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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.596
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.566
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.562
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.553
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.506
2r9zFADGlutathione amide reductase/0.504
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.499
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.499
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.495
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.494
4j56FADThioredoxin reductase 21.8.1.90.493
2v6oFADThioredoxin glutathione reductase/0.488
3grsFADGlutathione reductase, mitochondrial1.8.1.70.488
1greFADGlutathione reductase, mitochondrial1.8.1.70.487
1grhFADGlutathione reductase, mitochondrial1.8.1.70.487
1gerFADGlutathione reductase1.8.1.70.486
1grgFADGlutathione reductase, mitochondrial1.8.1.70.484
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.482
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.477
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.476
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.476
1graFADGlutathione reductase, mitochondrial1.8.1.70.464
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.464
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.463
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.459
1febFADTrypanothione reductase1.8.1.120.455
2rabFADGlutathione amide reductase/0.455
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.451
4nevFADTrypanothione reductase/0.451
1geuFADGlutathione reductase1.8.1.70.448
3ic9FADPutative dihydrolipoamide dehydrogenase/0.448
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.442