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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bxhIOSSerum albumin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2bxhIOSSerum albumin/1.000
1iinUPGGlucose-1-phosphate thymidylyltransferase2.7.7.240.469
1mp5UPGGlucose-1-phosphate thymidylyltransferase2.7.7.240.464
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.460
1wc5APCAdenylate cyclase/0.459
2cmkCDPCytidylate kinase2.7.4.250.458
2rc3NADCBS domain/0.458
5kgpACOPredicted acetyltransferase/0.458
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.454
4zasTYDCalS13/0.452
1wc1TATAdenylate cyclase/0.448
3zc3NAPFerredoxin--NADP reductase1.18.1.20.448
3nt6COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.447
5cnsCDPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.447
1g1lDAUGlucose-1-phosphate thymidylyltransferase/0.446
4oviN01Phenylacetone monooxygenase1.14.13.920.445
1z2iNADPutative malate dehydrogenase/0.444
3cx4ADPGlycogen synthase2.4.1.210.444
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2ym2NAPPhenylacetone monooxygenase1.14.13.920.443
5f1cATPUncharacterized protein/0.442
1tllNAPNitric oxide synthase, brain1.14.13.390.440
3lnv1ZZSaframycin Mx1 synthetase B/0.440