scPDB - Distribution of Binding site Similarity values of 2dv0 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2dv0	ZST	Aldose reductase	1.1.1.21

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2dv0	ZST	Aldose reductase	1.1.1.21	1.000
2hv5	ZST	Aldose reductase	1.1.1.21	0.801
2fz9	ZST	Aldose reductase	1.1.1.21	0.794
2fz8	ZST	Aldose reductase	1.1.1.21	0.683
2pdx	ZST	Aldose reductase	1.1.1.21	0.682
2hvn	ZST	Aldose reductase	1.1.1.21	0.667
3m64	393	Aldose reductase	1.1.1.21	0.662
2ikj	393	Aldose reductase	1.1.1.21	0.657
1t40	ID5	Aldose reductase	1.1.1.21	0.655
2pdm	ZST	Aldose reductase	1.1.1.21	0.651
1z3n	3NA	Aldose reductase	1.1.1.21	0.650
3lql	LDT	Aldose reductase	1.1.1.21	0.635
3m4h	388	Aldose reductase	1.1.1.21	0.630
4gca	2X9	Aldose reductase	1.1.1.21	0.629
3lbo	LDT	Aldose reductase	1.1.1.21	0.628
1z89	62P	Aldose reductase	1.1.1.21	0.625
2hvo	ZST	Aldose reductase	1.1.1.21	0.618
2ikh	LIT	Aldose reductase	1.1.1.21	0.614
2i16	LDT	Aldose reductase	1.1.1.21	0.613
3ghr	LDT	Aldose reductase	1.1.1.21	0.613
3mb9	ZST	Aldose reductase	1.1.1.21	0.612
2iki	388	Aldose reductase	1.1.1.21	0.611
3g5e	Q74	Aldose reductase	1.1.1.21	0.608
1t41	ID5	Aldose reductase	1.1.1.21	0.597
2pdh	47D	Aldose reductase	1.1.1.21	0.592
2pdp	393	Aldose reductase	1.1.1.21	0.587
2pdu	393	Aldose reductase	1.1.1.21	0.587
1iei	ZES	Aldose reductase	1.1.1.21	0.586
3ghs	LDT	Aldose reductase	1.1.1.21	0.582
3t42	3T4	Aldose reductase	1.1.1.21	0.582
2pzn	393	Aldose reductase	1.1.1.21	0.581
3ld5	LDT	Aldose reductase	1.1.1.21	0.571
2pdf	ZST	Aldose reductase	1.1.1.21	0.570
2pdb	ZST	Aldose reductase	1.1.1.21	0.569
3ghu	LDT	Aldose reductase	1.1.1.21	0.567
1pwl	BFI	Aldose reductase	1.1.1.21	0.565
1us0	LDT	Aldose reductase	1.1.1.21	0.563
2fzd	TOL	Aldose reductase	1.1.1.21	0.559
3len	ZST	Aldose reductase	1.1.1.21	0.556
2pdc	393	Aldose reductase	1.1.1.21	0.553
3m0i	ZST	Aldose reductase	1.1.1.21	0.551
2pdl	TOL	Aldose reductase	1.1.1.21	0.549
2pd5	ZST	Aldose reductase	1.1.1.21	0.548
2pdg	47D	Aldose reductase	1.1.1.21	0.546
3mc5	393	Aldose reductase	1.1.1.21	0.542
2duz	ZST	Aldose reductase	1.1.1.21	0.538
2pdi	ZST	Aldose reductase	1.1.1.21	0.538
2qxw	LDT	Aldose reductase	1.1.1.21	0.534
3ght	LDT	Aldose reductase	1.1.1.21	0.533
2i17	LDT	Aldose reductase	1.1.1.21	0.531
2dux	ZST	Aldose reductase	1.1.1.21	0.529
3lz5	LDT	Aldose reductase	1.1.1.21	0.529
1frb	ZST	Aldose reductase-related protein 2	/	0.526
2pdn	47D	Aldose reductase	1.1.1.21	0.520
1zua	TOL	Aldo-keto reductase family 1 member B10	1.1.1	0.514
2pdq	47D	Aldose reductase	1.1.1.21	0.513
2pdj	393	Aldose reductase	1.1.1.21	0.505
4yu1	53N	Aldose reductase	1.1.1.21	0.499
2iqd	LPA	Aldose reductase	1.1.1.21	0.494
1ah3	TOL	Aldose reductase	1.1.1.21	0.484
2inz	OHP	Aldose reductase	1.1.1.21	0.482
4myq	19T	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.469
1xoq	ROF	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.466
3g4k	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.465
1q9m	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.461
2fzb	TOL	Aldose reductase	1.1.1.21	0.460
1oyn	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.459
4phl	PIL	Phosphodiesterase	/	0.459
5liu	388	Aldo-keto reductase family 1 member B10	1.1.1	0.459
1el3	I84	Aldose reductase	1.1.1.21	0.458
2get	COK	Pantothenate kinase	2.7.1.33	0.456
4jt8	1NR	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.455
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.454
3sl6	JN8	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.453
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.452
2xuj	TZ5	Acetylcholinesterase	3.1.1.7	0.450
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.450
4li6	1XO	Tankyrase-1	2.4.2.30	0.450
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.449
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.448
2ct8	MSP	Methionine--tRNA ligase	6.1.1.10	0.448
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.448
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.448
1y2d	4DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
2f2k	TGG	Aldose reductase	1.1.1.21	0.445
4li8	1XQ	Tankyrase-1	2.4.2.30	0.445
4u16	3C0	Muscarinic acetylcholine receptor M3	/	0.445
2agt	FID	Aldose reductase	1.1.1.21	0.444
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.444
4f1l	0RY	Poly [ADP-ribose] polymerase 14	2.4.2.30	0.444
4jq4	IMN	Aldo-keto reductase family 1 member C2	/	0.444
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.443
3jsx	CC2	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.443
1tbb	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
2pdw	FID	Aldose reductase	1.1.1.21	0.442
3g58	988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.442
4j7g	TRH	PCZA361.3	/	0.442
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.441
2pdy	FID	Aldose reductase	1.1.1.21	0.440
3w5e	NVW	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.440