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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2dbzNAPGlyoxylate reductase1.1.1.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2dbzNAPGlyoxylate reductase1.1.1.261.000
5j23A2RPutative 2-hydroxyacid dehydrogenase/0.643
2dbrNAPGlyoxylate reductase1.1.1.260.601
2dbqNAPGlyoxylate reductase1.1.1.260.568
4nu5NADPhosphonate dehydrogenase1.20.1.10.541
4e5nNADPhosphonate dehydrogenase1.20.1.10.528
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2370.526
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.520
4nu6NADPhosphonate dehydrogenase1.20.1.10.518
2w2lNADD-mandelate dehydrogenase/0.517
4e5kNADPhosphonate dehydrogenase1.20.1.10.514
4z0pNDPNAD-dependent dehydrogenase/0.507
4weqNAPNAD-dependent dehydrogenase/0.503
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.502
2hu2NADC-terminal binding protein 1/0.499
3kboNDPGlyoxylate/hydroxypyruvate reductase A/0.495
3kb6NADD-lactate dehydrogenase/0.494
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.491
5bqfNAPProbable hydroxyacid dehydrogenase protein/0.490
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.476
4e5mNAPPhosphonate dehydrogenase1.20.1.10.472
4lcjNADC-terminal-binding protein 2/0.472
1hkuNADC-terminal-binding protein 11.1.10.468
5jlaNADPutative short-chain dehydrogenase/reductase/0.468
1qp8NDP2-hydroxyacid dehydrogenase/0.462
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.460
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
3lu8IQXSerum albumin/0.458
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.458
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.457
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
2omeNADC-terminal-binding protein 2/0.455
4opuFDAConserved Archaeal protein/0.455
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.454
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.454
2zb3NDPProstaglandin reductase 21.3.1.480.454
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
2vn0TDZCytochrome P450 2C8/0.453
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
4cd2FOLDihydrofolate reductase1.5.1.30.452
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.452
1mg5NAIAlcohol dehydrogenase1.1.1.10.451
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.451
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.449
3atzFMNProstaglandin F2a synthase/0.449
4l9kEHFSerum albumin/0.449
4q72FADBifunctional protein PutA/0.449
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.448
1ez4NADL-lactate dehydrogenase1.1.1.270.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4l8u9AZSerum albumin/0.447
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.446
3f1kNAPUncharacterized oxidoreductase YciK10.446
4jbiNDPAlcohol dehydrogenase (Zinc)/0.446
3cifNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
3ukoNADAlcohol dehydrogenase class-3/0.444
4dpwAGSMevalonate diphosphate decarboxylase/0.444
3ggoNAIPrephenate dehydrogenase/0.443
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1uydPU8Heat shock protein HSP 90-alpha/0.442
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.442
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.442
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.442
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.442
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.441
1r2jFADFkbI/0.441
1zemNADXylitol dehydrogenase/0.441
2eklNADD-3-phosphoglycerate dehydrogenase/0.441
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.441
2q4bNAPUncharacterized protein At5g02240/0.441
2y05NAPProstaglandin reductase 1/0.441
3a1nNADNDP-sugar epimerase/0.441
3t2zFADSulfide-quinone reductase/0.441
4qi5FADCellobiose dehydrogenase/0.441
5kjeNAJAlcohol dehydrogenase E chain1.1.1.10.441
4z34ON7Lysophosphatidic acid receptor 1/0.441
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
3f3sNADLambda-crystallin homolog/0.440
3l0lHC3Nuclear receptor ROR-gamma/0.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.440
5br7FADUDP-galactopyranose mutase/0.440
5eoxADPType 4 fimbrial biogenesis protein PilM/0.440