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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2dteNAIGlucose 1-dehydrogenase related protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2dteNAIGlucose 1-dehydrogenase related protein/1.000
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.530
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.523
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.522
4gh5NADShort-chain dehydrogenase/reductase SDR/0.520
1wntNAPL-xylulose reductase1.1.1.100.519
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.517
1ipeNDPTropinone reductase 21.1.1.2360.513
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.513
1rkxNADCDP-D-glucose-4,6-dehydratase/0.511
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.510
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.509
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.509
4fn4NADShort chain dehydrogenase/0.506
3p19NDPPutative blue fluorescent protein/0.503
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.502
3wdsNADNADH-dependent quinuclidinone reductase/0.501
1pr9NAPL-xylulose reductase1.1.1.100.500
2wsbNADGalactitol dehydrogenase/0.499
4hwkNAPSepiapterin reductase1.1.1.1530.498
4j7xNAPSepiapterin reductase1.1.1.1530.498
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.497
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.497
4j7uNAPSepiapterin reductase1.1.1.1530.495
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.494
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.494
1snyNAPLD36273p/0.493
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.493
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.491
3d3wNAPL-xylulose reductase1.1.1.100.489
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.488
1n5dNDPCarbonyl reductase [NADPH] 1/0.487
5jydNADShort chain dehydrogenase/0.487
1iy8NADLevodione reductase/0.486
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.486
1ae1NAPTropinone reductase 1/0.485
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.485
5lc1NADL-threonine 3-dehydrogenase/0.485
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.484
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.484
1oaaNAPSepiapterin reductase1.1.1.1530.483
2wdzNADGalactitol dehydrogenase/0.483
5jlaNADPutative short-chain dehydrogenase/reductase/0.483
3ak4NADNADH-dependent quinuclidinone reductase/0.482
3w8eNAD3-hydroxybutyrate dehydrogenase/0.482
5idwNAPShort-chain dehydrogenase/reductase SDR/0.482
1xg5NAPDehydrogenase/reductase SDR family member 11/0.480
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.480
3w8dNAD3-hydroxybutyrate dehydrogenase/0.480
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.480
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.479
3toxNAPPutative oxidoreductase/0.479
4dc1NDPPutative ketoacyl reductase1.3.10.477
4qecNAPElxO/0.477
4yagNAIC alpha-dehydrogenase/0.477
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.476
1xkqNDPUncharacterized protein/0.476
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.476
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.475
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.474
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.474
3gy0NAPNAD(P)-dependent oxidoreductase/0.474
3sjuNDPKeto reductase/0.473
4yaiNAIC alpha-dehydrogenase/0.473
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.473
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.470
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.470
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.468
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.467
3a4vNADNDP-sugar epimerase/0.467
4q73FADBifunctional protein PutA/0.467
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.465
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.465
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.464
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.464
3l77NJPShort-chain alcohol dehydrogenase/0.464
3vdqNAD3-hydroxybutyrate dehydrogenase/0.464
1x7hNDPPutative ketoacyl reductase1.3.10.462
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
1zemNADXylitol dehydrogenase/0.460
3qrwNDPPutative ketoacyl reductase1.3.10.460
1i3lNADUDP-glucose 4-epimerase/0.459
1x7gNAPPutative ketoacyl reductase1.3.10.459
2bd0NAPSepiapterin reductase/0.458
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.458
3tn7NJPShort-chain alcohol dehydrogenase/0.457
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
3sx2NADUncharacterized protein/0.454
3uxyNADShort-chain dehydrogenase/reductase SDR/0.454
1gcoNADGlucose 1-dehydrogenase1.1.1.470.453
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.453
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2yy7NADL-threonine dehydrogenase/0.453
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.453
3w8fNAD3-hydroxybutyrate dehydrogenase/0.453
1rwbNADGlucose 1-dehydrogenase1.1.1.470.452
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.452
2jahNDPClavaldehyde dehydrogenase/0.452
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3f1kNAPUncharacterized oxidoreductase YciK10.451
2yutNAPPutative short-chain oxidoreductase/0.450
3lqfNADGalactitol dehydrogenase/0.450
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
1w4zNAPPutative ketoacyl reductase1.3.10.448
2p5uNADUDP-glucose 4-epimerase/0.448
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.448
1mg5NAIAlcohol dehydrogenase1.1.1.10.447
3a1nNADNDP-sugar epimerase/0.447
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.447
3ggoNAIPrephenate dehydrogenase/0.446
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.445
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.445
4bmvNAPShort-chain dehydrogenase/0.445
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.445
1geeNADGlucose 1-dehydrogenase1.1.1.470.444
1g6kNADGlucose 1-dehydrogenase1.1.1.470.442
3uceNDPDehydrogenase/0.442
3tscNADUncharacterized protein/0.441
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.441
4q71FADBifunctional protein PutA/0.441
5jy1NADPutative short-chain dehydrogenase/reductase/0.441