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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bakAQZMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2bakAQZMitogen-activated protein kinase 14/1.000
4a9yAQZMitogen-activated protein kinase 14/1.000
3hv3R49Mitogen-activated protein kinase 14/0.574
3gcq1BUMitogen-activated protein kinase 14/0.573
3lfeZ84Mitogen-activated protein kinase 14/0.560
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.548
3lfcZ86Mitogen-activated protein kinase 14/0.537
3l8sBFFMitogen-activated protein kinase 14/0.529
3iw8HIZMitogen-activated protein kinase 14/0.519
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.516
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.511
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.510
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.506
2ewaSB2Mitogen-activated protein kinase 14/0.505
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.500
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.499
3bi6396Wee1-like protein kinase2.7.10.20.496
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.491
3cr0809Wee1-like protein kinase2.7.10.20.488
1x8b824Wee1-like protein kinase2.7.10.20.485
4b2gV1NUncharacterized protein/0.484
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.483
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.482
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.481
1w83L11Mitogen-activated protein kinase 14/0.475
1crbRTLRetinol-binding protein 1/0.473
3gc9B45Mitogen-activated protein kinase 112.7.11.240.473
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.473
2z2w770Wee1-like protein kinase2.7.10.20.472
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.471
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.471
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.470
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.470
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.470
4bj9UHBTankyrase-22.4.2.300.470
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.468
2vwu7X1Ephrin type-B receptor 42.7.10.10.467
4gk3L87Ephrin type-A receptor 32.7.10.10.467
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.466
1tduCB3Thymidylate synthase/0.466
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.466
4eevL1XHepatocyte growth factor receptor2.7.10.10.466
2p33J07Mitogen-activated protein kinase 102.7.11.240.465
3ctj320Hepatocyte growth factor receptor2.7.10.10.465
3tubFPUTyrosine-protein kinase SYK2.7.10.20.463
3zewSTUEphrin type-B receptor 42.7.10.10.463
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
2wi72KLHeat shock protein HSP 90-alpha/0.462
2gtnLIEMitogen-activated protein kinase 14/0.461
4eh60ONMitogen-activated protein kinase 14/0.461
1f4gTP4Thymidylate synthase/0.459
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.459
3eta351Insulin receptor2.7.10.10.459
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.458
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.458
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.458
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.457
2owb626Serine/threonine-protein kinase PLK12.7.11.210.457
4iaq2GM5-hydroxytryptamine receptor 1B/0.457
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2in6839Wee1-like protein kinase2.7.10.20.456
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.456
3nxoD2BDihydrofolate reductase1.5.1.30.456
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.455
2y6o1N1Ephrin type-A receptor 42.7.10.10.455
3ft8MOJHeat shock protein HSP 90-alpha/0.455
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.455
4h1e10JBeta-secretase 13.4.23.460.455
1w06W05Isopenicillin N synthase1.21.3.10.454
3q44D50M1 family aminopeptidase3.4.110.454
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.454
4nh82LCHeat shock protein HSP 90-alpha/0.454
4orkGDPBifunctional AAC/APH2.3.10.454
2bktRPFRenin3.4.23.150.453
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.453
3itzP66Mitogen-activated protein kinase 14/0.453
1n71COAAac(6')-Ii protein/0.452
1pmn984Mitogen-activated protein kinase 102.7.11.240.452
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.452
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.451
1yw2PGJMitogen-activated protein kinase 14/0.451
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.451
3bhlTHGThymidylate synthase/0.451
3vjoANPEpidermal growth factor receptor2.7.10.10.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.451
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4l9kEHFSerum albumin/0.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.450
2ij7TPFMycocyclosin synthase1.14.21.90.450
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.450
3cth319Hepatocyte growth factor receptor2.7.10.10.450
3rsv3RSBeta-secretase 13.4.23.460.450
4eh3NARMitogen-activated protein kinase 14/0.450
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3d4bDZDNAD-dependent protein deacetylase/0.449
3s4qNK0Mitogen-activated protein kinase 14/0.449
3uibSB2Putative mitogen-activated protein kinase/0.449
5f54TMPSingle-stranded-DNA-specific exonuclease/0.449
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.448
3rthRTHBeta-secretase 13.4.23.460.448
4anqVGHALK tyrosine kinase receptor2.7.10.10.448
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
3reyXACAdenosine receptor A2a/0.448
1o5rFR9Adenosine deaminase3.5.4.40.447
2ghmLICMitogen-activated protein kinase 14/0.447
2xvdAS6Ephrin type-B receptor 42.7.10.10.447
3g6zA7TRenin3.4.23.150.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4hni16WCasein kinase I isoform epsilon2.7.11.10.447
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.447
1hb1OCVIsopenicillin N synthase1.21.3.10.446
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
2excJNKMitogen-activated protein kinase 102.7.11.240.446
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2x7hPFNProstaglandin reductase 310.446
2yn8STUEphrin type-B receptor 42.7.10.10.446
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.446
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1qiqACCIsopenicillin N synthase1.21.3.10.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.445
2vx17X8Ephrin type-B receptor 42.7.10.10.445
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.445
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3pqbVGPPutative oxidoreductase/0.445
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4equG6ISerine/threonine-protein kinase 102.7.11.10.445
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.445
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.445
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.445
1dr3HBIDihydrofolate reductase1.5.1.30.444
1pkfEPDEpothilone C/D epoxidase1.140.444
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2bu9HFVIsopenicillin N synthase1.21.3.10.444
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.444
2pl0STITyrosine-protein kinase Lck2.7.10.20.444
3gc8B45Mitogen-activated protein kinase 112.7.11.240.444
3hl0NADMaleylacetate reductase/0.444
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.444
3vs1VSATyrosine-protein kinase HCK2.7.10.20.444
5dp2NAPCurF/0.444
1s7gNADNAD-dependent protein deacylase 2/0.443
2qocANPEphrin type-A receptor 32.7.10.10.443
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.443
3slkNDPPolyketide synthase extender module 2/0.443
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.443
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.443
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.443
4hyu1BKMitogen-activated protein kinase 82.7.11.240.443
4jbtASDCytochrome P450 monooxygenase/0.443
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.443
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.10.443
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2henADPEphrin type-B receptor 22.7.10.10.442
3gu83GUDeath-associated protein kinase 12.7.11.10.442
3gwfFADCyclohexanone monooxygenase/0.442
3p3zP3ZPutative cytochrome P450/0.442
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3vi7CBDHematopoietic prostaglandin D synthase/0.442
4fhd0TTSpore photoproduct lyase/0.442
4xq9NADHomospermidine synthase2.5.1.440.442
5e8xSTUTGF-beta receptor type-12.7.11.300.442
3qakUKAAdenosine receptor A2a/0.442
1f4fTP3Thymidylate synthase/0.441
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.441
2qoqANPEphrin type-A receptor 32.7.10.10.441
2vn0TDZCytochrome P450 2C8/0.441
2vwy7X5Ephrin type-B receptor 42.7.10.10.441
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.441
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.441
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
1blzACVIsopenicillin N synthase1.21.3.10.440
1bygSTUTyrosine-protein kinase CSK/0.440
1ouk084Mitogen-activated protein kinase 14/0.440
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.440
1tysDHFThymidylate synthase/0.440
1u4dDBQActivated CDC42 kinase 1/0.440
1uymPU3Heat shock protein HSP 90-beta/0.440
1xddAAYIntegrin alpha-L/0.440
2puiADPMethylthioribose kinase2.7.1.1000.440
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.440
2zb1GK4Mitogen-activated protein kinase 14/0.440
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.440
3ocgOCGMitogen-activated protein kinase 14/0.440
3ttiKBIMitogen-activated protein kinase 102.7.11.240.440
4a99MIYTetX family tetracycline inactivation enzyme/0.440
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.440
4k33ACPFibroblast growth factor receptor 32.7.10.10.440
5bt42LOBromodomain-containing protein 4/0.440