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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2e8hSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2e8hSAHDiphthine synthase/1.000
2dekSAHDiphthine synthase/0.833
2p6lSAHDiphthine synthase/0.807
2owvSAHDiphthine synthase/0.784
2dsgSAHDiphthine synthase/0.781
2eglSAHDiphthine synthase/0.761
2eniSAHDiphthine synthase/0.750
2dv7SAHDiphthine synthase/0.745
2eeqSAHDiphthine synthase/0.744
2e08SAHDiphthine synthase/0.738
2e16SAHDiphthine synthase/0.738
2ejjSAHDiphthine synthase/0.726
2owuSAHDiphthine synthase/0.726
2p6iSAHDiphthine synthase/0.724
2emuSAHDiphthine synthase/0.723
2dv4SAHDiphthine synthase/0.720
2egbSAHDiphthine synthase/0.705
2emrSAHDiphthine synthase/0.704
2dxvSAHDiphthine synthase/0.702
2eh5SAHDiphthine synthase/0.701
2ejkSAHDiphthine synthase/0.700
1wngSAHDiphthine synthase/0.693
2dxwSAHDiphthine synthase/0.690
2ek2SAHDiphthine synthase/0.681
2dsiSAHDiphthine synthase/0.680
2ehlSAHDiphthine synthase/0.677
2el0SAHDiphthine synthase/0.676
2e07SAHDiphthine synthase/0.675
2e8sSAHDiphthine synthase/0.675
2egsSAHDiphthine synthase/0.675
2huxSAHDiphthine synthase/0.674
1vceSAHDiphthine synthase/0.672
2e15SAHDiphthine synthase/0.669
2e17SAHDiphthine synthase/0.669
2en5SAHDiphthine synthase/0.668
2pciSAHDiphthine synthase/0.667
2p6kSAHDiphthine synthase/0.666
2e8qSAHDiphthine synthase/0.663
2hr8SAHDiphthine synthase/0.662
2pb4SAHDiphthine synthase/0.661
2ek7SAHDiphthine synthase/0.658
2pb6SAHDiphthine synthase/0.657
2pckSAHDiphthine synthase/0.657
2dv3SAHDiphthine synthase/0.656
2ed5SAHDiphthine synthase/0.656
2pcmSAHDiphthine synthase/0.656
2z6rSAHDiphthine synthase/0.655
2hutSAHDiphthine synthase/0.653
2p6dSAHDiphthine synthase/0.649
2p5cSAHDiphthine synthase/0.647
2dshSAHDiphthine synthase/0.646
2e7rSAHDiphthine synthase/0.646
2eh2SAHDiphthine synthase/0.644
2ed3SAHDiphthine synthase/0.640
2ek3SAHDiphthine synthase/0.640
2eldSAHDiphthine synthase/0.632
2dxxSAHDiphthine synthase/0.630
2eh4SAHDiphthine synthase/0.626
2pb5SAHDiphthine synthase/0.626
2ekaSAHDiphthine synthase/0.624
2owkSAHDiphthine synthase/0.623
2pcgSAHDiphthine synthase/0.621
2pchSAHDiphthine synthase/0.621
2dv5SAHDiphthine synthase/0.619
2e4nSAHDiphthine synthase/0.614
2eleSAHDiphthine synthase/0.609
2e8rSAHDiphthine synthase/0.607
2huqSAHDiphthine synthase/0.604
2p2xSAHDiphthine synthase/0.604
2p5fSAHDiphthine synthase/0.603
2el3SAHDiphthine synthase/0.593
2p9dSAHDiphthine synthase/0.593
2owfSAHDiphthine synthase/0.589
2ejzSAHDiphthine synthase/0.586
2ek4SAHDiphthine synthase/0.576
2huvSAHDiphthine synthase/0.575
2pcaSAHDiphthine synthase/0.574
2owgSAHDiphthine synthase/0.556
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.524
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.506
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.505
2ifaFMNUncharacterized protein/0.502
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.501
4g7gVFVLanosterol 14-alpha-demethylase/0.498
1x1dSAHC-20 methyltransferase/0.497
1zeoC01Peroxisome proliferator-activated receptor gamma/0.497
2gjlFMNNitronate monooxygenase1.13.12.160.497
2xhd7T9Glutamate receptor 2/0.497
1xe55FEPlasmepsin-23.4.23.390.494
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.494
2y3sTIRTamL/0.494
1g1aNADdTDP-glucose 4,6-dehydratase/0.492
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.492
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.491
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.489
4ipw1G7Mycocyclosin synthase1.14.21.90.487
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.487
1nhhANPDNA mismatch repair protein MutL/0.485
3lzs017Gag-Pol polyprotein3.4.23.160.485
1x1bSAHC-20 methyltransferase/0.484
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.484
4m83ERYOleandomycin glycosyltransferase2.4.10.484
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.483
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.483
1dirNADDihydropteridine reductase1.5.1.340.482
3gw9VNILanosterol 14-alpha-demethylase/0.482
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.482
1x1aSAMC-20 methyltransferase/0.481
1lbcCYZGlutamate receptor 2/0.480
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.480
1hdrNADDihydropteridine reductase1.5.1.340.479
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
1x1cSAHC-20 methyltransferase/0.478
2qbuSAHPrecorrin-2 methyltransferase/0.478
2rlcCHDCholoylglycine hydrolase3.5.1.240.478
1nzdUPGDNA beta-glucosyltransferase/0.477
3iltTRUGlutamate receptor 2/0.477
3vqsJT1Genome polyprotein/0.477
3zh8C58Protein kinase C iota type2.7.11.130.476
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.476
1t88CAMCamphor 5-monooxygenase1.14.15.10.475
2rcyNAPPyrroline-5-carboxylate reductase/0.475
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.475
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.475
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.475
1f20FADNitric oxide synthase, brain1.14.13.390.474
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.474
3ijoB4DGlutamate receptor 2/0.474
4kgnSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.474
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.473
2q5g1FAPeroxisome proliferator-activated receptor delta/0.473
1bwsNDPGDP-L-fucose synthase/0.472
1nooCAHCamphor 5-monooxygenase1.14.15.10.472
1tqf32PBeta-secretase 13.4.23.460.472
3ig6438Urokinase-type plasminogen activator3.4.21.730.472
4dpuAGSMevalonate diphosphate decarboxylase/0.472
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.471
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.471
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.471
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.471
5fm7ADPRuvB-like helicase/0.471
3gqvNAPEnoyl reductase LovC10.470
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.470
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.470
4nbwNADShort-chain dehydrogenase/reductase SDR/0.470
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.469
3bc3OPTCathepsin L13.4.22.150.469
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.469
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.469
1beuIPLTryptophan synthase alpha chain/0.468
1f8wFADNADH peroxidase1.11.1.10.468
1xe65FPPlasmepsin-23.4.23.390.468
2iqgF2IBeta-secretase 13.4.23.460.468
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.468
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.468
4r21STRCytochrome P450 family 17 polypeptide 2/0.468
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.467
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.467
1zioAP5Adenylate kinase/0.467
2c29NAPDihydroflavonol 4-reductase/0.467
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
3raiX85Cyclin-dependent kinase 22.7.11.220.467
1tehNADAlcohol dehydrogenase class-31.1.1.10.466
2q4bNAPUncharacterized protein At5g02240/0.466
3lqfNADGalactitol dehydrogenase/0.466
3ox4NADAlcohol dehydrogenase 21.1.1.10.466
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.466
3vt7VDXVitamin D3 receptor/0.466
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1k7fIAVTryptophan synthase alpha chain/0.465
1v9aSAHUncharacterized protein/0.465
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3p62FMNPentaerythritol tetranitrate reductase/0.465
3sf6FDAGlutaryl-CoA dehydrogenase/0.465
3toxNAPPutative oxidoreductase/0.465
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
4yxm2BADNA integrity scanning protein DisA/0.465
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.464
2a94AP0L-lactate dehydrogenase1.1.1.270.464
2dvlFADAcyl-CoA dehydrogenase/0.464
2g1r3IGRenin3.4.23.150.464
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.464
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.464
4djy0KRBeta-secretase 13.4.23.460.464
4g3jVNTLanosterol 14-alpha-demethylase/0.464
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.464
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.464
4q73FADBifunctional protein PutA/0.464
4u0mATPCyclic GMP-AMP synthase/0.464
4wudANPDNA gyrase subunit B/0.464
2he5NDPAldo-keto reductase family 1 member C211.1.10.463
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.463
2zvcSAHPrecorrin-3 C17-methyltransferase/0.463
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3hyoADPPyridoxal kinase/0.463
3uylTYDProbable NDP-rhamnosyltransferase/0.463
3wv9FEGHmd co-occurring protein HcgE/0.463
4a83DXCMajor pollen allergen Bet v 1-A/0.463
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.463
4xguADPPutative pachytene checkpoint protein 2/0.463
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.462
1kfbIGPTryptophan synthase alpha chain/0.462
1yb5NAPQuinone oxidoreductase1.6.5.50.462
2xlrFADPutative flavin-containing monooxygenase/0.462
3c1y2BADNA integrity scanning protein DisA/0.462
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.462
1hncGDNGlutathione S-transferase Mu 22.5.1.180.461
1ma0NADAlcohol dehydrogenase class-31.1.1.10.461
1me6IVSPlasmepsin-23.4.23.390.461
1qrpHH0Pepsin A-43.4.23.10.461
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.461
2vnaNAPProstaglandin reductase 21.3.1.480.461
3em3478Gag-Pol polyprotein3.4.23.160.461
3vdqNAD3-hydroxybutyrate dehydrogenase/0.461
4a8v2ANMajor pollen allergen Bet v 1-J/0.461
4wucANPDNA gyrase subunit B/0.461
4yqfGDPSeptin-9/0.461
5d3qGDPDynamin-13.6.5.50.461
5hwsNAP2-dehydropantoate 2-reductase/0.461
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.460
1cf3FADGlucose oxidase1.1.3.40.460
1h8hATPATP synthase subunit alpha, mitochondrial/0.460
1h8hATPATP synthase subunit beta, mitochondrial3.6.3.140.460
1kp3ATPArgininosuccinate synthase6.3.4.50.460
1pd9CO4Dihydrofolate reductase1.5.1.30.460
2is0I03Beta-secretase 13.4.23.460.460
3f3sNADLambda-crystallin homolog/0.460
3k5c0BIBeta-secretase 13.4.23.460.460
3to6LYS_CMCHistone acetyltransferase ESA1/0.460
4bfzZVZPantothenate kinase2.7.1.330.460
4egbNADdTDP-glucose 4,6-dehydratase/0.460
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1omoNADAlanine dehydrogenase/0.459
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
2ien017Gag-Pol polyprotein3.4.23.160.459
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.459
3b70NAPEnoyl reductase LovC10.459
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.459
3wb2YGPUncharacterized protein MJ0488/0.459
4dptAGSMevalonate diphosphate decarboxylase/0.459
4jxrACOAcetyltransferase/0.459
4oqyNDP(S)-imine reductase/0.459
1geeNADGlucose 1-dehydrogenase1.1.1.470.458
1lf2R37Plasmepsin-23.4.23.390.458
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.458
1phgMYTCamphor 5-monooxygenase1.14.15.10.458
2fznFADBifunctional protein PutA1.5.5.20.458
2iyfERYOleandomycin glycosyltransferase2.4.10.458
2oapANPType II secretion system protein (GspE-2)/0.458
3a3gDLZLumazine protein/0.458
3clrFADElectron transfer flavoprotein subunit alpha/0.458
3pqbVGPPutative oxidoreductase/0.458
3s1dZIRCytokinin dehydrogenase 11.5.99.120.458
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.458
3tneRITCandidapepsin-13.4.23.240.458
4acxS8ZBeta-secretase 13.4.23.460.458
4h3f10OBeta-secretase 13.4.23.460.458
4i1nFOLDihydrofolate reductase1.5.1.30.458
4i8zG08Gag-Pol polyprotein3.4.23.160.458
4qecNAPElxO/0.458
1pjcNADAlanine dehydrogenase/0.457
1udaUFGUDP-glucose 4-epimerase5.1.3.20.457
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.457
2givACOHistone acetyltransferase KAT8/0.457
2wedPP6Penicillopepsin-13.4.23.200.457
2xx91NFGlutamate receptor 2/0.457
3rsv3RSBeta-secretase 13.4.23.460.457
3veu0GOBeta-secretase 13.4.23.460.457
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.457
4b79NADProbable short-chain dehydrogenase/0.457
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.457
4eb7PLPCysteine desulfurase IscS 2/0.457
4ji91M3Tyrosine-protein kinase JAK2/0.457
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.457
5f54TMPSingle-stranded-DNA-specific exonuclease/0.457
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1lf3EH5Plasmepsin-23.4.23.390.456
2znnS44Peroxisome proliferator-activated receptor alpha/0.456
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.456
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3pndFADFAD:protein FMN transferase/0.456
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.456
3u8l09QAcetylcholine-binding protein/0.456
4bfxZVXPantothenate kinase2.7.1.330.456
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
4gl4NAIAlcohol dehydrogenase class-3/0.456
1civNAPMalate dehydrogenase [NADP], chloroplastic1.1.1.820.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1w6hTITPlasmepsin-23.4.23.390.455
1y4lSVRBasic phospholipase A2 homolog 2/0.455
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.455
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.455
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3gwfNAPCyclohexanone monooxygenase/0.455
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.455
3qe2FMNNADPH--cytochrome P450 reductase/0.455
3u9eCOALmo1369 protein/0.455
4blrUTPNTPase P4/0.455
4exg916Beta-secretase 13.4.23.460.455
4fxy0W2Neurolysin, mitochondrial3.4.24.160.455
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.455
4q71FADBifunctional protein PutA/0.455
5dp2NAPCurF/0.455
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.454
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1mj9COAHistone acetyltransferase ESA1/0.454
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.454
3k5fAYHBeta-secretase 13.4.23.460.454
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3orfNADDihydropteridine reductase1.5.1.340.454
3q43D66M1 family aminopeptidase3.4.110.454
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.454
4xr9NADCalS8/0.454
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.454
5irnADPNucleotide binding oligomerization domain containing 2/0.454
1f8fNADBenzyl alcohol dehydrogenase/0.453
1fm4DXCMajor pollen allergen Bet v 1-L/0.453
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.453
1korANPArgininosuccinate synthase/0.453
1t2cNAIL-lactate dehydrogenase1.1.1.270.453
1xddAAYIntegrin alpha-L/0.453
1y0s331Peroxisome proliferator-activated receptor delta/0.453
1yrdCAMCamphor 5-monooxygenase1.14.15.10.453
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2ph835ABeta-secretase 13.4.23.460.453
2x0iNAIMalate dehydrogenase/0.453
2ylzFADPhenylacetone monooxygenase1.14.13.920.453
3ai3NDPNADPH-sorbose reductase/0.453
3e8xNAPBH1520 protein/0.453
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.453
4a862ANMajor pollen allergen Bet v 1-A/0.453
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.453
1bim0QBRenin3.4.23.150.452
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1jqdSAHHistamine N-methyltransferase2.1.1.80.452
1kkq471Peroxisome proliferator-activated receptor alpha/0.452
1nzfUPGDNA beta-glucosyltransferase/0.452
1psa0ZLPepsin A3.4.23.10.452
2c20NADUDP-glucose 4-epimerase/0.452
2fonFADAcyl-coenzyme A oxidase/0.452
2z54AB1Gag-Pol polyprotein3.4.23.160.452
3clsFADElectron transfer flavoprotein subunit alpha/0.452
3d91REMRenin3.4.23.150.452
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.452
3nutSAHPrecorrin-3 methylase/0.452
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.452
4i1iNADMalate dehydrogenase/0.452
1drhNAPDihydrofolate reductase1.5.1.30.451
1g63FMNEpidermin decarboxylase4.1.10.451
2ahrNAPPyrroline-5-carboxylate reductase/0.451
2b53D23Cyclin-dependent kinase 22.7.11.220.451
2bjfDXCCholoylglycine hydrolase3.5.1.240.451
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.451
2gv8NDPThiol-specific monooxygenase1.14.130.451
2hk9NAPShikimate dehydrogenase (NADP(+))/0.451
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.451
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.451
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.451
3p7nFMNLight-activated DNA-binding protein EL222/0.451
3qwbNDPProbable quinone oxidoreductase1.6.5.50.451
3t2zFADSulfide-quinone reductase/0.451
3vt9YI4Vitamin D3 receptor/0.451
4bfuZVUPantothenate kinase2.7.1.330.451
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.451
4yaoFMNNADPH--cytochrome P450 reductase/0.451
1vikBAYGag-Pol polyprotein/0.450
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.450
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.450
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.450
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.450
2nniMTKCytochrome P450 2C8/0.450
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.450
2xvu9DNSerum albumin/0.450
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.450
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.450
3oibFDAPutative acyl-CoA dehydrogenase/0.450
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.450
3rtnRTNBeta-secretase 13.4.23.460.450
3tjzGNPADP-ribosylation factor 1/0.450
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.450
3zoiM2WIsopenicillin N synthase1.21.3.10.450
4b65FADL-ornithine N(5)-monooxygenase/0.450
4frkDWDBeta-secretase 13.4.23.460.450
4h3j10WBeta-secretase 13.4.23.460.450
4wecNADShort chain dehydrogenase/0.450
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
1gcoNADGlucose 1-dehydrogenase1.1.1.470.449
1gqtACPRibokinase/0.449
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.449
1thnADPAnti-sigma F factor/0.449
1xl5190Gag-Pol polyprotein3.4.23.160.449
2ikuLIYRenin3.4.23.150.449
2iviACWIsopenicillin N synthase1.21.3.10.449
2rhgIGPTryptophan synthase alpha chain/0.449
2xyuQ9GEphrin type-A receptor 42.7.10.10.449
3co93MSGenome polyprotein2.7.7.480.449
3djjFADGlutathione reductase, mitochondrial1.8.1.70.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.449
3nxxNDPDihydrofolate reductase1.5.1.30.449
3qt62P0Mevalonate diphosphate decarboxylase/0.449
3zuyTCHTransporter/0.449
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.449
4f5yC2EStimulator of interferon genes protein/0.449
4kb9G79Protease/0.449
4yagNAIC alpha-dehydrogenase/0.449
1bmfANPATP synthase subunit alpha, mitochondrial/0.448
1bmfANPATP synthase subunit beta, mitochondrial3.6.3.140.448
1dhrNADDihydropteridine reductase1.5.1.340.448
1j21ATPArgininosuccinate synthase/0.448
1obnASVIsopenicillin N synthase1.21.3.10.448
1tj2FADBifunctional protein PutA1.5.5.20.448
1vbiNADMalate/L-lactate dehydrogenase family protein/0.448
2pswCOAN-alpha-acetyltransferase 50/0.448
2webPP4Penicillopepsin-13.4.23.200.448
2zbaZBATrichothecene 3-O-acetyltransferase/0.448
3ad9NADSubunit alpha of sarocosine oxidase/0.448
3b2eADPATPase GET3/0.448
3bbrBHYGlutamate receptor 2/0.448
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3dm6757Beta-secretase 13.4.23.460.448
3ggfGVDSerine/threonine-protein kinase 26/0.448
3lpjZ75Beta-secretase 13.4.23.460.448
3slkNDPPolyketide synthase extender module 2/0.448
4dbzNDPPutative ketoacyl reductase1.3.10.448
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.448
4ig01FGGag-Pol polyprotein2.7.7.490.448
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.448
4m4922YL-lactate dehydrogenase A chain1.1.1.270.448
4mv8ACPBiotin carboxylase6.3.4.140.448
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.448
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
1kfcIPLTryptophan synthase alpha chain/0.447
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.447
1qy5NECEndoplasmin/0.447
1tj0FADBifunctional protein PutA1.5.5.20.447
2a87FADThioredoxin reductase1.8.1.90.447
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2iko7IGRenin3.4.23.150.447
2irzI02Beta-secretase 13.4.23.460.447
2p5uNADUDP-glucose 4-epimerase/0.447
2ph6712Beta-secretase 13.4.23.460.447
2v7qATPATP synthase subunit alpha, mitochondrial/0.447
2v7qATPATP synthase subunit beta, mitochondrial3.6.3.140.447
2xfsJ01Uncharacterized protein/0.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
2yj4ATPCopper-transporting ATPase/0.447
3a1nNADNDP-sugar epimerase/0.447
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.447
3phjDHKShikimate dehydrogenase (NADP(+))/0.447
3prsRITEndothiapepsin3.4.23.220.447
3r9uFADThioredoxin reductase/0.447
3tr05GPGuanylate kinase/0.447
4emtC2EStimulator of interferon genes protein/0.447
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.447
4fv7E94Mitogen-activated protein kinase 12.7.11.240.447
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.447
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.447
5c77SAHProtein arginine N-methyltransferase SFM1/0.447
1bwlFMNNADPH dehydrogenase 11.6.99.10.446
1h73ANPHomoserine kinase2.7.1.390.446
1ptjNAPNAD(P) transhydrogenase subunit beta1.6.1.20.446
1qjfACSIsopenicillin N synthase1.21.3.10.446
1qoqIGPTryptophan synthase alpha chain/0.446
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.446
1w0kADPATP synthase subunit alpha, mitochondrial/0.446
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.446
2ebaFADPutative glutaryl-CoA dehydrogenase/0.446
2g8yNADHydroxycarboxylate dehydrogenase B/0.446
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.446
2p3b3TLV-1 PROTEASE protein/0.446
2p3b3TLV-1 protease/0.446
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3br3ETHTH-type transcriptional regulator QacR/0.446
3h06VBPGlutamate receptor 2/0.446
3h2sNDPPutative NADH-flavin reductase/0.446
3kpkFADSulfide-quinone reductase/0.446
3lpkZ76Beta-secretase 13.4.23.460.446
3nmpPYVAbscisic acid receptor PYL2/0.446
3qlrNDPDihydrofolate reductase1.5.1.30.446
3zkyWT4Isopenicillin N synthase1.21.3.10.446
4ap3FADSteroid monooxygenase/0.446
4bftZVTPantothenate kinase2.7.1.330.446
4df2FMNNADPH dehydrogenase/0.446
4enhFVXCholesterol 24-hydroxylase/0.446
4irnFADAnaB/0.446
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.446
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.446
1cdoNADAlcohol dehydrogenase 11.1.1.10.445
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
1j1zATPArgininosuccinate synthase/0.445
1kp2ATPArgininosuccinate synthase6.3.4.50.445
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.445
2w06FRVCyclin-dependent kinase 22.7.11.220.445
2x06NADL-sulfolactate dehydrogenase/0.445
2zvbSAHPrecorrin-3 C17-methyltransferase/0.445
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3duyAFJBeta-secretase 13.4.23.460.445
3f63GTXGlutathione transferase GST1-4/0.445
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.445
3gvhNADMalate dehydrogenase/0.445
3kb1ADPIron-sulfur cluster carrier protein/0.445
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4dc0NDPPutative ketoacyl reductase1.3.10.445
4hy6FJ1Heat shock protein HSP 90-alpha/0.445
4q72FADBifunctional protein PutA/0.445
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.445
1e1qANPATP synthase subunit alpha, mitochondrial/0.444
1e1qANPATP synthase subunit beta, mitochondrial3.6.3.140.444
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.444
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1w4xFADPhenylacetone monooxygenase1.14.13.920.444
2g1y5IGRenin3.4.23.150.444
2vprTDCTetracycline repressor protein class H/0.444
2xfiXFIBeta-secretase 13.4.23.460.444
3b03VNRIsopentenyl-diphosphate delta-isomerase/0.444
3i25MV7Beta-secretase 13.4.23.460.444
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.444
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.444
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.444
3toh079Gag-Pol polyprotein2.7.7.490.444
3vt8YI3Vitamin D3 receptor/0.444
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.444
4j75TYMTryptophan--tRNA ligase/0.444
4lcjNADC-terminal-binding protein 2/0.444
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.444
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.444
5cyoGDPSeptin-9/0.444
1bsvNDPGDP-L-fucose synthase/0.443
1bxoPP7Penicillopepsin-13.4.23.200.443
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.443
1nvmNADAcetaldehyde dehydrogenase1.2.1.100.443
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.443
1u2yGOXPancreatic alpha-amylase/0.443
1xs7MMIBeta-secretase 13.4.23.460.443
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.443
1z1fSTLResveratrol synthase/0.443
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.443
2af3COAPhosphate acetyltransferase2.3.1.80.443
2cftPLPPyridoxal phosphate phosphatase/0.443
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.443
2dftADPShikimate kinase2.7.1.710.443
2eklNADD-3-phosphoglycerate dehydrogenase/0.443
2rqfJH3Hemolymph juvenile hormone binding protein/0.443
2vbdV10Isopenicillin N synthase1.21.3.10.443
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.443
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.443
2y0mACOHistone acetyltransferase KAT8/0.443
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.443
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.443
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
3oev3OEProteasome subunit beta type-53.4.25.10.443
3oev3OEProteasome subunit beta type-63.4.25.10.443
3triNAPPyrroline-5-carboxylate reductase/0.443
3w8eNAD3-hydroxybutyrate dehydrogenase/0.443
3wagTYDGlycosyltransferase/0.443
4ca83ESAngiotensin-converting enzyme3.4.15.10.443
4dx9SER_ALA_VAL_THRIntegrin beta-1/0.443
4dx9SER_ALA_VAL_THRIntegrin beta-1-binding protein 1/0.443
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.443
4fn4NADShort chain dehydrogenase/0.443
4ke11R6Beta-secretase 13.4.23.460.443
4r20AERCytochrome P450 family 17 polypeptide 2/0.443
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.443
6ctsCICCitrate synthase, mitochondrial2.3.3.10.443
1bdlIM1Gag-Pol polyprotein3.4.23.160.442
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.442
1culFOKAdenylate cyclase type 2/0.442
1culFOKAdenylate cyclase type 5/0.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1e3eNAIAlcohol dehydrogenase 41.1.1.10.442
1gaqFADFerredoxin/0.442
1hbvGANGag-Pol polyprotein/0.442
1ja0FMNNADPH--cytochrome P450 reductase/0.442
1mjaCOAHistone acetyltransferase ESA1/0.442
1t87CAMCamphor 5-monooxygenase1.14.15.10.442
1vsoAT1Glutamate receptor ionotropic, kainate 1/0.442
2b8l5HABeta-secretase 13.4.23.460.442
2bf4FMNNADPH--cytochrome P450 reductase/0.442
2g1n1IGRenin3.4.23.150.442
2g1s4IGRenin3.4.23.150.442
2i4qUA4Renin3.4.23.150.442
2wecPP5Penicillopepsin-13.4.23.200.442
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3ik6HCZGlutamate receptor 2/0.442
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.442
3v2uATPProtein GAL3/0.442
3wqmB29Diterpene synthase3.1.7.80.442
4du82P0Mevalonate diphosphate decarboxylase/0.442
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.442
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.442
4prvADPDNA gyrase subunit B/0.442
4pzkSAHPutative tRNA (cytidine(34)-2'-O)-methyltransferase/0.442
4q4kFMNUncharacterized protein/0.442
4wriOKAOkadaic acid binding protein 2-alpha/0.442
5af7FADAcyl-CoA dehydrogenase/0.442
3vw7VPXProteinase-activated receptor 1/0.442
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.441
1g28FMNPHY3/0.441
1g6kNADGlucose 1-dehydrogenase1.1.1.470.441
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.441
1mp0NADAlcohol dehydrogenase class-31.1.1.10.441
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.441
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.441
2g226IGRenin3.4.23.150.441
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.441
2il2LIXRenin3.4.23.150.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
2ou2ACOHistone acetyltransferase KAT5/0.441
2vwhNAPGlucose 1-dehydrogenase/0.441
3hl0NADMaleylacetate reductase/0.441
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.441
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.441
3ohh3HHBeta-secretase 13.4.23.460.441
3phiNDPShikimate dehydrogenase (NADP(+))/0.441
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.441
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.441
3sdkP3NProteasome subunit beta type-53.4.25.10.441
3sdkP3NProteasome subunit beta type-63.4.25.10.441
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.441
3zhyFM61-deoxy-D-xylulose 5-phosphate reductoisomerase/0.441
4ambDUDPutative glycosyl transferase/0.441
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.441
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.441
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4qxq1YEStimulator of interferon genes protein/0.441
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.441
4y3jHICEndothiapepsin3.4.23.220.441
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
5jscFADPutative acyl-CoA dehydrogenase/0.441
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.440
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.440
1mjbACOHistone acetyltransferase ESA1/0.440
1msmJE2Gag-Pol polyprotein3.4.23.160.440
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.440
1xvaSAMGlycine N-methyltransferase2.1.1.200.440
2c12FADNitroalkane oxidase1.7.3.10.440
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.440
2f3eAXQBeta-secretase 13.4.23.460.440
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.440
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2qimZEAClass 10 plant pathogenesis-related protein/0.440
2vkeTACTetracycline repressor protein class D/0.440
2xveFADPutative flavin-containing monooxygenase/0.440
2znq401Peroxisome proliferator-activated receptor delta/0.440
3junAKDPhenazine biosynthesis protein A/B/0.440
3lpiZ74Beta-secretase 13.4.23.460.440
3ogwIMNLactoperoxidase1.11.1.70.440
3pwm017Gag-Pol polyprotein3.4.23.160.440
3qvpFADGlucose oxidase1.1.3.40.440
3w5uFADFerredoxin/0.440
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.440
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.440
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.440
4jlj1NMDeoxycytidine kinase2.7.1.740.440
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.440
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.440
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.440
4lol1YEStimulator of interferon genes protein/0.440
4o8aFADBifunctional protein PutA1.2.1.880.440
4prxADPDNA gyrase subunit B/0.440
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.440
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440