sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2clo | PLS | Tryptophan synthase beta chain | 4.2.1.20 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2clo | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 1.000 | |
| 2tys | PLT | Tryptophan synthase beta chain | 4.2.1.20 | 0.626 | |
| 1kfj | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.613 | |
| 5dw0 | PLS | Tryptophan synthase beta chain 1 | 4.2.1.20 | 0.608 | |
| 2trs | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.597 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.495 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.483 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.482 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.482 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.480 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.480 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.480 | |
| 5a3b | APR | SIR2 family protein | / | 0.480 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.478 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.477 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.476 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.476 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.475 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.475 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.475 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.475 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.474 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.474 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.473 | |
| 3bxs | DRS | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 1ty9 | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.472 | |
| 2w03 | ADN | AcsD | / | 0.472 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.472 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.472 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.472 | |
| 2bgj | FAD | NADPH:ferredoxin reductase | / | 0.471 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.471 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.471 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.471 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.470 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.470 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.470 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.470 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.469 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.469 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.468 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.468 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.468 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.468 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.467 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.467 | |
| 3a6r | FMN | FMN-binding protein | / | 0.467 | |
| 3v2u | ATP | Protein GAL3 | / | 0.467 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.467 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.466 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.466 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.466 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.466 | |
| 1xdi | FAD | NAD(P)H dehydrogenase (quinone) | / | 0.465 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.465 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.465 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.465 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.464 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 2ejz | SAH | Diphthine synthase | / | 0.464 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.464 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.464 | |
| 4eeu | FMN | Phototropin-2 | 2.7.11.1 | 0.464 | |
| 4l8u | 9AZ | Serum albumin | / | 0.464 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2q54 | MU1 | Protease | / | 0.463 | |
| 3rdq | DTB | Streptavidin | / | 0.463 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.462 | |
| 1mx0 | ANP | Type 2 DNA topoisomerase 6 subunit B | / | 0.461 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.461 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.461 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.461 | |
| 2ydx | STL | Methionine adenosyltransferase 2 subunit beta | / | 0.461 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.461 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.461 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.460 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.460 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.460 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2ido | TMP | DNA polymerase III subunit epsilon | 2.7.7.7 | 0.460 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.460 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.460 | |
| 3b9l | AZZ | Serum albumin | / | 0.460 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.460 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.460 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.460 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 4hge | 15V | Tyrosine-protein kinase JAK2 | / | 0.460 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.459 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.459 | |
| 1owo | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.459 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.459 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.459 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.458 | |
| 1z5a | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.458 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.458 | |
| 2x3j | ATP | AcsD | / | 0.458 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.458 | |
| 4xr9 | TMP | CalS8 | / | 0.458 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.457 | |
| 2o4g | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.457 | |
| 2v1a | FMN | NPH1-1 | / | 0.457 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.457 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.457 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.457 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.457 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.457 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.457 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.457 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.457 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.456 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.456 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.456 | |
| 1k2c | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2cah | NDP | Catalase | 1.11.1.6 | 0.455 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.455 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.455 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.455 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.455 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.455 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.455 | |
| 3r7c | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.455 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.455 | |
| 3u04 | BB2 | Peptide deformylase | / | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.455 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.454 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.454 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.454 | |
| 3k4v | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.454 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.454 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.454 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.454 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.454 | |
| 1pme | SB2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 1ung | ALH | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.453 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.453 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.453 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.453 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4cnz | ADP | Nitrogen regulatory protein P-II 1 | / | 0.453 | |
| 4h3y | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.453 | |
| 4iae | 1DX | Alr2278 protein | / | 0.453 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.453 | |
| 5a3c | NAD | SIR2 family protein | / | 0.453 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.452 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.452 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.452 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 2ydf | IO3 | Serum albumin | / | 0.452 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.452 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.452 | |
| 3rpr | 25Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.452 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.452 | |
| 4iah | 1DX | Alr2278 protein | / | 0.452 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.452 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1c70 | L75 | Protease | / | 0.451 | |
| 1e8h | ADP | Vanillyl-alcohol oxidase | 1.1.3.38 | 0.451 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.451 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.451 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.451 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.451 | |
| 1zdw | FLV | Prenyltransferase | / | 0.451 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.451 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.451 | |
| 2f2u | M77 | Rho-associated protein kinase 2 | 2.7.11.1 | 0.451 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.451 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 3i2l | 2NC | Protease | / | 0.451 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.451 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.451 | |
| 4rnx | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.450 | |
| 1hvi | A77 | Protease | / | 0.450 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.450 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.450 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.450 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.450 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.450 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 3p23 | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.450 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4azm | T4B | Fatty acid-binding protein, epidermal | / | 0.450 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.450 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.450 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.449 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.449 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2e83 | FMN | FMN-binding protein | / | 0.449 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.449 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.449 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.449 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.449 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.449 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.449 | |
| 4irn | FAD | AnaB | / | 0.449 | |
| 4q4k | FMN | Uncharacterized protein | / | 0.449 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.448 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.448 | |
| 1oyc | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.448 | |
| 1r2j | FAD | FkbI | / | 0.448 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2nmy | ROC | Protease | / | 0.448 | |
| 2xvw | 9NR | Serum albumin | / | 0.448 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.448 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.448 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.448 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.448 | |
| 4ojb | 198 | Androgen receptor | / | 0.448 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.447 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1hk1 | T44 | Serum albumin | / | 0.447 | |
| 1mrx | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.447 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.447 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.447 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.447 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 2b9x | FAD | Putative aminooxidase | / | 0.447 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.447 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.447 | |
| 4f9b | 0SY | Cell division cycle 7-related protein kinase | 2.7.11.1 | 0.447 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.447 | |
| 5cds | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 5cvc | PLP | Serine racemase | / | 0.447 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.446 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.446 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.446 | |
| 1lv8 | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1nw4 | IMH | Purine nucleoside phosphorylase | / | 0.446 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.446 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.446 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.446 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.446 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.446 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.446 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.446 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.446 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.446 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.446 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.446 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.446 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.446 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.445 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.445 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.445 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.445 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 3arv | SAU | Chitinase A | / | 0.445 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3q9z | TXQ | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.445 | |
| 4ho9 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.445 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.445 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.445 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1f3b | GBX | Glutathione S-transferase A1 | 2.5.1.18 | 0.444 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.444 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 1vcf | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.444 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.444 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2w02 | ATP | AcsD | / | 0.444 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.444 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 3zuy | TCH | Transporter | / | 0.444 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.444 | |
| 4hxo | 1A6 | Bromodomain-containing protein 4 | / | 0.444 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.444 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.444 | |
| 4okb | 198 | Androgen receptor | / | 0.444 | |
| 4okx | 198 | Androgen receptor | / | 0.444 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.444 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.443 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.443 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.443 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.443 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2rc3 | NAD | CBS domain | / | 0.443 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.443 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.443 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3fow | IMH | Purine nucleoside phosphorylase | / | 0.443 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 3tiz | 3TI | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3up0 | D7S | aceDAF-12 | / | 0.443 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.443 | |
| 4a0m | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.443 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.443 | |
| 4bmp | FMN | Protein NrdI | / | 0.443 | |
| 4egn | TWO | Cytochrome P450 | / | 0.443 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4l9q | 9TP | Serum albumin | / | 0.443 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.443 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.443 | |
| 4o74 | R78 | Bromodomain-containing protein 4 | / | 0.443 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.443 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1b6l | PI4 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.442 | |
| 1qxo | FMN | Chorismate synthase | / | 0.442 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1xjj | DGT | Vitamin B12-dependent ribonucleotide reductase | / | 0.442 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.442 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.442 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.442 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.442 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.441 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.441 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.441 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.441 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.441 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.441 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.441 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 2vcx | D26 | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 2xb5 | I7T | Tetracycline repressor protein class D | / | 0.441 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.441 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.441 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.441 | |
| 3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.441 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.441 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4aub | NAP | L-glyceraldehyde 3-phosphate reductase | 1.1.1 | 0.441 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 4eiq | KCT | Putative FAD-monooxygenase | / | 0.441 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.441 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.441 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.441 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.440 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1pr0 | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 1szc | CNA | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.440 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.440 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2zre | AGS | Protein RecA | / | 0.440 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.440 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.440 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.440 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.440 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 4b10 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.440 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4m69 | ANP | Receptor-interacting serine/threonine-protein kinase 3 | 2.7.11.1 | 0.440 | |
| 4tta | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 |