sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2e8q | SAH | Diphthine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2e8q | SAH | Diphthine synthase | / | 1.000 | |
| 2en5 | SAH | Diphthine synthase | / | 0.851 | |
| 2dxv | SAH | Diphthine synthase | / | 0.830 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.830 | |
| 2dxw | SAH | Diphthine synthase | / | 0.826 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.822 | |
| 2e8s | SAH | Diphthine synthase | / | 0.820 | |
| 2pcm | SAH | Diphthine synthase | / | 0.818 | |
| 2emr | SAH | Diphthine synthase | / | 0.804 | |
| 2dsg | SAH | Diphthine synthase | / | 0.802 | |
| 2el0 | SAH | Diphthine synthase | / | 0.800 | |
| 2hux | SAH | Diphthine synthase | / | 0.793 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.786 | |
| 2emu | SAH | Diphthine synthase | / | 0.783 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.779 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.779 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.776 | |
| 2egl | SAH | Diphthine synthase | / | 0.773 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.772 | |
| 2e16 | SAH | Diphthine synthase | / | 0.761 | |
| 2eni | SAH | Diphthine synthase | / | 0.758 | |
| 1wng | SAH | Diphthine synthase | / | 0.756 | |
| 2pch | SAH | Diphthine synthase | / | 0.750 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.749 | |
| 2ejk | SAH | Diphthine synthase | / | 0.720 | |
| 2pca | SAH | Diphthine synthase | / | 0.719 | |
| 2p6d | SAH | Diphthine synthase | / | 0.717 | |
| 2eld | SAH | Diphthine synthase | / | 0.716 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.715 | |
| 2e4n | SAH | Diphthine synthase | / | 0.713 | |
| 2ehl | SAH | Diphthine synthase | / | 0.699 | |
| 2el3 | SAH | Diphthine synthase | / | 0.698 | |
| 2p6k | SAH | Diphthine synthase | / | 0.697 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.691 | |
| 2dek | SAH | Diphthine synthase | / | 0.689 | |
| 2eka | SAH | Diphthine synthase | / | 0.684 | |
| 2pcg | SAH | Diphthine synthase | / | 0.682 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.681 | |
| 2dxx | SAH | Diphthine synthase | / | 0.678 | |
| 2p9d | SAH | Diphthine synthase | / | 0.678 | |
| 2p2x | SAH | Diphthine synthase | / | 0.676 | |
| 2owv | SAH | Diphthine synthase | / | 0.669 | |
| 2e7r | SAH | Diphthine synthase | / | 0.666 | |
| 2e8h | SAH | Diphthine synthase | / | 0.663 | |
| 1vce | SAH | Diphthine synthase | / | 0.662 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.662 | |
| 2egs | SAH | Diphthine synthase | / | 0.661 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.657 | |
| 2p6l | SAH | Diphthine synthase | / | 0.655 | |
| 2p5c | SAH | Diphthine synthase | / | 0.654 | |
| 2owg | SAH | Diphthine synthase | / | 0.651 | |
| 2ejj | SAH | Diphthine synthase | / | 0.649 | |
| 2pci | SAH | Diphthine synthase | / | 0.649 | |
| 2huv | SAH | Diphthine synthase | / | 0.648 | |
| 2owk | SAH | Diphthine synthase | / | 0.638 | |
| 2e8r | SAH | Diphthine synthase | / | 0.635 | |
| 2p5f | SAH | Diphthine synthase | / | 0.631 | |
| 2z6r | SAH | Diphthine synthase | / | 0.631 | |
| 2dsi | SAH | Diphthine synthase | / | 0.629 | |
| 2egb | SAH | Diphthine synthase | / | 0.628 | |
| 2ele | SAH | Diphthine synthase | / | 0.628 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.625 | |
| 2huq | SAH | Diphthine synthase | / | 0.617 | |
| 2e07 | SAH | Diphthine synthase | / | 0.611 | |
| 2p6i | SAH | Diphthine synthase | / | 0.611 | |
| 2e17 | SAH | Diphthine synthase | / | 0.609 | |
| 2eeq | SAH | Diphthine synthase | / | 0.607 | |
| 2pck | SAH | Diphthine synthase | / | 0.602 | |
| 2dsh | SAH | Diphthine synthase | / | 0.601 | |
| 2owu | SAH | Diphthine synthase | / | 0.592 | |
| 2owf | SAH | Diphthine synthase | / | 0.591 | |
| 2hut | SAH | Diphthine synthase | / | 0.583 | |
| 2e08 | SAH | Diphthine synthase | / | 0.582 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.575 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.561 | |
| 2ejz | SAH | Diphthine synthase | / | 0.550 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.533 | |
| 2e15 | SAH | Diphthine synthase | / | 0.511 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.493 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.492 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.485 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.483 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.481 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.478 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.477 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.475 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.475 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.475 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.475 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.474 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.473 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.473 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.473 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.473 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.471 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.470 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.469 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4kb9 | G79 | Protease | / | 0.469 | |
| 4xr9 | NAD | CalS8 | / | 0.469 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.468 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.468 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.467 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.465 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.465 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.465 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.464 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.464 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.464 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.463 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.463 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.463 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.462 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.462 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.461 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.461 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.461 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.461 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1h8h | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.460 | |
| 1h8h | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.460 | |
| 3a3g | DLZ | Lumazine protein | / | 0.460 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.459 | |
| 2p3b | 3TL | V-1 protease | / | 0.459 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.459 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.458 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.458 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.458 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.458 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.458 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.457 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.457 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.457 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.457 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.457 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.457 | |
| 1e1q | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.456 | |
| 1e1q | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.456 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.456 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.456 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.456 | |
| 4lut | DCS | Alanine racemase | / | 0.456 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.455 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.455 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.455 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.454 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.454 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.454 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.454 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.453 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.453 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.453 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.453 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.452 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.452 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.452 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.452 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.452 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.452 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.452 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.451 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.451 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.451 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.451 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.451 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.450 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.450 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.450 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.450 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.450 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.449 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.449 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.449 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.449 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.449 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.449 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.449 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.448 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.448 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.448 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.448 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.447 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.447 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1 | / | 0.447 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1-binding protein 1 | / | 0.447 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.447 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.447 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.446 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.446 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.446 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.446 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.446 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.445 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.445 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 2f81 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.445 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.445 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.445 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.445 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.445 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.444 | |
| 1zio | AP5 | Adenylate kinase | / | 0.444 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.444 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.444 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.444 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.443 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4h30 | 0ZD | Macrophage metalloelastase | 3.4.24.65 | 0.443 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.443 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.442 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.442 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.442 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.442 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.441 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.441 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.441 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.441 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.441 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.441 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.441 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.440 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.440 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.440 | |
| 3v2u | ATP | Protein GAL3 | / | 0.440 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.440 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.440 |