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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.11.000
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.665
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.604
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.594
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.584
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.574
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.569
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.565
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.558
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.557
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.554
2hog710Serine/threonine-protein kinase Chk12.7.11.10.543
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.534
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.531
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.530
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.528
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.526
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.526
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.525
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.523
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.523
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.522
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.521
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.521
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.521
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.520
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.518
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.516
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.514
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.511
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.511
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.510
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.510
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.509
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.509
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.509
3a62STURibosomal protein S6 kinase beta-12.7.11.10.508
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.508
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.508
1jklANPDeath-associated protein kinase 12.7.11.10.507
3i60E86Mitogen-activated protein kinase 12.7.11.240.507
5av2KMPDeath-associated protein kinase 12.7.11.10.507
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.506
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.505
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.505
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.504
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.504
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.503
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.501
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.500
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.500
3c4xATPRhodopsin kinase/0.499
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.498
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.498
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.497
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.497
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.495
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.494
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.493
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.493
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.492
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.492
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.492
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.492
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.491
1zys199Serine/threonine-protein kinase Chk12.7.11.10.490
2j0lANPFocal adhesion kinase 12.7.10.20.490
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.490
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.489
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.489
3t8oATPRhodopsin kinase/0.488
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.488
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.487
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.487
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.487
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.487
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.486
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.486
3zewSTUEphrin type-B receptor 42.7.10.10.486
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.485
4fv6E57Mitogen-activated protein kinase 12.7.11.240.485
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.484
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.484
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3zh8C58Protein kinase C iota type2.7.11.130.483
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.482
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.482
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.482
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.482
4ysjADPCalmodulin-like domain protein kinase/0.482
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.481
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.481
2uzbC75Cyclin-dependent kinase 22.7.11.220.481
4aguD15Cyclin-dependent kinase-like 1/0.481
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.480
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.479
4btjATPTau-tubulin kinase 12.7.11.10.479
4l9i8PRRhodopsin kinase/0.479
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.478
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.478
4j99ACPFibroblast growth factor receptor 2/0.478
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.477
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.477
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.477
3gu6ADPDeath-associated protein kinase 12.7.11.10.477
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.477
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.476
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.475
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.475
5av3KMPDeath-associated protein kinase 12.7.11.10.475
1yvj4STTyrosine-protein kinase JAK32.7.10.20.474
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.474
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.474
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.474
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.474
2yaaATPDeath-associated protein kinase 2/0.474
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.474
4hvi19STyrosine-protein kinase JAK32.7.10.20.474
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.473
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.473
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.472
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.472
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.472
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.472
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.472
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.471
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.471
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2j0m4STFocal adhesion kinase 12.7.10.20.470
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.470
2ckeIQUDeath-associated protein kinase 2/0.469
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.469
4bbfO19Tyrosine-protein kinase JAK2/0.469
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
5cvfATPCasein kinase II subunit alpha2.7.11.10.469
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.468
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2yn8STUEphrin type-B receptor 42.7.10.10.468
4bcmT7ZCyclin-dependent kinase 22.7.11.220.468
4c57FEFCyclin-G-associated kinase2.7.11.10.468
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.467
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.467
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.467
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.467
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.466
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.466
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2vu3LZECyclin-dependent kinase 22.7.11.220.466
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.466
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.466
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.466
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.466
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.466
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4qnyANPMitogen activated protein kinase, putative/0.465
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.464
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.464
2x6dX6DAurora kinase A2.7.11.10.463
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.463
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.463
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.462
2ijmADPFocal adhesion kinase 12.7.10.20.462
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.462
3gu7ADPDeath-associated protein kinase 12.7.11.10.462
3lltANPProtein serine/threonine kinase-1/0.462
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.462
4e6d0NUTyrosine-protein kinase JAK2/0.462
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.462
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.461
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.461
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.461
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.460
1qmzATPCyclin-dependent kinase 22.7.11.220.459
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.459
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4j95ACPFibroblast growth factor receptor 2/0.459
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.459
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.458
4cd0AWJALK tyrosine kinase receptor2.7.10.10.458
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.458
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.458
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.457
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.457
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.457
3bqr4RBDeath-associated protein kinase 3/0.457
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.457
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.457
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.456
5e8ySTUTGF-beta receptor type-22.7.11.300.456
4i5cC5ITyrosine-protein kinase JAK1/0.455
2c4g514Cyclin-dependent kinase 22.7.11.220.454
2ojj82AMitogen-activated protein kinase 12.7.11.240.454
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.454
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
4c3pACPAurora kinase A2.7.11.10.453
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.453
4fv9E71Mitogen-activated protein kinase 12.7.11.240.453
4gmy0X5Tyrosine-protein kinase JAK2/0.453
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.453
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.453
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.452
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.452
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.452
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.452
1finATPCyclin-dependent kinase 22.7.11.220.451
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.451
1k6cMK1Gag-Pol polyprotein3.4.23.160.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
4hgs15GCasein kinase I isoform gamma-32.7.11.10.450
4ii5ADPCyclin-dependent kinase 22.7.11.220.450
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.449
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.449
4jia1K3Tyrosine-protein kinase JAK2/0.449
1jkkANPDeath-associated protein kinase 12.7.11.10.448
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.448
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1fvv107Cyclin-dependent kinase 22.7.11.220.447
2in6839Wee1-like protein kinase2.7.10.20.447
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4eooATPCyclin-dependent kinase 22.7.11.220.447
5auwQUEDeath-associated protein kinase 12.7.11.10.447
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.446
3dfcANPDeath-associated protein kinase 12.7.11.10.446
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.446
3bu5ATPInsulin receptor2.7.10.10.445
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.445
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.445
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.444
4aqc88ATyrosine-protein kinase JAK2/0.444
4o0wADNAurora kinase A2.7.11.10.444
2w17I19Cyclin-dependent kinase 22.7.11.220.443
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.443
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.443
4j97ACPFibroblast growth factor receptor 2/0.443
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.442
3sheI85MAP kinase-activated protein kinase 32.7.11.10.442
4fx360KCyclin-dependent kinase 22.7.11.220.442
4hge15VTyrosine-protein kinase JAK2/0.442
4ji91M3Tyrosine-protein kinase JAK2/0.442
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4e4n0NLTyrosine-protein kinase JAK1/0.441
4f081RSTyrosine-protein kinase JAK2/0.441
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.441
5dosATPAurora kinase A2.7.11.10.441
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.440
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2z2w770Wee1-like protein kinase2.7.10.20.440
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3my5RFZCyclin-dependent kinase 22.7.11.220.440
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.440
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440
4ivb1J5Tyrosine-protein kinase JAK1/0.440