zNAPPutative ketoacyl reductase1.3.10.488
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.488
4j7xNAPSepiapterin reductase1.1.1.1530.488
1n5dNDPCarbonyl reductase [NADPH] 1/0.487
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.486
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.485
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.485
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.485
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.483
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.482
3qrwNDPPutative ketoacyl reductase1.3.10.482
1ipeNDPTropinone reductase 21.1.1.2360.479
4j7uNAPSepiapterin reductase1.1.1.1530.478
1sbyNADAlcohol dehydrogenase1.1.1.10.477
1x7gNAPPutative ketoacyl reductase1.3.10.477
1rwbNADGlucose 1-dehydrogenase1.1.1.470.475
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.473
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.473
3vdqNAD3-hydroxybutyrate dehydrogenase/0.473
4hwkNAPSepiapterin reductase1.1.1.1530.473
4yaiNAIC alpha-dehydrogenase/0.473
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.472
3w8dNAD3-hydroxybutyrate dehydrogenase/0.472
5idwNAPShort-chain dehydrogenase/reductase SDR/0.470
1x7hNDPPutative ketoacyl reductase1.3.10.469
2wdzNADGalactitol dehydrogenase/0.469
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.469
3p19NDPPutative blue fluorescent protein/0.469
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.469
5lc1NADL-threonine 3-dehydrogenase/0.469
1geeNADGlucose 1-dehydrogenase1.1.1.470.467
4gh5NADShort-chain dehydrogenase/reductase SDR/0.467
2dteNAIGlucose 1-dehydrogenase related protein/0.466
3tn7NJPShort-chain alcohol dehydrogenase/0.466
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.463
1rkxNADCDP-D-glucose-4,6-dehydratase/0.463
2wsbNADGalactitol dehydrogenase/0.463
1gcoNADGlucose 1-dehydrogenase1.1.1.470.462
1iy8NADLevodione reductase/0.461
1oaaNAPSepiapterin reductase1.1.1.1530.460
1snyNAPLD36273p/0.460
3w8eNAD3-hydroxybutyrate dehydrogenase/0.460
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.460
1xg5NAPDehydrogenase/reductase SDR family member 11/0.459
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.459
3l77NJPShort-chain alcohol dehydrogenase/0.458
3uceNDPDehydrogenase/0.457
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.456
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.455
3sjuNDPKeto reductase/0.455
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.455
4yagNAIC alpha-dehydrogenase/0.454
2yutNAPPutative short-chain oxidoreductase/0.453
3f1kNAPUncharacterized oxidoreductase YciK10.453
3wdsNADNADH-dependent quinuclidinone reductase/0.453
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.451
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.451
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.451
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
2bd0NAPSepiapterin reductase/0.450
3d3wNAPL-xylulose reductase1.1.1.100.450
3toxNAPPutative oxidoreductase/0.450
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.450
1mg5NAIAlcohol dehydrogenase1.1.1.10.449
3bmoNAPPteridine reductase/0.447
4qecNAPElxO/0.447
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.446
5jydNADShort chain dehydrogenase/0.445
3a4vNADNDP-sugar epimerase/0.444
4bmvNAPShort-chain dehydrogenase/0.444
5dbfNDPIridoid synthase1.3.1.990.444
2jahNDPClavaldehyde dehydrogenase/0.443
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.443
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.443
5emhNAPIridoid synthase1.3.1.990.443
1xq6NAPUncharacterized protein At5g02240/0.442
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.442
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1xkqNDPUncharacterized protein/0.440