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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2egsSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2egsSAHDiphthine synthase/1.000
2egbSAHDiphthine synthase/0.883
2p5fSAHDiphthine synthase/0.838
2p2xSAHDiphthine synthase/0.831
2dxwSAHDiphthine synthase/0.828
2ejkSAHDiphthine synthase/0.827
2dxvSAHDiphthine synthase/0.821
2p6kSAHDiphthine synthase/0.821
2p5cSAHDiphthine synthase/0.817
2dv7SAHDiphthine synthase/0.813
2ed5SAHDiphthine synthase/0.801
2e7rSAHDiphthine synthase/0.795
2eniSAHDiphthine synthase/0.787
2eglSAHDiphthine synthase/0.773
2p6dSAHDiphthine synthase/0.773
2e08SAHDiphthine synthase/0.767
2emrSAHDiphthine synthase/0.765
2el0SAHDiphthine synthase/0.757
2dxxSAHDiphthine synthase/0.756
2ekaSAHDiphthine synthase/0.755
2eh5SAHDiphthine synthase/0.747
2dsiSAHDiphthine synthase/0.746
2owkSAHDiphthine synthase/0.746
2pcmSAHDiphthine synthase/0.744
2ek7SAHDiphthine synthase/0.737
2ehlSAHDiphthine synthase/0.736
2eleSAHDiphthine synthase/0.735
2owuSAHDiphthine synthase/0.735
2pb5SAHDiphthine synthase/0.735
2e8sSAHDiphthine synthase/0.734
2pb4SAHDiphthine synthase/0.727
2dv4SAHDiphthine synthase/0.721
2pcgSAHDiphthine synthase/0.721
2hutSAHDiphthine synthase/0.716
2pckSAHDiphthine synthase/0.715
2emuSAHDiphthine synthase/0.712
2dv5SAHDiphthine synthase/0.709
2p6iSAHDiphthine synthase/0.708
2dsgSAHDiphthine synthase/0.703
2owvSAHDiphthine synthase/0.700
2e8hSAHDiphthine synthase/0.695
2pchSAHDiphthine synthase/0.694
2owgSAHDiphthine synthase/0.690
1vceSAHDiphthine synthase/0.688
2eh2SAHDiphthine synthase/0.687
2eeqSAHDiphthine synthase/0.686
2hr8SAHDiphthine synthase/0.685
2ek3SAHDiphthine synthase/0.682
1wngSAHDiphthine synthase/0.679
2e16SAHDiphthine synthase/0.675
2e8qSAHDiphthine synthase/0.673
2en5SAHDiphthine synthase/0.661
2dshSAHDiphthine synthase/0.658
2dekSAHDiphthine synthase/0.656
2p9dSAHDiphthine synthase/0.651
2dv3SAHDiphthine synthase/0.639
2huqSAHDiphthine synthase/0.638
2huvSAHDiphthine synthase/0.637
2pcaSAHDiphthine synthase/0.637
2huxSAHDiphthine synthase/0.636
2pciSAHDiphthine synthase/0.632
2ejjSAHDiphthine synthase/0.628
2e07SAHDiphthine synthase/0.620
2z6rSAHDiphthine synthase/0.619
2e17SAHDiphthine synthase/0.618
2e15SAHDiphthine synthase/0.612
2ek2SAHDiphthine synthase/0.611
2eh4SAHDiphthine synthase/0.602
2e8rSAHDiphthine synthase/0.598
2ed3SAHDiphthine synthase/0.592
2p6lSAHDiphthine synthase/0.591
2eldSAHDiphthine synthase/0.579
2owfSAHDiphthine synthase/0.577
2ek4SAHDiphthine synthase/0.573
2pb6SAHDiphthine synthase/0.570
2el3SAHDiphthine synthase/0.568
2e4nSAHDiphthine synthase/0.567
2ejzSAHDiphthine synthase/0.554
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.522
1zeoC01Peroxisome proliferator-activated receptor gamma/0.503
3bc3OPTCathepsin L13.4.22.150.502
1lbcCYZGlutamate receptor 2/0.498
4g7gVFVLanosterol 14-alpha-demethylase/0.495
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.493
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.491
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.490
4a8v2ANMajor pollen allergen Bet v 1-J/0.490
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
3ixp834Ecdysone receptor/0.489
1tqf32PBeta-secretase 13.4.23.460.488
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.488
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.487
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.487
1f20FADNitric oxide synthase, brain1.14.13.390.486
3gw9VNILanosterol 14-alpha-demethylase/0.486
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.485
1g1aNADdTDP-glucose 4,6-dehydratase/0.483
2xhd7T9Glutamate receptor 2/0.483
2ifaFMNUncharacterized protein/0.482
1xe55FEPlasmepsin-23.4.23.390.481
4nbwNADShort-chain dehydrogenase/reductase SDR/0.481
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.480
1dirNADDihydropteridine reductase1.5.1.340.479
2q4bNAPUncharacterized protein At5g02240/0.479
2q5g1FAPeroxisome proliferator-activated receptor delta/0.479
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.479
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.477
4h3j10WBeta-secretase 13.4.23.460.477
4i1iNADMalate dehydrogenase/0.477
1kkq471Peroxisome proliferator-activated receptor alpha/0.476
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.476
1w6hTITPlasmepsin-23.4.23.390.476
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.475
1me6IVSPlasmepsin-23.4.23.390.475
1phgMYTCamphor 5-monooxygenase1.14.15.10.475
4djy0KRBeta-secretase 13.4.23.460.475
4a81DXCMajor pollen allergen Bet v 1-A/0.474
4wudANPDNA gyrase subunit B/0.474
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.473
2a94AP0L-lactate dehydrogenase1.1.1.270.473
3lpjZ75Beta-secretase 13.4.23.460.473
4a6nFADTetX family tetracycline inactivation enzyme/0.473
1f8fNADBenzyl alcohol dehydrogenase/0.472
2fznFADBifunctional protein PutA1.5.5.20.472
2ovhAS0Progesterone receptor/0.472
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.472
3ut5LOCTubulin beta chain/0.472
1tj0FADBifunctional protein PutA1.5.5.20.470
1xe65FPPlasmepsin-23.4.23.390.470
2gjlFMNNitronate monooxygenase1.13.12.160.470
2pswCOAN-alpha-acetyltransferase 50/0.470
4a83DXCMajor pollen allergen Bet v 1-A/0.470
4bfzZVZPantothenate kinase2.7.1.330.470
4ewo996Beta-secretase 13.4.23.460.470
1bk0ACVIsopenicillin N synthase1.21.3.10.469
2w06FRVCyclin-dependent kinase 22.7.11.220.469
3oqfS51Renin3.4.23.150.469
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.469
1culFOKAdenylate cyclase type 2/0.468
1culFOKAdenylate cyclase type 5/0.468
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.468
1orrNADCDP-paratose 2-epimerase/0.468
1x1aSAMC-20 methyltransferase/0.468
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.468
2dftADPShikimate kinase2.7.1.710.468
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.468
2rhgIGPTryptophan synthase alpha chain/0.468
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.468
3zh8C58Protein kinase C iota type2.7.11.130.468
4wriOKAOkadaic acid binding protein 2-alpha/0.468
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.467
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.467
3cid318Beta-secretase 13.4.23.460.467
3d4pNADL-lactate dehydrogenase 11.1.1.270.467
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.467
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.467
4g3jVNTLanosterol 14-alpha-demethylase/0.467
1udaUFGUDP-glucose 4-epimerase5.1.3.20.466
3ig6438Urokinase-type plasminogen activator3.4.21.730.466
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.466
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.465
3vdqNAD3-hydroxybutyrate dehydrogenase/0.465
3vqsJT1Genome polyprotein/0.465
4irnFADAnaB/0.465
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.465
1bwsNDPGDP-L-fucose synthase/0.464
1xddAAYIntegrin alpha-L/0.464
1xl5190Gag-Pol polyprotein3.4.23.160.464
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.464
2qbuSAHPrecorrin-2 methyltransferase/0.464
3ajrNADNDP-sugar epimerase/0.464
3b70NAPEnoyl reductase LovC10.464
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.464
4i8zG08Gag-Pol polyprotein3.4.23.160.464
1nzdUPGDNA beta-glucosyltransferase/0.463
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.463
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.463
2iviACWIsopenicillin N synthase1.21.3.10.463
3a1nNADNDP-sugar epimerase/0.463
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.463
3lpkZ76Beta-secretase 13.4.23.460.463
3pndFADFAD:protein FMN transferase/0.463
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.463
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4bfxZVXPantothenate kinase2.7.1.330.463
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.463
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.462
1ja0FMNNADPH--cytochrome P450 reductase/0.462
2po7CHDFerrochelatase, mitochondrial4.99.1.10.462
3hl0NADMaleylacetate reductase/0.462
1f8wFADNADH peroxidase1.11.1.10.461
1vikBAYGag-Pol polyprotein/0.461
2a5kAZPReplicase polyprotein 1ab3.4.220.461
2b53D23Cyclin-dependent kinase 22.7.11.220.461
2givACOHistone acetyltransferase KAT8/0.461
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
1eh4IC1Casein kinase I homolog 12.7.11.10.460
1hdrNADDihydropteridine reductase1.5.1.340.460
1t88CAMCamphor 5-monooxygenase1.14.15.10.460
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.460
2g1r3IGRenin3.4.23.150.460
2gv8NDPThiol-specific monooxygenase1.14.130.460
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
3el01UNGag-Pol polyprotein3.4.23.160.460
3ggfGVDSerine/threonine-protein kinase 26/0.460
3ijoB4DGlutamate receptor 2/0.460
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.460
3wb2YGPUncharacterized protein MJ0488/0.460
3wv9FEGHmd co-occurring protein HcgE/0.460
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.460
4exg916Beta-secretase 13.4.23.460.460
4m83ERYOleandomycin glycosyltransferase2.4.10.460
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.460
1g63FMNEpidermin decarboxylase4.1.10.459
1h8hATPATP synthase subunit alpha, mitochondrial/0.459
1h8hATPATP synthase subunit beta, mitochondrial3.6.3.140.459
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.459
2bjfDXCCholoylglycine hydrolase3.5.1.240.459
2he5NDPAldo-keto reductase family 1 member C211.1.10.459
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.459
3uylTYDProbable NDP-rhamnosyltransferase/0.459
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.459
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.459
1hbvGANGag-Pol polyprotein/0.458
1t2cNAIL-lactate dehydrogenase1.1.1.270.458
1x1cSAHC-20 methyltransferase/0.458
1zdwFLVPrenyltransferase/0.458
2oapANPType II secretion system protein (GspE-2)/0.458
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.458
3h06VBPGlutamate receptor 2/0.458
3ik6HCZGlutamate receptor 2/0.458
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.458
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.458
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
4kb9G79Protease/0.458
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
5d3qGDPDynamin-13.6.5.50.458
1pjcNADAlanine dehydrogenase/0.457
2c29NAPDihydroflavonol 4-reductase/0.457
3a3gDLZLumazine protein/0.457
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3k5fAYHBeta-secretase 13.4.23.460.457
3r9uFADThioredoxin reductase/0.457
4egbNADdTDP-glucose 4,6-dehydratase/0.457
4ipw1G7Mycocyclosin synthase1.14.21.90.457
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2a87FADThioredoxin reductase1.8.1.90.456
2iyfERYOleandomycin glycosyltransferase2.4.10.456
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.456
3jziJZLBiotin carboxylase6.3.4.140.456
3lshFADPyranose 2-oxidase/0.456
3oht1N1Mitogen-activated protein kinase/0.456
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.456
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.456
4y3jHICEndothiapepsin3.4.23.220.456
1geeNADGlucose 1-dehydrogenase1.1.1.470.455
1lf3EH5Plasmepsin-23.4.23.390.455
1ma0NADAlcohol dehydrogenase class-31.1.1.10.455
1nhhANPDNA mismatch repair protein MutL/0.455
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.455
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.455
3c1y2BADNA integrity scanning protein DisA/0.455
3jynNDPQuinone oxidoreductase/0.455
3phjDHKShikimate dehydrogenase (NADP(+))/0.455
3slkNDPPolyketide synthase extender module 2/0.455
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.455
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.455
4ji91M3Tyrosine-protein kinase JAK2/0.455
5fm7ADPRuvB-like helicase/0.455
1bxoPP7Penicillopepsin-13.4.23.200.454
1cf3FADGlucose oxidase1.1.3.40.454
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1qorNDPQuinone oxidoreductase 1/0.454
1t7j478Gag-Pol polyprotein3.4.23.160.454
1x1dSAHC-20 methyltransferase/0.454
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.454
2bu9HFVIsopenicillin N synthase1.21.3.10.454
2ft9CHDFatty acid-binding protein 2, liver/0.454
2g1o2IGRenin3.4.23.150.454
2npxFADNADH peroxidase1.11.1.10.454
2p83MR0Beta-secretase 13.4.23.460.454
2pj4414Carboxypeptidase B/0.454
2znq401Peroxisome proliferator-activated receptor delta/0.454
3oibFDAPutative acyl-CoA dehydrogenase/0.454
3own3OWRenin3.4.23.150.454
3phiNDPShikimate dehydrogenase (NADP(+))/0.454
4bftZVTPantothenate kinase2.7.1.330.454
4dpf0LGBeta-secretase 13.4.23.460.454
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.454
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.454
4oqyNDP(S)-imine reductase/0.454
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.454
1bim0QBRenin3.4.23.150.453
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.453
1v9aSAHUncharacterized protein/0.453
1yb5NAPQuinone oxidoreductase1.6.5.50.453
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.453
2g1n1IGRenin3.4.23.150.453
2rcyNAPPyrroline-5-carboxylate reductase/0.453
2rlcCHDCholoylglycine hydrolase3.5.1.240.453
3h3t16HCollagen type IV alpha-3-binding protein/0.453
3orfNADDihydropteridine reductase1.5.1.340.453
3owaFADAcyl-CoA dehydrogenase/0.453
4b78KGGBeta-secretase 13.4.23.460.453
4h3f10OBeta-secretase 13.4.23.460.453
1beuIPLTryptophan synthase alpha chain/0.452
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.452
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.452
1mp0NADAlcohol dehydrogenase class-31.1.1.10.452
1qjfACSIsopenicillin N synthase1.21.3.10.452
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.452
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.452
2g20L1ARenin3.4.23.150.452
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.452
2ylzFADPhenylacetone monooxygenase1.14.13.920.452
2zvbSAHPrecorrin-3 C17-methyltransferase/0.452
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3lpiZ74Beta-secretase 13.4.23.460.452
3sdi3SDProteasome subunit beta type-53.4.25.10.452
3sdi3SDProteasome subunit beta type-63.4.25.10.452
3sdkP3NProteasome subunit beta type-53.4.25.10.452
3sdkP3NProteasome subunit beta type-63.4.25.10.452
3zkyWT4Isopenicillin N synthase1.21.3.10.452
4b8zNAPGDP-L-fucose synthase1.1.1.2710.452
4dpuAGSMevalonate diphosphate decarboxylase/0.452
4qxr1YEStimulator of interferon genes protein/0.452
4xr9NADCalS8/0.452
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1xq6NAPUncharacterized protein At5g02240/0.451
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.451
2p5uNADUDP-glucose 4-epimerase/0.451
3duyAFJBeta-secretase 13.4.23.460.451
3ekp478Gag-Pol polyprotein3.4.23.160.451
3f3sNADLambda-crystallin homolog/0.451
3lqfNADGalactitol dehydrogenase/0.451
3rk507ZCyclin-dependent kinase 22.7.11.220.451
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.451
3zuyTCHTransporter/0.451
4bb3KKAIsopenicillin N synthase1.21.3.10.451
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.451
4frkDWDBeta-secretase 13.4.23.460.451
4gxs0YSGlutamate receptor 2/0.451
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.451
4n9iPCGCatabolite expression activator/0.451
5cyoGDPSeptin-9/0.451
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.450
1obbNADAlpha-glucosidase3.2.1.200.450
2b7aIZATyrosine-protein kinase JAK2/0.450
2g1s4IGRenin3.4.23.150.450
2vbdV10Isopenicillin N synthase1.21.3.10.450
2znoS44Peroxisome proliferator-activated receptor gamma/0.450
2zvcSAHPrecorrin-3 C17-methyltransferase/0.450
3d91REMRenin3.4.23.150.450
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.450
3l63CAMCamphor 5-monooxygenase1.14.15.10.450
3oqkS52Renin3.4.23.150.450
3p3zP3ZPutative cytochrome P450/0.450
3t3r9PLCytochrome P450 2A61.14.130.450
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.450
4xumIMNPeroxisome proliferator-activated receptor gamma/0.450
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.450
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1juvNDPDihydrofolate reductase1.5.1.30.449
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.449
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.449
1qiqACCIsopenicillin N synthase1.21.3.10.449
1x1bSAHC-20 methyltransferase/0.449
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.449
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.449
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
2wo7ASVIsopenicillin N synthase1.21.3.10.449
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.449
2xfsJ01Uncharacterized protein/0.449
2y0mACOHistone acetyltransferase KAT8/0.449
3adaNADSubunit alpha of sarocosine oxidase/0.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.449
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.449
4fv7E94Mitogen-activated protein kinase 12.7.11.240.449
4qecNAPElxO/0.449
4xguADPPutative pachytene checkpoint protein 2/0.449
5c1mCLRMu-type opioid receptor/0.449
1bmfANPATP synthase subunit alpha, mitochondrial/0.448
1bmfANPATP synthase subunit beta, mitochondrial3.6.3.140.448
1bw9NADPhenylalanine dehydrogenase/0.448
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.448
1ptjNAPNAD(P) transhydrogenase subunit beta1.6.1.20.448
1xvaSAMGlycine N-methyltransferase2.1.1.200.448
2ahrNAPPyrroline-5-carboxylate reductase/0.448
2fdpFRPBeta-secretase 13.4.23.460.448
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.448
2p3b3TLV-1 PROTEASE protein/0.448
2p3b3TLV-1 protease/0.448
2yj5ATPCopper-transporting ATPase/0.448
2z54AB1Gag-Pol polyprotein3.4.23.160.448
3fwjCAMCamphor 5-monooxygenase1.14.15.10.448
3gqvNAPEnoyl reductase LovC10.448
3gwfNAPCyclohexanone monooxygenase/0.448
3omuIBDHeat shock protein 83/0.448
3to6LYS_CMCHistone acetyltransferase ESA1/0.448
3w8eNAD3-hydroxybutyrate dehydrogenase/0.448
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.448
4f081RSTyrosine-protein kinase JAK2/0.448
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.448
4yqfGDPSeptin-9/0.448
5dp2NAPCurF/0.448
1e1qANPATP synthase subunit alpha, mitochondrial/0.447
1e1qANPATP synthase subunit beta, mitochondrial3.6.3.140.447
1fy7COAHistone acetyltransferase ESA1/0.447
1likADNAdenosine kinase2.7.1.200.447
1sxjAGSReplication factor C subunit 1/0.447
1vsoAT1Glutamate receptor ionotropic, kainate 1/0.447
2dvlFADAcyl-CoA dehydrogenase/0.447
2dwbANPAurora kinase A2.7.11.10.447
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.447
2gz8F3FOrf1a polyprotein/0.447
2ou2ACOHistone acetyltransferase KAT5/0.447
2q7vFADThioredoxin reductase/0.447
3clsFADElectron transfer flavoprotein subunit alpha/0.447
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.447
3tdj3TJGlutamate receptor 2/0.447
3tneRITCandidapepsin-13.4.23.240.447
4dbzNDPPutative ketoacyl reductase1.3.10.447
4f5yC2EStimulator of interferon genes protein/0.447
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.447
4ips1G4Mycocyclosin synthase1.14.21.90.447
4mv8ACPBiotin carboxylase6.3.4.140.447
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.447
4px9ADPATP-dependent RNA helicase DDX3X3.6.4.130.447
4xldBRLPeroxisome proliferator-activated receptor gamma/0.447
1bygSTUTyrosine-protein kinase CSK/0.446
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.446
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.446
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.446
2ph835ABeta-secretase 13.4.23.460.446
2uxuNARHTH-type transcriptional regulator TtgR/0.446
2xx91NFGlutamate receptor 2/0.446
2y65ADPKinesin heavy chain/0.446
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.446
3hyz42CHeat shock protein HSP 90-alpha/0.446
3iaeD7KBenzaldehyde lyase/0.446
3ixj586Beta-secretase 13.4.23.460.446
3sufSUEPolyprotein/0.446
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.446
4du82P0Mevalonate diphosphate decarboxylase/0.446
4dx9SER_ALA_VAL_THRIntegrin beta-1/0.446
4dx9SER_ALA_VAL_THRIntegrin beta-1-binding protein 1/0.446
4gl4NAIAlcohol dehydrogenase class-3/0.446
4h3zSAHtRNA (guanine-N(1)-)-methyltransferase/0.446
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.446
4yaoFMNNADPH--cytochrome P450 reductase/0.446
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.446
1drhNAPDihydrofolate reductase1.5.1.30.445
1h73ANPHomoserine kinase2.7.1.390.445
1mjaCOAHistone acetyltransferase ESA1/0.445
1nzfUPGDNA beta-glucosyltransferase/0.445
1phhFADp-hydroxybenzoate hydroxylase/0.445
1rneC60Renin3.4.23.150.445
1vbiNADMalate/L-lactate dehydrogenase family protein/0.445
1xl2189Gag-Pol polyprotein3.4.23.160.445
1zioAP5Adenylate kinase/0.445
2g247IGRenin3.4.23.150.445
2ikuLIYRenin3.4.23.150.445
2qbmCAMCamphor 5-monooxygenase1.14.15.10.445
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.445
2w3bNDPDihydrofolate reductase1.5.1.30.445
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.445
3oeeANPATP synthase subunit alpha, mitochondrial/0.445
3oeeANPATP synthase subunit beta, mitochondrial3.6.3.140.445
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.445
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.445
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.445
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4iae1DXAlr2278 protein/0.445
4qxq1YEStimulator of interferon genes protein/0.445
4zohFADPutative oxidoreductase FAD-binding subunit/0.445
1ay0TPPTransketolase 12.2.1.10.444
1g6kNADGlucose 1-dehydrogenase1.1.1.470.444
1jipKTN6-deoxyerythronolide B hydroxylase/0.444
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.444
1nooCAHCamphor 5-monooxygenase1.14.15.10.444
1obnASVIsopenicillin N synthase1.21.3.10.444
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.444
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.444
1yrdCAMCamphor 5-monooxygenase1.14.15.10.444
1z1fSTLResveratrol synthase/0.444
2gz7D3FOrf1a polyprotein/0.444
2hk9NAPShikimate dehydrogenase (NADP(+))/0.444
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.444
2npaMMBPeroxisome proliferator-activated receptor alpha/0.444
2p8hMY9Beta-secretase 13.4.23.460.444
2qo9ANPEphrin type-A receptor 32.7.10.10.444
2y4gTIRTamL/0.444
2ym1FADPhenylacetone monooxygenase1.14.13.920.444
2znnS44Peroxisome proliferator-activated receptor alpha/0.444
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.444
3cic316Beta-secretase 13.4.23.460.444
3d7kD7KBenzaldehyde lyase/0.444
3oev3OEProteasome subunit beta type-53.4.25.10.444
3oev3OEProteasome subunit beta type-63.4.25.10.444
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.444
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.444
3so9017Pol protein/0.444
4b7xNAPProbable oxidoreductase/0.444
4df2FMNNADPH dehydrogenase/0.444
4enhFVXCholesterol 24-hydroxylase/0.444
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.444
4opuFDAConserved Archaeal protein/0.444
4yxm2BADNA integrity scanning protein DisA/0.444
5irnADPNucleotide binding oligomerization domain containing 2/0.444
1lbbKAIGlutamate receptor 2/0.443
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.443
1u3cFADCryptochrome-1/0.443
2bn4FMNNADPH--cytochrome P450 reductase/0.443
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.443
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.443
2vnaNAPProstaglandin reductase 21.3.1.480.443
3crzFADFerredoxin--NADP+ reductase/0.443
3djjFADGlutathione reductase, mitochondrial1.8.1.70.443
3em3478Gag-Pol polyprotein3.4.23.160.443
3fhxPXLPyridoxal kinase2.7.1.350.443
3fwfCAMCamphor 5-monooxygenase1.14.15.10.443
3i25MV7Beta-secretase 13.4.23.460.443
3il1B5DGlutamate receptor 2/0.443
3lb8FADPutidaredoxin reductase1.18.1.50.443
3lzs017Gag-Pol polyprotein3.4.23.160.443
3p62FMNPentaerythritol tetranitrate reductase/0.443
3pwm017Gag-Pol polyprotein3.4.23.160.443
3qbhQBHBeta-secretase 13.4.23.460.443
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.443
4a862ANMajor pollen allergen Bet v 1-A/0.443
4acxS8ZBeta-secretase 13.4.23.460.443
4ambDUDPutative glycosyl transferase/0.443
4b1bFADThioredoxin reductase1.8.1.90.443
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.443
4loi1YCStimulator of interferon genes protein/0.443
5hwsNAP2-dehydropantoate 2-reductase/0.443
1cdoNADAlcohol dehydrogenase 11.1.1.10.442
1e3eNAIAlcohol dehydrogenase 41.1.1.10.442
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.442
1msmJE2Gag-Pol polyprotein3.4.23.160.442
1rx1NAPDihydrofolate reductase1.5.1.30.442
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.442
1t85CAMCamphor 5-monooxygenase1.14.15.10.442
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.442
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.442
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2c20NADUDP-glucose 4-epimerase/0.442
2fy4COACholine O-acetyltransferase2.3.1.60.442
2gr1FADFerredoxin reductase/0.442
2hizLIJBeta-secretase 13.4.23.460.442
2ph6712Beta-secretase 13.4.23.460.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.442
3e8xNAPBH1520 protein/0.442
3i6iNDPPutative leucoanthocyanidin reductase 1/0.442
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.442
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.442
3ohh3HHBeta-secretase 13.4.23.460.442
3wrjCAMCamphor 5-monooxygenase1.14.15.10.442
4cdmFO1Deoxyribodipyrimidine photolyase/0.442
4dfg0JVGag-Pol polyprotein3.4.23.160.442
4dpy2P0Mevalonate diphosphate decarboxylase/0.442
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.442
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.442
4ure1PSCyclohexanol dehydrogenase/0.442
4uyf73BBromodomain-containing protein 2/0.442
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.442
1bil0IURenin3.4.23.150.441
1i3mUD1UDP-glucose 4-epimerase/0.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1kp3ATPArgininosuccinate synthase6.3.4.50.441
1mj9COAHistone acetyltransferase ESA1/0.441
2ep7NADGlyceraldehyde-3-phosphate dehydrogenase/0.441
2fy5SOPCholine O-acetyltransferase2.3.1.60.441
2ilvC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.441
2is0I03Beta-secretase 13.4.23.460.441
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.441
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.441
2uxpCLMHTH-type transcriptional regulator TtgR/0.441
2yxuATPPyridoxal kinase2.7.1.350.441
3d5m4MSGenome polyprotein2.7.7.480.441
3in6FMNUncharacterized protein/0.441
3p7nFMNLight-activated DNA-binding protein EL222/0.441
3r4b74TGag-Pol polyprotein/0.441
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.441
3tyvHI3Genome polyprotein2.7.7.480.441
4a4qUX9Pol protein/0.441
4b1rITCTetracycline repressor protein class D/0.441
4u0mGTPCyclic GMP-AMP synthase/0.441
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
4yntFDAGlucose oxidase, putative/0.441
5ftcADPTPR domain protein/0.441
1dr3TAPDihydrofolate reductase1.5.1.30.440
1rfuADPPyridoxal kinase2.7.1.350.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
1ybmNAPUncharacterized protein At5g02240/0.440
2ien017Gag-Pol polyprotein3.4.23.160.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
2ovmAS0Progesterone receptor/0.440
2rh9IGPTryptophan synthase alpha chain/0.440
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2vwqNAPGlucose 1-dehydrogenase/0.440
2xtnGTPGTPase IMAP family member 2/0.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.440
3d8bADPFidgetin-like protein 13.6.40.440
3dv5BAVBeta-secretase 13.4.23.460.440
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3h86AP5Adenylate kinase/0.440
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.440
3qlrNDPDihydrofolate reductase1.5.1.30.440
3rvg17PTyrosine-protein kinase JAK2/0.440
3zoiM2WIsopenicillin N synthase1.21.3.10.440
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
4g2fC07Ephrin type-A receptor 32.7.10.10.440
4i1nFOLDihydrofolate reductase1.5.1.30.440
4m4922YL-lactate dehydrogenase A chain1.1.1.270.440
4tuvCPZCytochrome P450 1191.140.440