sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 1.000 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.562 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.551 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.546 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.539 | |
| 2fr3 | REA | Cellular retinoic acid-binding protein 2 | / | 0.525 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.520 | |
| 2cbs | R13 | Cellular retinoic acid-binding protein 2 | / | 0.519 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.498 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.498 | |
| 5dp2 | NAP | CurF | / | 0.497 | |
| 3eks | CY9 | Actin-5C | / | 0.496 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.496 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.495 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.488 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.485 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.483 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.483 | |
| 1khr | COA | Streptogramin A acetyltransferase | 2.3.1 | 0.482 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.482 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.482 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.481 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.481 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.481 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.481 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.480 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.479 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.479 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.478 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.477 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.477 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.476 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.475 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.475 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.474 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.474 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.474 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.473 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.473 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.472 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.472 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.472 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.472 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.471 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.471 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.471 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.471 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.471 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.470 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.470 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.470 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.469 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.469 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.469 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.468 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.468 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.468 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.467 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.467 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.467 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.467 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.467 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.467 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.466 | |
| 4l8u | 9AZ | Serum albumin | / | 0.466 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.465 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.465 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 1osv | CHC | Bile acid receptor | / | 0.464 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.464 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.464 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.464 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.464 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.464 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.464 | |
| 1nqw | 5YL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.463 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.463 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.462 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.462 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.461 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.461 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.461 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.460 | |
| 1xh8 | R55 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.460 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.460 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.460 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.460 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.459 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.459 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.459 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.459 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.459 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.458 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.458 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.458 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.458 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.458 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.457 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.457 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.457 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.457 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.457 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.456 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.456 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.456 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.456 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.456 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.455 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.455 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.455 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.455 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.455 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.455 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1owl | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.454 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.454 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.454 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.454 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.454 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.454 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.454 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3vqu | O22 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.454 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.454 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.454 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.454 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.453 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.453 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.453 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.453 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.453 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.453 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.452 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.452 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 3v2u | ATP | Protein GAL3 | / | 0.452 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.452 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.452 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.452 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.452 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.451 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.451 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.451 | |
| 1o1v | TCH | Gastrotropin | / | 0.451 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.451 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.451 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.451 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.451 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.451 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.451 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.451 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.451 | |
| 4tm4 | FDA | KtzI | / | 0.451 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.451 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.451 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.451 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.450 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.450 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.450 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.450 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.450 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.450 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.449 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.449 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.449 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.449 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.449 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.449 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.449 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.449 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.449 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.448 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 2h12 | CMX | Citrate synthase | / | 0.448 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3eku | CY9 | Actin-5C | / | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.447 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.447 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.447 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.447 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.447 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.447 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.446 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.446 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1wua | AP8 | Actin, alpha skeletal muscle | / | 0.446 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.446 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.446 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 2vq5 | LDP | S-norcoclaurine synthase | / | 0.446 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.446 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.446 | |
| 3dl0 | AP5 | Adenylate kinase | / | 0.446 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.446 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.446 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.445 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.445 | |
| 1pz0 | NAP | Protein IolS | 1.1.1 | 0.445 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.445 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.445 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.445 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.445 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.445 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.445 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.445 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4h80 | 04T | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.445 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.445 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.445 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.445 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.445 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.444 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.444 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.444 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.444 | |
| 3gdv | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.444 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.444 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.444 | |
| 3zia | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.444 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.444 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.444 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.444 | |
| 4tm1 | FDA | KtzI | / | 0.444 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.443 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.443 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.443 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.443 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.443 | |
| 2gmj | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.443 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.443 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.443 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.443 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.443 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.443 | |
| 3zuy | TCH | Transporter | / | 0.443 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.443 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.443 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.443 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.443 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.443 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.442 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.442 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.442 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.442 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2oz6 | CMP | Cyclic AMP receptor-like protein | / | 0.442 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.442 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4dsh | FDA | Uncharacterized protein | / | 0.442 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.442 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.442 | |
| 4p13 | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.442 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.442 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.441 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.441 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.441 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.441 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.441 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.441 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 2jfz | 003 | Glutamate racemase | / | 0.441 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3cmc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.441 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 3gpc | COA | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.441 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.441 | |
| 3mj4 | FAD | UDP-galactopyranose mutase | / | 0.441 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.441 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.441 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.441 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.441 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.441 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.441 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.440 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.440 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2zja | ACP | ATP-dependent DNA helicase Hel308 | / | 0.440 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.440 | |
| 3nf4 | FAD | Acyl-CoA dehydrogenase domain-containing protein | / | 0.440 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3wbf | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.440 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.440 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.440 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.440 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.440 | |
| 4yau | 2AM | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.440 |