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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2dbqNAPGlyoxylate reductase1.1.1.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2dbqNAPGlyoxylate reductase1.1.1.261.000
2dbzNAPGlyoxylate reductase1.1.1.260.607
4weqNAPNAD-dependent dehydrogenase/0.583
3bazNAPHydroxyphenylpyruvate reductase1.1.1.2370.578
5j23A2RPutative 2-hydroxyacid dehydrogenase/0.551
4z0pNDPNAD-dependent dehydrogenase/0.542
4e5kNADPhosphonate dehydrogenase1.20.1.10.534
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.533
4nu5NADPhosphonate dehydrogenase1.20.1.10.530
5bqfNAPProbable hydroxyacid dehydrogenase protein/0.527
5jlaNADPutative short-chain dehydrogenase/reductase/0.513
4e5mNAPPhosphonate dehydrogenase1.20.1.10.502
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.498
4e5nNADPhosphonate dehydrogenase1.20.1.10.496
3f3sNADLambda-crystallin homolog/0.495
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.494
2w2lNADD-mandelate dehydrogenase/0.492
3e8xNAPBH1520 protein/0.490
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.489
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.488
3kb6NADD-lactate dehydrogenase/0.488
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.486
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.483
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.481
4nu6NADPhosphonate dehydrogenase1.20.1.10.479
3ggoNAIPrephenate dehydrogenase/0.471
1qiqACCIsopenicillin N synthase1.21.3.10.470
3uylTYDProbable NDP-rhamnosyltransferase/0.470
5idwNAPShort-chain dehydrogenase/reductase SDR/0.470
2eklNADD-3-phosphoglycerate dehydrogenase/0.468
1qvnFRIInterleukin-2/0.467
2yy7NADL-threonine dehydrogenase/0.467
3d4pNADL-lactate dehydrogenase 11.1.1.270.467
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.465
1bk0ACVIsopenicillin N synthase1.21.3.10.464
2aa3AP0L-lactate dehydrogenase/0.464
3qrwNDPPutative ketoacyl reductase1.3.10.464
5d3qGDPDynamin-13.6.5.50.464
2iviACWIsopenicillin N synthase1.21.3.10.463
3i0pNADMalate dehydrogenase, putative/0.463
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.463
1mg5NAIAlcohol dehydrogenase1.1.1.10.462
2g5cNADPrephenate dehydrogenase/0.462
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.462
3mj4FADUDP-galactopyranose mutase/0.462
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.462
4b8wNAPGDP-L-fucose synthase1.1.1.2710.462
2yutNAPPutative short-chain oxidoreductase/0.461
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.461
1ae1NAPTropinone reductase 1/0.460
2jb4A14Isopenicillin N synthase1.21.3.10.460
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.460
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.460
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.459
2ym2NAPPhenylacetone monooxygenase1.14.13.920.459
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.459
1hkuNADC-terminal-binding protein 11.1.10.458
1ipeNDPTropinone reductase 21.1.1.2360.458
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.458
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.457
2vbdV10Isopenicillin N synthase1.21.3.10.457
3ft8MOJHeat shock protein HSP 90-alpha/0.457
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.457
4bb3KKAIsopenicillin N synthase1.21.3.10.457
5kjeNAJAlcohol dehydrogenase E chain1.1.1.10.457
1blzACVIsopenicillin N synthase1.21.3.10.456
1ojtFADDihydrolipoyl dehydrogenase/0.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
2x0iNAIMalate dehydrogenase/0.456
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.456
3sglFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.456
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.455
1qjfACSIsopenicillin N synthase1.21.3.10.455
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.455
6adhNADAlcohol dehydrogenase E chain1.1.1.10.455
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.454
4yagNAIC alpha-dehydrogenase/0.454
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.454
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2daaDCSD-alanine aminotransferase2.6.1.210.453
3h3jNADL-lactate dehydrogenase 11.1.1.270.453
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.453
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.452
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.452
1hb3SCVIsopenicillin N synthase1.21.3.10.451
1oaaNAPSepiapterin reductase1.1.1.1530.451
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.451
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.451
3intFDAUDP-galactopyranose mutase5.4.99.90.451
3uceNDPDehydrogenase/0.451
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.451
4i1iNADMalate dehydrogenase/0.451
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.451
2hu2NADC-terminal binding protein 1/0.450
2y6fM9FIsopenicillin N synthase1.21.3.10.450
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3hdyFDAUDP-galactopyranose mutase/0.450
3mnrSD1Heat shock protein HSP 90-alpha/0.450
3zoiM2WIsopenicillin N synthase1.21.3.10.450
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.450
5kj6NAJAlcohol dehydrogenase E chain1.1.1.10.450
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.449
1hb1OCVIsopenicillin N synthase1.21.3.10.449
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.449
2tpsTPSThiamine-phosphate synthase/0.449
3uxyNADShort-chain dehydrogenase/reductase SDR/0.449
4a1zADPKinesin-like protein KIF11/0.449
4dbzNDPPutative ketoacyl reductase1.3.10.449
3ai2NDPNADPH-sorbose reductase/0.448
3gyqSAM23S rRNA (adenosine(1067)-2'-O)-methyltransferase/0.448
3mjhGTPRas-related protein Rab-5A/0.448
3sjuNDPKeto reductase/0.448
3uteFADUDP-galactopyranose mutase/0.448
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.448
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.448
1hf3NADAlcohol dehydrogenase E chain1.1.1.10.447
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
3cgcCOACoenzyme A disulfide reductase/0.447
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.447
1xq6NAPUncharacterized protein At5g02240/0.446
2b56UTPRNA editing complex protein MP57/0.446
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.446
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.446
2pmdGNPTranslation initiation factor 2 subunit gamma/0.446
3rj5NADAlcohol dehydrogenase1.1.1.10.446
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.446
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.446
1ma0NADAlcohol dehydrogenase class-31.1.1.10.445
2fzmFADBifunctional protein PutA1.5.5.20.445
4jc51K5Stimulator of interferon genes protein/0.445
4uymVOR14-alpha sterol demethylase Cyp51B/0.445
1g4tFTPThiamine-phosphate synthase/0.444
1knuYPAPeroxisome proliferator-activated receptor gamma/0.444
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
1w4zNAPPutative ketoacyl reductase1.3.10.444
3wfjNAD2-dehydropantoate 2-reductase/0.444
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.444
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.444
4yaiNAIC alpha-dehydrogenase/0.444
1do8NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.443
1emdNADMalate dehydrogenase/0.443
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.443
2ywwATPAspartate carbamoyltransferase regulatory chain/0.443
3gy0NAPNAD(P)-dependent oxidoreductase/0.443
4j7uNAPSepiapterin reductase1.1.1.1530.443
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.443
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.442
1pr9NAPL-xylulose reductase1.1.1.100.442
1uymPU3Heat shock protein HSP 90-beta/0.442
1vyrFMNPentaerythritol tetranitrate reductase/0.442
2q4bNAPUncharacterized protein At5g02240/0.442
3rj9NADAlcohol dehydrogenase1.1.1.10.442
4dc1NDPPutative ketoacyl reductase1.3.10.442
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.442
4jbiNDPAlcohol dehydrogenase (Zinc)/0.442
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.442
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.442
1fy7COAHistone acetyltransferase ESA1/0.441
1ptjSNDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
1z7eATPBifunctional polymyxin resistance protein ArnA/0.441
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.441
3kybFADUDP-galactopyranose mutase5.4.99.90.441
3p62FMNPentaerythritol tetranitrate reductase/0.441
3sufSUEPolyprotein/0.441
4j7xNAPSepiapterin reductase1.1.1.1530.441
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.441
5lc1NADL-threonine 3-dehydrogenase/0.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.440
1qvrANPChaperone protein ClpB/0.440
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.440
3k3bADPKinesin-like protein KIF11/0.440
4rpjFADUDP-galactopyranose mutase5.4.99.90.440
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.440