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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2e9zUTPGenome polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2e9zUTPGenome polyprotein/1.000
3n6mGTPGenome polyprotein/0.526
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.474
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.462
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.462
2itwITQEpidermal growth factor receptor2.7.10.10.452
1u3dFADCryptochrome-1/0.445
4jr3KJREpidermal growth factor receptor2.7.10.10.444
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.444
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.442
4hgt15GCasein kinase I isoform delta2.7.11.10.440