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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ban357Gag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ban357Gag-Pol polyprotein2.7.7.491.000
3is9AC7Gag-Pol polyprotein2.7.7.490.599
1hnvTBOGag-Pol polyprotein2.7.7.490.592
2zd1T27Gag-Pol polyprotein2.7.7.490.588
1tl3H20Gag-Pol polyprotein2.7.7.490.582
3qlhT27Gag-Pol polyprotein2.7.7.490.578
3irxUDRGag-Pol polyprotein2.7.7.490.577
3i0rRT3Gag-Pol polyprotein2.7.7.490.576
1vruAAPGag-Pol polyprotein2.7.7.490.574
4kko1REGag-Pol polyprotein2.7.7.490.574
1tkzH16Gag-Pol polyprotein2.7.7.490.571
1rt4UC1Gag-Pol polyprotein2.7.7.490.569
1tvrTB9Gag-Pol polyprotein2.7.7.490.566
4ko0JLJGag-Pol polyprotein2.7.7.490.560
1tl1H18Gag-Pol polyprotein2.7.7.490.556
2ze2T27Gag-Pol polyprotein2.7.7.490.553
1s9eADBGag-Pol polyprotein2.7.7.490.551
1tktH12Gag-Pol polyprotein2.7.7.490.547
1s1wUC1Gag-Pol polyprotein2.7.7.490.544
4id5T27Gag-Pol polyprotein2.7.7.490.544
1rt5UC2Gag-Pol polyprotein2.7.7.490.541
3lamKRPGag-Pol polyprotein2.7.7.490.541
4g1qT27Gag-Pol polyprotein2.7.7.490.541
2rf2MRXGag-Pol polyprotein2.7.7.490.533
1fk9EFZGag-Pol polyprotein2.7.7.490.532
1s6qTPBGag-Pol polyprotein2.7.7.490.532
1revTB9Gag-Pol polyprotein2.7.7.490.531
2vg7NNIGag-Pol polyprotein2.7.7.490.529
1ikwEFZGag-Pol polyprotein2.7.7.490.527
1c1bGCAGag-Pol polyprotein2.7.7.490.526
4i2pG73Gag-Pol polyprotein2.7.7.490.526
1hpzAAPGag-Pol polyprotein2.7.7.490.522
1eetBFUGag-Pol polyprotein2.7.7.490.521
4ifvT27Gag-Pol polyprotein2.7.7.490.521
1rt2TNKGag-Pol polyprotein2.7.7.490.519
4i7fNVEGag-Pol polyprotein2.7.7.490.518
1ikxPNUGag-Pol polyprotein2.7.7.490.517
3ffi3OBGag-Pol polyprotein2.7.7.490.516
3meeT27Gag-Pol polyprotein2.7.7.490.515
1ikyMSDGag-Pol polyprotein2.7.7.490.511
2opsHBQGag-Pol polyprotein2.7.7.490.510
3megT27Gag-Pol polyprotein2.7.7.490.509
1tkxGWBGag-Pol polyprotein2.7.7.490.506
3lanKBTGag-Pol polyprotein2.7.7.490.502
1hquHBYGag-Pol polyprotein2.7.7.490.501
2vg5NNCGag-Pol polyprotein2.7.7.490.499
4ig3T27Gag-Pol polyprotein2.7.7.490.499
4i2q1BTGag-Pol polyprotein2.7.7.490.497
2hndNVPGag-Pol polyprotein2.7.7.490.493
1s1tUC1Gag-Pol polyprotein2.7.7.490.491
1rt7UC4Gag-Pol polyprotein2.7.7.490.490
2opqHBQGag-Pol polyprotein2.7.7.490.490
1jlaTNKGag-Pol polyprotein2.7.7.490.485
3dleGFAGag-Pol polyprotein2.7.7.490.481
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.479
2hnzPC0Gag-Pol polyprotein2.7.7.490.479
1dajMOTDihydrofolate reductase1.5.1.30.477
5cyqT27Gag-Pol polyprotein2.7.7.490.476
1o5rFR9Adenosine deaminase3.5.4.40.474
3p9tTCLRepressor/0.473
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.473
3nbpJGZGag-Pol polyprotein2.7.7.490.472
4ii5ADPCyclin-dependent kinase 22.7.11.220.472
1hniAAAGag-Pol polyprotein2.7.7.490.471
1jlqSBNGag-Pol polyprotein2.7.7.490.471
2cciATPCyclin-dependent kinase 22.7.11.220.471
3mec65BGag-Pol polyprotein2.7.7.490.469
3med65BGag-Pol polyprotein2.7.7.490.468
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
3m8p65BGag-Pol polyprotein2.7.7.490.465
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
1jlgUC1Gag-Pol polyprotein2.7.7.490.463
2fzhDH1Dihydrofolate reductase1.5.1.30.463
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.463
4jlj1NMDeoxycytidine kinase2.7.1.740.462
3cd2MTXDihydrofolate reductase1.5.1.30.461
1klmSPPGag-Pol polyprotein2.7.7.490.459
1yc2NADNAD-dependent protein deacylase 2/0.458
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3lalKRVGag-Pol polyprotein2.7.7.490.458
3m8qDJZGag-Pol polyprotein2.7.7.490.458
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.457
3uzaT4GAdenosine receptor A2a/0.457
1qxlFR8Adenosine deaminase3.5.4.40.456
4elb34RDihydrofolate reductase/0.456
1ju6LYAThymidylate synthase2.1.1.450.455
3oafOAGDihydrofolate reductase1.5.1.30.455
4elf35IDihydrofolate reductase/0.455
4zvmDM2Ribosyldihydronicotinamide dehydrogenase [quinone]/0.455
1c1c612Gag-Pol polyprotein2.7.7.490.454
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.454
2oppHBQGag-Pol polyprotein2.7.7.490.454
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.454
3td8D2RDihydrofolate reductase1.5.1.30.454
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
3ctj320Hepatocyte growth factor receptor2.7.10.10.453
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4iw8KN3Estrogen receptor/0.453
4nb6444Nuclear receptor ROR-gamma/0.453
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
1uymPU3Heat shock protein HSP 90-beta/0.451
4a862ANMajor pollen allergen Bet v 1-A/0.451
4elg52JDihydrofolate reductase/0.451
4ogrADNCyclin-dependent kinase 92.7.11.220.451
1umlFR4Adenosine deaminase3.5.4.40.450
1v7aFRCAdenosine deaminase3.5.4.40.450
2tscCB3Thymidylate synthase/0.450
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1jlcFTCGag-Pol polyprotein2.7.7.490.449
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2hb8MVDVitamin D3 receptor/0.449
2ic3HBYGag-Pol polyprotein2.7.7.490.449
3rak03ZCyclin-dependent kinase 22.7.11.220.449
3s7a684Dihydrofolate reductase1.5.1.30.449
4o761M3Bromodomain-containing protein 4/0.449
1ezfIN0Squalene synthase2.5.1.210.448
1f4gTP4Thymidylate synthase/0.448
3e5aVX6Aurora kinase A2.7.11.10.448
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
5cvfATPCasein kinase II subunit alpha2.7.11.10.448
1x8lOXRRetinol dehydratase/0.447
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.447
3kpzZNEVitamin D3 receptor/0.447
2fvdLIACyclin-dependent kinase 22.7.11.220.446
4a87NARMajor pollen allergen Bet v 1-A/0.446
1aoeGW3Dihydrofolate reductase1.5.1.30.445
1hvyD16Thymidylate synthase2.1.1.450.445
1mvtDTMDihydrofolate reductase1.5.1.30.445
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3eel53TUncharacterized protein/0.445
3g70A5TRenin3.4.23.150.445
3m0eATPTranscriptional regulator (NtrC family)/0.445
3ol5SAWCamphor 5-monooxygenase1.14.15.10.445
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
1ie9VDXVitamin D3 receptor/0.444
1mvsDTMDihydrofolate reductase1.5.1.30.444
1osvCHCBile acid receptor/0.444
1s3vTQDDihydrofolate reductase1.5.1.30.444
3fl8RARDihydrofolate reductase/0.444
3hz5Z64Heat shock protein HSP 90-alpha/0.444
2c7xNRBCytochrome P450 monooxygenase PikC/0.443
2oprHBQGag-Pol polyprotein2.7.7.490.443
2p15EZTEstrogen receptor/0.443
3eej53RUncharacterized protein/0.443
3juhANPCasein kinase II subunit alpha2.7.11.10.443
3jwcEKBDihydrofolate reductase/0.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bcmT7ZCyclin-dependent kinase 22.7.11.220.443
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4ixeIXEDihydrofolate reductase1.5.1.30.443
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
2k5tCOAPanD regulatory factor/0.442
3ix9MTXDihydrofolate reductase1.5.1.30.442
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4iwyADPRibosomal protein S6--L-glutamate ligase/0.442
5cccDDFDihydrofolate reductase1.5.1.30.442
3rfmCFFAdenosine receptor A2a/0.442
1uyhPU0Heat shock protein HSP 90-alpha/0.441
1xzqFONtRNA modification GTPase MnmE3.6.50.441
2bxoOPBSerum albumin/0.441
2hw1ANPKetohexokinase/0.441
2vwz7X6Ephrin type-B receptor 42.7.10.10.441
3abaFLICytochrome P450/0.441
3qlxQLRUncharacterized protein/0.441
4ele31IDihydrofolate reductase/0.441
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1ek2CDUBifunctional epoxide hydrolase 2/0.440
1upw444Oxysterols receptor LXR-beta/0.440
3frfXCFDihydrofolate reductase1.5.1.30.440
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3s1h56ZCyclin-dependent kinase 22.7.11.220.440
3sh25DRDihydrofolate reductase1.5.1.30.440
3srrQ20Dihydrofolate reductase1.5.1.30.440
4ddrMMVDihydrofolate reductase1.5.1.30.440
4e37NDPCatalase1.11.1.60.440
4iui1GQEstrogen receptor/0.440