sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2eit | NAD | 1-pyrroline-5-carboxylate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2eit | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 1.000 | |
| 2j40 | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.865 | |
| 2j5n | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.857 | |
| 2eii | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.847 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.792 | |
| 2bhp | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.708 | |
| 2ehq | NAP | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.689 | |
| 3n82 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.590 | |
| 2onp | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.584 | |
| 4fqf | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.576 | |
| 4pz2 | NAD | Aldehyde dehydrogenase 2-6 | / | 0.560 | |
| 2bja | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.557 | |
| 1nzw | NAI | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.556 | |
| 1o02 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.555 | |
| 1nzz | NAI | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.553 | |
| 1o00 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.544 | |
| 5eyu | NAD | Betaine-aldehyde dehydrogenase | / | 0.544 | |
| 4v37 | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.543 | |
| 4pxl | NAD | Aldehyde dehydrogenase3 | / | 0.540 | |
| 4x4l | NAI | Retinal dehydrogenase 1 | 1.2.1.36 | 0.539 | |
| 2onm | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.532 | |
| 3iwk | NAD | Aminoaldehyde dehydrogenase | / | 0.531 | |
| 4fr8 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.520 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.518 | |
| 4pt0 | NAD | Aldehyde dehydrogenase | / | 0.515 | |
| 4zz7 | NAD | Methylmalonate-semialdehyde dehydrogenase | / | 0.512 | |
| 1nzx | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.511 | |
| 1o04 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.511 | |
| 4wb9 | NAI | Retinal dehydrogenase 1 | 1.2.1.36 | 0.510 | |
| 1cw3 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.508 | |
| 4fr8 | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.502 | |
| 1wnb | NAI | Gamma-aminobutyraldehyde dehydrogenase | 1.2.1.19 | 0.500 | |
| 3haz | NAD | Bifunctional protein PutA | / | 0.500 | |
| 1bxs | NAD | Retinal dehydrogenase 1 | 1.2.1.36 | 0.496 | |
| 4i1w | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.494 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.480 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.468 | |
| 3v9l | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.467 | |
| 3n83 | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.464 | |
| 4pt3 | NDP | Aldehyde dehydrogenase | / | 0.460 | |
| 4i9b | NAD | Putative betaine aldehyde dehyrogenase | / | 0.458 | |
| 1ad3 | NAD | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.455 | |
| 1t90 | NAD | Malonate-semialdehyde dehydrogenase | 1.2.1.27 | 0.455 | |
| 4oe2 | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.455 | |
| 3ju8 | NAD | N-succinylglutamate 5-semialdehyde dehydrogenase | 1.2.1.71 | 0.453 | |
| 4x2q | NAD | Retinal dehydrogenase 2 | 1.2.1.36 | 0.452 | |
| 4go2 | TAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.446 |