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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.11.000
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.518
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.512
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.510
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.507
1bygSTUTyrosine-protein kinase CSK/0.506
1eh4IC1Casein kinase I homolog 12.7.11.10.505
3a62STURibosomal protein S6 kinase beta-12.7.11.10.503
3zewSTUEphrin type-B receptor 42.7.10.10.502
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.502
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.500
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.497
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.496
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.495
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.493
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.493
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.491
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.490
2pvnP63Casein kinase II subunit alpha2.7.11.10.487
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.486
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.485
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.485
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.483
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.482
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.482
3gubGUBDeath-associated protein kinase 12.7.11.10.481
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.481
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.480
2yn8STUEphrin type-B receptor 42.7.10.10.480
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.480
2pvmP29Casein kinase II subunit alpha2.7.11.10.478
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.477
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.477
3w33W19Epidermal growth factor receptor2.7.10.10.476
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.476
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.475
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.475
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.475
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.474
4c02TAKActivin receptor type-12.7.11.300.474
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.474
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.474
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.473
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.473
2xngA0HAurora kinase A2.7.11.10.472
3iok1P6Tyrosine-protein kinase JAK2/0.472
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.472
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.472
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.471
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.470
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.470
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.470
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.470
5dpvSKEAurora kinase A2.7.11.10.470
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4y95746Tyrosine-protein kinase/0.469
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.468
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.468
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.468
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.468
4jq8KJ8Epidermal growth factor receptor2.7.10.10.468
1g5sI17Cyclin-dependent kinase 22.7.11.220.467
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.467
4hvi19STyrosine-protein kinase JAK32.7.10.20.467
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.466
4hge15VTyrosine-protein kinase JAK2/0.466
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.465
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.465
3be9P04Casein kinase II subunit alpha2.7.11.10.465
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.465
4y93746Tyrosine-protein kinase/0.465
2in6839Wee1-like protein kinase2.7.10.20.464
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.464
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.464
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.463
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.463
3pxkPXKFocal adhesion kinase 12.7.10.20.463
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.463
3eb0DRKUncharacterized protein/0.462
3rmf20ZCyclin-dependent kinase 22.7.11.220.462
3zh8C58Protein kinase C iota type2.7.11.130.462
4kbk1QGCasein kinase I isoform delta2.7.11.10.462
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.461
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.461
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2w1hL0FCyclin-dependent kinase 22.7.11.220.461
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.461
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.461
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.461
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.461
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
2pvhP19Casein kinase II subunit alpha2.7.11.10.460
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.460
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.460
3r9dX6BCyclin-dependent kinase 22.7.11.220.460
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.460
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.459
3gxlQIGTGF-beta receptor type-12.7.11.300.459
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.459
3rvg17PTyrosine-protein kinase JAK2/0.459
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.459
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
5dr6SKEAurora kinase A2.7.11.10.459
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.458
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
2hog710Serine/threonine-protein kinase Chk12.7.11.10.458
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.458
2zoq5IDMitogen-activated protein kinase 32.7.11.240.458
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.458
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.458
4o0sADNAurora kinase A2.7.11.10.458
1h1r6CPCyclin-dependent kinase 22.7.11.220.457
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.457
4bcmT7ZCyclin-dependent kinase 22.7.11.220.457
4c62XWWTyrosine-protein kinase JAK2/0.457
4riyADPEpidermal growth factor receptor2.7.10.10.457
1oguST8Cyclin-dependent kinase 22.7.11.220.456
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.456
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.456
4c61LMMTyrosine-protein kinase JAK2/0.456
4gub0Y4Casein kinase II subunit alpha2.7.11.10.456
4jqeANPCasein kinase II subunit alpha2.7.11.10.456
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.455
1xjdSTUProtein kinase C theta type2.7.11.130.455
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2dwbANPAurora kinase A2.7.11.10.455
2itpAEEEpidermal growth factor receptor2.7.10.10.455
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.454
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.454
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.453
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.453
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.453
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.453
2x6dX6DAurora kinase A2.7.11.10.453
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.453
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.453
4gk3L87Ephrin type-A receptor 32.7.10.10.453
4jajXU1Aurora kinase A2.7.11.10.453
1wvxBD4Death-associated protein kinase 12.7.11.10.452
3lfnA27Cyclin-dependent kinase 22.7.11.220.452
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.452
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.452
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4i22IREEpidermal growth factor receptor2.7.10.10.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.451
1u54ACPActivated CDC42 kinase 1/0.451
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.451
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.451
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
1aq1STUCyclin-dependent kinase 22.7.11.220.450
1gii1PUCyclin-dependent kinase 22.7.11.220.450
1m2pHNACasein kinase II subunit alpha2.7.11.10.450
1py5PY1TGF-beta receptor type-12.7.11.300.450
1pyePM1Cyclin-dependent kinase 22.7.11.220.450
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.450
3mtfA3FActivin receptor type-12.7.11.300.450
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.450
3qtrX36Cyclin-dependent kinase 22.7.11.220.450
3u4uLNHCasein kinase II subunit alpha2.7.11.10.450
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.450
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.450
4e4m0NHTyrosine-protein kinase JAK2/0.450
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.450
1m17AQ4Epidermal growth factor receptor2.7.10.10.449
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
2itqITQEpidermal growth factor receptor2.7.10.10.449
2of2547Tyrosine-protein kinase Lck2.7.10.20.449
2vd5BI8Myotonin-protein kinase2.7.11.10.449
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.449
3at3ATKCasein kinase II subunit alpha2.7.11.10.449
3at4CCKCasein kinase II subunit alpha2.7.11.10.449
4jr3KJREpidermal growth factor receptor2.7.10.10.449
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
5dt0SKEAurora kinase A2.7.11.10.449
5e8wSTUTGF-beta receptor type-12.7.11.300.449
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1ke6LS2Cyclin-dependent kinase 22.7.11.220.448
2v7a627Tyrosine-protein kinase ABL12.7.10.20.448
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.448
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.448
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.448
3hmm855TGF-beta receptor type-12.7.11.300.448
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.448
4jq7KJQEpidermal growth factor receptor2.7.10.10.448
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.447
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.447
2of4979Tyrosine-protein kinase Lck2.7.10.20.447
2vu3LZECyclin-dependent kinase 22.7.11.220.447
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.447
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.447
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.446
1vjy460TGF-beta receptor type-12.7.11.300.446
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.446
2itnANPEpidermal growth factor receptor2.7.10.10.446
2j7t274Serine/threonine-protein kinase 102.7.11.10.446
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
4ewhT77Activated CDC42 kinase 1/0.446
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4nka2K7Fibroblast growth factor receptor 1/0.446
5dr9SKEAurora kinase A2.7.11.10.446
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.445
3uyt0CKCasein kinase I isoform delta2.7.11.10.445
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.445
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.445
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.444
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.444
2c5nCK8Cyclin-dependent kinase 22.7.11.220.444
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.444
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.444
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.444
3ggfGVDSerine/threonine-protein kinase 26/0.444
4ez50RSCyclin-dependent kinase 62.7.11.220.444
4hjoAQ4Epidermal growth factor receptor2.7.10.10.444
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.443
1m2rMNYCasein kinase II subunit alpha2.7.11.10.443
1oiyN41Cyclin-dependent kinase 22.7.11.220.443
1sh9RITGag-Pol polyprotein3.4.23.160.443
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.443
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.443
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3emg685Tyrosine-protein kinase SYK2.7.10.20.443
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
4hvh19RTyrosine-protein kinase JAK32.7.10.20.443
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.443
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4yuqKS1Calmodulin-like domain protein kinase/0.443
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2izuP01Casein kinase I isoform gamma-32.7.11.10.442
2vtqLZACyclin-dependent kinase 22.7.11.220.442
2w05FRTCyclin-dependent kinase 22.7.11.220.442
3s2pPMUCyclin-dependent kinase 22.7.11.220.442
3t8oATPRhodopsin kinase/0.442
4anmWULCasein kinase II subunit alpha2.7.11.10.442
4b99R4LMitogen-activated protein kinase 72.7.11.240.442
4j97ACPFibroblast growth factor receptor 2/0.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
2uxpCLMHTH-type transcriptional regulator TtgR/0.441
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.441
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.441
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.441
3rak03ZCyclin-dependent kinase 22.7.11.220.441
3t113T1Gag-Pol polyprotein3.4.23.160.441
4dymIYZActivin receptor type-12.7.11.300.441
4f640S8Fibroblast growth factor receptor 1/0.441
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.441
5e8xSTUTGF-beta receptor type-12.7.11.300.441
1di8DTQCyclin-dependent kinase 22.7.11.220.440
1gih1PUCyclin-dependent kinase 22.7.11.220.440
1k6vXN2Gag-Pol polyprotein3.4.23.160.440
2b7aIZATyrosine-protein kinase JAK2/0.440
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.440
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.440
4bbfO19Tyrosine-protein kinase JAK2/0.440
4erwSTUCyclin-dependent kinase 22.7.11.220.440
4hgt15GCasein kinase I isoform delta2.7.11.10.440
4jia1K3Tyrosine-protein kinase JAK2/0.440
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.440
5aaaVGHALK tyrosine kinase receptor2.7.10.10.440
5dt3ATPAurora kinase A2.7.11.10.440