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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ea1GPGRibonuclease I3.1.27.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ea1GPGRibonuclease I3.1.27.61.000
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.512
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.499
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.499
4kwhNAPReductase homolog/0.499
4xg1LLPDiaminopimelate decarboxylase/0.498
1bsvNDPGDP-L-fucose synthase/0.496
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.496
2ejzSAHDiphthine synthase/0.494
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.494
4kxjP34Nucleoprotein/0.494
5iu4ZMAAdenosine receptor A2a/0.493
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.492
1dhrNADDihydropteridine reductase1.5.1.340.491
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.490
1fxsNAPGDP-L-fucose synthase/0.489
4mv8ACPBiotin carboxylase6.3.4.140.489
4bb3KKAIsopenicillin N synthase1.21.3.10.488
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.487
3zkyWT4Isopenicillin N synthase1.21.3.10.487
1hfqMOTDihydrofolate reductase1.5.1.30.486
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.486
3h06VBPGlutamate receptor 2/0.486
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.485
2yk2YJXHeat shock protein HSP 90-alpha/0.485
2fznFADBifunctional protein PutA1.5.5.20.484
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.484
4gdeFDAUDP-galactopyranose mutase/0.484
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.484
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.483
3q3cNADNAD-dependent L-serine dehydrogenase/0.483
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.482
1hb3SCVIsopenicillin N synthase1.21.3.10.482
1bozPRDDihydrofolate reductase1.5.1.30.481
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.481
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.480
5iubCLRAdenosine receptor A2a/0.480
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.479
2iviACWIsopenicillin N synthase1.21.3.10.479
3qakUKAAdenosine receptor A2a/0.479
1vyrFMNPentaerythritol tetranitrate reductase/0.478
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.478
4ocvANPAminoglycoside phosphotransferase/0.478
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.477
3gwfFADCyclohexanone monooxygenase/0.477
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.477
1s7lCOAAcetyl transferase/0.476
2z2w770Wee1-like protein kinase2.7.10.20.476
3p62FMNPentaerythritol tetranitrate reductase/0.476
3w78CBDFMN-dependent NADH-azoreductase/0.476
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.475
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.475
1uyePU9Heat shock protein HSP 90-alpha/0.475
3nhyA7BRibosyldihydronicotinamide dehydrogenase [quinone]/0.475
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
1pr9NAPL-xylulose reductase1.1.1.100.474
1bk0ACVIsopenicillin N synthase1.21.3.10.473
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.473
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
2wo7ASVIsopenicillin N synthase1.21.3.10.473
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.473
3hz137DHeat shock protein HSP 90-alpha/0.473
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.473
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.473
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.473
1hb1OCVIsopenicillin N synthase1.21.3.10.472
1oc1ASVIsopenicillin N synthase1.21.3.10.472
1uy7PU4Heat shock protein HSP 90-alpha/0.472
2y60M8FIsopenicillin N synthase1.21.3.10.472
3hz5Z64Heat shock protein HSP 90-alpha/0.472
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.472
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.472
2yejXQKHeat shock protein HSP 90-alpha/0.471
2zb8IMNProstaglandin reductase 21.3.1.480.471
3q5pTACMultidrug-efflux transporter 1 regulator/0.471
1x8lOXRRetinol dehydratase/0.470
2qboCAMCamphor 5-monooxygenase1.14.15.10.470
2x7hPFNProstaglandin reductase 310.470
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.470
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.470
3pqbVGPPutative oxidoreductase/0.470
4dshFDAUncharacterized protein/0.470
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.469
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
2y5s78HDihydropteroate synthase/0.469
3uklFADUDP-galactopyranose mutase/0.469
4a83DXCMajor pollen allergen Bet v 1-A/0.469
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.469
4xivADPChemotaxis protein CheA2.7.13.30.469
1h50FMNPentaerythritol tetranitrate reductase/0.468
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.468
1x8b824Wee1-like protein kinase2.7.10.20.468
2q4wFADCytokinin dehydrogenase 71.5.99.120.468
3lfeZ84Mitogen-activated protein kinase 14/0.468
3q44D50M1 family aminopeptidase3.4.110.468
4plpNADHomospermidine synthase2.5.1.440.468
2pksG44Prothrombin3.4.21.50.467
3l5bBDOBeta-secretase 13.4.23.460.467
4bfuZVUPantothenate kinase2.7.1.330.467
4dbzNDPPutative ketoacyl reductase1.3.10.467
4l8u9AZSerum albumin/0.467
1bwlFMNNADPH dehydrogenase 11.6.99.10.466
1dirNADDihydropteridine reductase1.5.1.340.466
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.466
1x7hNDPPutative ketoacyl reductase1.3.10.466
2p5uNADUDP-glucose 4-epimerase/0.466
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.466
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.466
3ukkFADUDP-galactopyranose mutase/0.466
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
4b63NAPL-ornithine N(5)-monooxygenase/0.466
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.466
5dp2NAPCurF/0.466
1lf3EH5Plasmepsin-23.4.23.390.465
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
1mmaADPMyosin-2 heavy chain/0.465
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.465
2gjnFMNNitronate monooxygenase1.13.12.160.465
2j9lATPH(+)/Cl(-) exchange transporter 5/0.465
2jb4A14Isopenicillin N synthase1.21.3.10.465
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
3ns2PYVAbscisic acid receptor PYL2/0.465
4enhFVXCholesterol 24-hydroxylase/0.465
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.465
4m9aFDAAcyl-CoA dehydrogenase/0.465
4u7wNDPMxaA/0.465
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.464
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.464
1s3wTQTDihydrofolate reductase1.5.1.30.464
1synF89Thymidylate synthase/0.464
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.464
2vkeTACTetracycline repressor protein class D/0.464
3atzFMNProstaglandin F2a synthase/0.464
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3lpjZ75Beta-secretase 13.4.23.460.464
3uceNDPDehydrogenase/0.464
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.464
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.463
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.463
3d0bSNXHeat shock protein HSP 90-alpha/0.463
3d4bDZDNAD-dependent protein deacetylase/0.463
3nr4PYVAbscisic acid receptor PYL2/0.463
3q5kD1UHeat shock protein 83-1/0.463
3sf6FDAGlutaryl-CoA dehydrogenase/0.463
4dsgFADUncharacterized protein/0.463
4gk3L87Ephrin type-A receptor 32.7.10.10.463
4i6gFADCryptochrome-2/0.463
4rrxLURProstaglandin G/H synthase 21.14.99.10.463
5iua6DXAdenosine receptor A2a/0.463
1e7qNAPGDP-L-fucose synthase/0.462
1lb9DNQGlutamate receptor 2/0.462
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.462
1rx8FOLDihydrofolate reductase1.5.1.30.462
1s3uTQDDihydrofolate reductase1.5.1.30.462
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.462
2xvv9DNSerum albumin/0.462
4fqsLYAThymidylate synthase ThyA/0.462
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1aoeGW3Dihydrofolate reductase1.5.1.30.461
1pq944BOxysterols receptor LXR-beta/0.461
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.461
2wi4ZZ4Heat shock protein HSP 90-alpha/0.461
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.461
4dc0NDPPutative ketoacyl reductase1.3.10.461
4e9aQAPPeptide deformylase/0.461
4gk2L66Ephrin type-A receptor 32.7.10.10.461
4hy6FJ1Heat shock protein HSP 90-alpha/0.461
4i8vBHFCytochrome P450 1A11.14.14.10.461
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.461
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.460
1osvCHCBile acid receptor/0.460
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.460
3p3zP3ZPutative cytochrome P450/0.460
3p67FMNPentaerythritol tetranitrate reductase/0.460
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
5jtbZMAAdenosine receptor A2a/0.460
1fmlRTLRetinol dehydratase/0.459
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
2q9fC3SCholesterol 24-hydroxylase/0.459
2vbpVB1Isopenicillin N synthase1.21.3.10.459
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3ft8MOJHeat shock protein HSP 90-alpha/0.459
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3nmpPYVAbscisic acid receptor PYL2/0.459
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3qwbNDPProbable quinone oxidoreductase1.6.5.50.459
3s1dZIRCytokinin dehydrogenase 11.5.99.120.459
3wtkTH4Acetylcholine-binding protein/0.459
3zdu38RCyclin-dependent kinase-like 32.7.11.220.459
4i1nFOLDihydrofolate reductase1.5.1.30.459
4pkl1GHUncharacterized protein/0.459
1drhNAPDihydrofolate reductase1.5.1.30.458
1h51FMNPentaerythritol tetranitrate reductase/0.458
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2bu9HFVIsopenicillin N synthase1.21.3.10.458
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.458
2w6mOA1Biotin carboxylase6.3.4.140.458
3b9lAZZSerum albumin/0.458
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.458
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4b4vL34Bifunctional protein FolD/0.458
4eqkMGTPolymerase basic protein 2/0.458
4q71FADBifunctional protein PutA/0.458
4xguADPPutative pachytene checkpoint protein 2/0.458
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.458
1mczRMNBenzoylformate decarboxylase4.1.1.70.457
2abbFMNPentaerythritol tetranitrate reductase/0.457
2bxmIMNSerum albumin/0.457
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.457
3o26NDPSalutaridine reductase/0.457
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.457
4r81FMNPredicted NADH dehydrogenase/0.457
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.457
1bdmNAXMalate dehydrogenase/0.456
1ezvUQ6Cytochrome b/0.456
1mp0NADAlcohol dehydrogenase class-31.1.1.10.456
1vbiNADMalate/L-lactate dehydrogenase family protein/0.456
2bxqIMNSerum albumin/0.456
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.456
2xvw9NRSerum albumin/0.456
2y6fM9FIsopenicillin N synthase1.21.3.10.456
2ykiYKIHeat shock protein HSP 90-alpha/0.456
3cbsR12Cellular retinoic acid-binding protein 2/0.456
4dz5NAPAldo-keto reductase family 1 member C3/0.456
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4kwi1TJReductase homolog/0.456
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
1h63FMNPentaerythritol tetranitrate reductase/0.455
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1n5dNDPCarbonyl reductase [NADPH] 1/0.455
2pg0FADAcyl-CoA dehydrogenase/0.455
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
3fznD7KBenzoylformate decarboxylase4.1.1.70.455
3h4vDVPPteridine reductase 11.5.1.330.455
3hv3R49Mitogen-activated protein kinase 14/0.455
3o6o94MHeat shock protein 83/0.455
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.455
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
4ddrMMVDihydrofolate reductase1.5.1.30.455
4g2fC07Ephrin type-A receptor 32.7.10.10.455
4kgmATPUncharacterized protein/0.455
5fsxADPUncharacterized protein/0.455
1d0lBLGMembrane-bound lytic murein transglycosylase B4.2.2.n10.454
1e2jTHMThymidine kinase/0.454
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.454
1p16GTPmRNA-capping enzyme subunit alpha2.7.7.500.454
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.454
2bf7HBIPteridine reductase 11.5.1.330.454
2qo9ANPEphrin type-A receptor 32.7.10.10.454
2z3uCRRCytochrome P450/0.454
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3f03FMNPentaerythritol tetranitrate reductase/0.454
3fp0FP015-O-acetyltransferase/0.454
3jziJZLBiotin carboxylase6.3.4.140.454
3uqdADPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.454
4cukNAID-lactate dehydrogenase/0.454
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.454
4ure1PSCyclohexanol dehydrogenase/0.454
5fm7ADPRuvB-like helicase/0.454
5g53NECAdenosine receptor A2a/0.454
1y0s331Peroxisome proliferator-activated receptor delta/0.453
1zdwFLVPrenyltransferase/0.453
2dvlFADAcyl-CoA dehydrogenase/0.453
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.453
2npnSAMPutative cobalamin synthesis related protein/0.453
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3ixp834Ecdysone receptor/0.453
3jpuTY4Transcriptional activator protein LasR/0.453
3mnrSD1Heat shock protein HSP 90-alpha/0.453
3nf8CDQGag-Pol polyprotein/0.453
3s5wFADL-ornithine N(5)-monooxygenase/0.453
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.453
4eiyZMAAdenosine receptor A2a/0.453
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.453
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.453
5iu86DZAdenosine receptor A2a/0.453
1c1c612Gag-Pol polyprotein2.7.7.490.452
1gwrESTEstrogen receptor/0.452
1i6xCMPcAMP-activated global transcriptional regulator CRP/0.452
1mjaCOAHistone acetyltransferase ESA1/0.452
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.452
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3d7zGK5Mitogen-activated protein kinase 14/0.452
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3mdmFJZCholesterol 24-hydroxylase/0.452
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.452
3utgFDAUDP-galactopyranose mutase/0.452
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.452
4cdmFO1Deoxyribodipyrimidine photolyase/0.452
4fv7E94Mitogen-activated protein kinase 12.7.11.240.452
4gh5NADShort-chain dehydrogenase/reductase SDR/0.452
4jzr4JREgl nine homolog 1/0.452
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4rquNADAlcohol dehydrogenase class-P/0.452
4rxsTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.452
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.452
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.451
1p0hCOAMycothiol acetyltransferase2.3.1.1890.451
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
2rqfJH3Hemolymph juvenile hormone binding protein/0.451
2xgs44PUncharacterized protein/0.451
3c3xNAPEugenol synthase 11.1.1.3180.451
3lanKBTGag-Pol polyprotein2.7.7.490.451
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.451
3vjoANPEpidermal growth factor receptor2.7.10.10.451
4an4DUDPutative glycosyl transferase/0.451
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4fhd0TTSpore photoproduct lyase/0.451
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4orkGDPBifunctional AAC/APH2.3.10.451
4u8kFDAUDP-galactopyranose mutase/0.451
1dhiMTXDihydrofolate reductase1.5.1.30.450
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1kvkATPMevalonate kinase2.7.1.360.450
1swtBTNStreptavidin/0.450
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.450
2ykbYKBHeat shock protein HSP 90-alpha/0.450
3cgcCOACoenzyme A disulfide reductase/0.450
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.450
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.450
3ukkFDAUDP-galactopyranose mutase/0.450
3vt9YI4Vitamin D3 receptor/0.450
4b4w9L9Bifunctional protein FolD/0.450
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.450
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4hs4FMNChromate reductase/0.450
4j7hTRHPCZA361.3/0.450
4k5o1OTM1 family aminopeptidase3.4.110.450
4u0mGTPCyclic GMP-AMP synthase/0.450
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
5bt42LOBromodomain-containing protein 4/0.450
3emlZMAAdenosine receptor A2a/0.450
1cjkFOKAdenylate cyclase type 2/0.449
1cjkFOKAdenylate cyclase type 5/0.449
1dr4HBIDihydrofolate reductase1.5.1.30.449
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.449
1ndzFR5Adenosine deaminase3.5.4.40.449
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2c29NAPDihydroflavonol 4-reductase/0.449
2dr3ADPUPF0273 protein PH0284/0.449
2g8yNADHydroxycarboxylate dehydrogenase B/0.449
2o7pNAPRiboflavin biosynthesis protein RibD/0.449
2ofv242Tyrosine-protein kinase Lck2.7.10.20.449
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.449
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
3dgeADPSensor histidine kinase/0.449
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3hk1B64Fatty acid-binding protein, adipocyte/0.449
3pd5TSBThreonine--tRNA ligase6.1.1.30.449
3t3q9PLCytochrome P450 2A61.14.130.449
3to3ATPPetrobactin biosynthesis protein AsbB/0.449
4ia3BIVVitamin D3 receptor A/0.449
4l4xNDPAmphI/0.449
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.449
4v12POGMaoC like domain protein/0.449
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.449
1f20FADNitric oxide synthase, brain1.14.13.390.448
1h74ADPHomoserine kinase2.7.1.390.448
1jpaANPEphrin type-B receptor 22.7.10.10.448
1obnASVIsopenicillin N synthase1.21.3.10.448
1qrpHH0Pepsin A-43.4.23.10.448
1snyNAPLD36273p/0.448
1vkgCRIHistone deacetylase 83.5.1.980.448
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1yhjR6CPyridoxal kinase2.7.1.350.448
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.448
2qmzLDPRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
2ylrNAPPhenylacetone monooxygenase1.14.13.920.448
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3kjm245Cytokinin dehydrogenase 11.5.99.120.448
3lqfNADGalactitol dehydrogenase/0.448
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
4d03NAPPhenylacetone monooxygenase1.14.13.920.448
4n3l2FNProthrombin3.4.21.50.448
4r20AERCytochrome P450 family 17 polypeptide 2/0.448
4u8oFDAUDP-galactopyranose mutase/0.448
4z24FADPutative GMC-type oxidoreductase R13510.448
5iqfGDPBifunctional AAC/APH2.3.10.448
4mqt2CUMuscarinic acetylcholine receptor M2/0.448
1culFOKAdenylate cyclase type 2/0.447
1culFOKAdenylate cyclase type 5/0.447
1ia4TQ6Dihydrofolate reductase1.5.1.30.447
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.447
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.447
2fzmFADBifunctional protein PutA1.5.5.20.447
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.447
2io6330Wee1-like protein kinase2.7.10.20.447
2j4kU5PUridylate kinase2.7.4.220.447
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
2vn0TDZCytochrome P450 2C8/0.447
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.447
2zshGA3Gibberellin receptor GID1A30.447
3aezGDPPantothenate kinase2.7.1.330.447
3c16FOKAdenylate cyclase type 2/0.447
3c16FOKAdenylate cyclase type 5/0.447
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3gkjHC3Niemann-Pick C1 protein/0.447
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.447
3kpkFADSulfide-quinone reductase/0.447
3lu8IQXSerum albumin/0.447
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.447
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.290.447
4h9506UDihydrofolate reductase1.5.1.30.447
4ixd1HVIntegrin alpha-L/0.447
4nh82LCHeat shock protein HSP 90-alpha/0.447
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.447
4yagNAIC alpha-dehydrogenase/0.447
5a3bAPRSIR2 family protein/0.447
5fd8A5APutative carboxypeptidase yocD/0.447
1bwsNDPGDP-L-fucose synthase/0.446
1fwkADPHomoserine kinase2.7.1.390.446
1gcoNADGlucose 1-dehydrogenase1.1.1.470.446
1mvtDTMDihydrofolate reductase1.5.1.30.446
1qorNDPQuinone oxidoreductase 1/0.446
1s7gNADNAD-dependent protein deacylase 2/0.446
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1u4dDBQActivated CDC42 kinase 1/0.446
2ekaSAHDiphthine synthase/0.446
2hl0A3SThreonine--tRNA ligase6.1.1.30.446
2v58LZJBiotin carboxylase6.3.4.140.446
2wu4HBPAcetylcholinesterase3.1.1.70.446
2x0rNADMalate dehydrogenase/0.446
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.446
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.446
3a1l2CCCytochrome P450/0.446
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.446
3h3t16HCollagen type IV alpha-3-binding protein/0.446
3is9AC7Gag-Pol polyprotein2.7.7.490.446
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.446
3uleC69Actin-related protein 3/0.446
3w8dNAD3-hydroxybutyrate dehydrogenase/0.446
3wbbNAPMeso-diaminopimelate D-dehydrogenase/0.446
4bj9UHBTankyrase-22.4.2.300.446
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.446
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.446
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.446
5f54TMPSingle-stranded-DNA-specific exonuclease/0.446
5kf8ACOPredicted acetyltransferase/0.446
5k2bZMAAdenosine receptor A2a/0.446
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1m78NDPDihydrofolate reductase1.5.1.30.445
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.445
1uyhPU0Heat shock protein HSP 90-alpha/0.445
2c12FADNitroalkane oxidase1.7.3.10.445
2fzwNADAlcohol dehydrogenase class-31.1.1.10.445
2gqfFADUncharacterized protein HI_0933/0.445
2hl1A3SThreonine--tRNA ligase6.1.1.30.445
2nq8ZIDEnoyl-ACP reductase/0.445
2ojg19AMitogen-activated protein kinase 12.7.11.240.445
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.445
2r0pK2CPutative FAD-monooxygenase/0.445
2w6oOA3Biotin carboxylase6.3.4.140.445
3bi6396Wee1-like protein kinase2.7.10.20.445
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3bw4FMNPutative 2-nitropropane dioxygenase/0.445
3clrFADElectron transfer flavoprotein subunit alpha/0.445
3gfbNADL-threonine 3-dehydrogenase/0.445
3iaeD7KBenzaldehyde lyase/0.445
3jv7NADSecondary alcohol dehydrogenase/0.445
3o0iP54Heat shock protein HSP 90-alpha/0.445
3owj1ELCasein kinase II subunit alpha2.7.11.10.445
3pd2A3SThreonine--tRNA ligase6.1.1.30.445
3pd3A3TThreonine--tRNA ligase6.1.1.30.445
3w5uFADFerredoxin/0.445
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.445
4kfj1R0Dihydrofolate reductase1.5.1.30.445
4ryvZEAProtein LlR18A/0.445
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.444
1e2nRCAThymidine kinase/0.444
1jomFFODihydrofolate reductase1.5.1.30.444
1tilATPAnti-sigma F factor/0.444
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.444
1uykPUXHeat shock protein HSP 90-alpha/0.444
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.444
2bd0NAPSepiapterin reductase/0.444
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.444
2tpsTPSThiamine-phosphate synthase/0.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
2yeiXQIHeat shock protein HSP 90-alpha/0.444
3h3qH13Collagen type IV alpha-3-binding protein/0.444
3lfzADPUncharacterized protein MJ1225/0.444
3nx4NAPPutative oxidoreductase/0.444
3uthFDAUDP-galactopyranose mutase/0.444
4a39GEMUncharacterized protein/0.444
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.444
4gqiM49Ribosyldihydronicotinamide dehydrogenase [quinone]/0.444
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4u8pFDAUDP-galactopyranose mutase/0.444
8catNDPCatalase1.11.1.60.444
1ae1NAPTropinone reductase 1/0.443
1c7oPPGHemolysin/0.443
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.443
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.443
1pd9CO4Dihydrofolate reductase1.5.1.30.443
2b7aIZATyrosine-protein kinase JAK2/0.443
2f02ATPTagatose-6-phosphate kinase/0.443
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.443
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2po7CHDFerrochelatase, mitochondrial4.99.1.10.443
2vzzSCAPutative succinyl-CoA transferase Rv0802c2.8.30.443
2w71L23Biotin carboxylase6.3.4.140.443
2xltNA0Putative flavin-containing monooxygenase/0.443
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.443
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
3kpzZNEVitamin D3 receptor/0.443
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3mdvCL6Cholesterol 24-hydroxylase/0.443
3nxoD2BDihydrofolate reductase1.5.1.30.443
3tneRITCandidapepsin-13.4.23.240.443
3v94WYQPhosphodiesterase/0.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.443
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.443
4h1e10JBeta-secretase 13.4.23.460.443
4h3i10VBeta-secretase 13.4.23.460.443
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.443
4y0kNAPAntE/0.443
5k2dZMAAdenosine receptor A2a/0.443
3sn6P0GBeta-2 adrenergic receptor/0.443
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.442
1gveNAPAflatoxin B1 aldehyde reductase member 310.442
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.442
1tysDHFThymidylate synthase/0.442
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.442
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.442
2ag1TPPBenzaldehyde lyase/0.442
2c27ACOMycothiol acetyltransferase2.3.1.1890.442
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.442
2gjlFMNNitronate monooxygenase1.13.12.160.442
2gs7ANPEpidermal growth factor receptor2.7.10.10.442
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.442
2ogiGDPUncharacterized protein/0.442
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.442
2v3wTPPBenzoylformate decarboxylase4.1.1.70.442
2v59LZKBiotin carboxylase6.3.4.140.442
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
2xveFADPutative flavin-containing monooxygenase/0.442
2y05NAPProstaglandin reductase 1/0.442
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3ix4TX1Transcriptional activator protein LasR/0.442
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.442
3tqhNDPQuinone oxidoreductase/0.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
4aosFADSteroid monooxygenase/0.442
4g1z0VPVitamin D3 receptor A/0.442
4gevCB3Thymidylate synthase/0.442
4gg50J3Hepatocyte growth factor receptor2.7.10.10.442
4gt8ADPSensor protein VraS2.7.13.30.442
4kbyC2EStimulator of interferon genes protein/0.442
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.442
5a4vQUEGlutathione S-transferase F22.5.1.180.442
1blzACVIsopenicillin N synthase1.21.3.10.441
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.441
1d3pBT3Prothrombin3.4.21.50.441
1hdrNADDihydropteridine reductase1.5.1.340.441
1i59ADPChemotaxis protein CheA2.7.13.30.441
1lf2R37Plasmepsin-23.4.23.390.441
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.441
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.441
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.441
2emuSAHDiphthine synthase/0.441
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.441
2w3wVG9Dihydrofolate reductase/0.441
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.441
3c35KAIGlutamate receptor ionotropic, kainate 1/0.441
3hy7097A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.441
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.441
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4bqg50QHeat shock protein HSP 90-alpha/0.441
4irnFADAnaB/0.441
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.441
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.441
4rww2BALmo2692 protein/0.441
5dbfNDPIridoid synthase1.3.1.990.441
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.441
1bim0QBRenin3.4.23.150.440
1bv9XV6Gag-Pol polyprotein3.4.23.160.440
1f4gTP4Thymidylate synthase/0.440
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.440
1nceCB3Thymidylate synthase/0.440
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.440
1ozpACOMycothiol acetyltransferase2.3.1.1890.440
1qiqACCIsopenicillin N synthase1.21.3.10.440
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.440
1s1rNAPAldo-keto reductase family 1 member C3/0.440
1u3cFADCryptochrome-1/0.440
1xddAAYIntegrin alpha-L/0.440
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2e77FMNLactate oxidase/0.440
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.440
2izfBTNStreptavidin/0.440
2ohhFMNType A flavoprotein FprA10.440
2qg2A91Heat shock protein HSP 90-alpha/0.440
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.440
2v2vV124-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
2ydvNECAdenosine receptor A2a/0.440
3a0tADPSensor histidine kinase/0.440
3adaNADSubunit alpha of sarocosine oxidase/0.440
3arvSAUChitinase A/0.440
3e92G6AMitogen-activated protein kinase 14/0.440
3elySAHMethyltransferase/0.440
3i6iNDPPutative leucoanthocyanidin reductase 1/0.440
3nbvANPKetohexokinase/0.440
3nhjA2ZRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3t8vBTJM1 family aminopeptidase3.4.110.440
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
3wleNAD(R)-specific carbonyl reductase/0.440
3znqSS8D-amino-acid oxidase1.4.3.30.440
3zuyTCHTransporter/0.440
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.440
4b2gV1NUncharacterized protein/0.440
4bfsZVSPantothenate kinase2.7.1.330.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.440
4gl4NAIAlcohol dehydrogenase class-3/0.440
4ktl1CQCytochrome P450/0.440
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.440
4u8nFDAUDP-galactopyranose mutase/0.440
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.440