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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bbqPFGThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2bbqPFGThymidylate synthase/1.000
1tduCB3Thymidylate synthase/0.619
1zprCB3Thymidylate synthase/0.596
1kceCB3Thymidylate synthase/0.572
1an5CB3Thymidylate synthase/0.563
4gevCB3Thymidylate synthase/0.563
1jtqLY3Thymidylate synthase/0.561
1nceCB3Thymidylate synthase/0.560
3bgxMEFThymidylate synthase/0.557
1dnaCB3Thymidylate synthase/0.556
1kzjCB3Thymidylate synthase/0.556
1bq1CB3Thymidylate synthase/0.545
1trgCB3Thymidylate synthase/0.542
2ftoCB3Thymidylate synthase/0.539
1jutLYDThymidylate synthase/0.527
2tscCB3Thymidylate synthase/0.526
1aiqCB3Thymidylate synthase/0.522
1kziTHGThymidylate synthase/0.519
4knzCB3Thymidylate synthase/0.517
1fwmCB3Thymidylate synthase/0.511
4fqsLYAThymidylate synthase ThyA/0.510
1tysDHFThymidylate synthase/0.509
1axwMTXThymidylate synthase/0.507
3bhlTHGThymidylate synthase/0.507
1dduCB3Thymidylate synthase/0.498
2kceD16Thymidylate synthase/0.497
1jtuLYBThymidylate synthase/0.495
1ju6LYAThymidylate synthase2.1.1.450.492
1f4fTP3Thymidylate synthase/0.485
2aazCB3Thymidylate synthase2.1.1.450.485
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.483
3bhrTHGThymidylate synthase/0.481
4isk1JYThymidylate synthase/0.481
3uwlFOZThymidylate synthase/0.474
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.472
4fogC2FThymidylate synthase ThyA/0.471
1hvyD16Thymidylate synthase2.1.1.450.464
4ez8DHFThymidylate synthase2.1.1.450.463
1jujLYAThymidylate synthase2.1.1.450.452
4foxD16Thymidylate synthase ThyA/0.451
4o7uTHFThymidylate synthase/0.448
1tsdF89Thymidylate synthase/0.446
1f4gTP4Thymidylate synthase/0.445
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.445