sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2dt5 | NAD | Redox-sensing transcriptional repressor Rex |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2dt5 | NAD | Redox-sensing transcriptional repressor Rex | / | 1.000 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.473 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.472 | |
| 5bqf | NAP | Probable hydroxyacid dehydrogenase protein | / | 0.470 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.457 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.456 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.454 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.453 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.451 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.450 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.447 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1i7l | ATP | Synapsin-2 | / | 0.447 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.447 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.447 | |
| 4z0p | NDP | NAD-dependent dehydrogenase | / | 0.447 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.446 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 3sxn | COA | N-acetyltransferase Eis | / | 0.446 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.446 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.446 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.445 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.444 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.443 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3lu8 | IQX | Serum albumin | / | 0.442 | |
| 3zia | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.442 | |
| 3zuy | TCH | Transporter | / | 0.442 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.440 |