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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b9fADPMitogen-activated protein kinase FUS32.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b9fADPMitogen-activated protein kinase FUS32.7.11.241.000
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.666
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.652
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.536
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.522
1tvoFRZMitogen-activated protein kinase 12.7.11.240.514
4fv6E57Mitogen-activated protein kinase 12.7.11.240.511
4qnyANPMitogen activated protein kinase, putative/0.510
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.508
2y9qANPMitogen-activated protein kinase 12.7.11.240.506
3i60E86Mitogen-activated protein kinase 12.7.11.240.506
1qmzATPCyclin-dependent kinase 22.7.11.220.505
1jstATPCyclin-dependent kinase 22.7.11.220.504
4s33ANPMitogen-activated protein kinase 12.7.11.240.504
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.501
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.499
4ii5ADPCyclin-dependent kinase 22.7.11.220.494
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.493
3zh8C58Protein kinase C iota type2.7.11.130.493
4fmqANPMitogen-activated protein kinase 12.7.11.240.492
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.490
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.489
3bu5ATPInsulin receptor2.7.10.10.488
4xlvACPInsulin receptor2.7.10.10.488
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.486
4eomATPCyclin-dependent kinase 22.7.11.220.485
4fv9E71Mitogen-activated protein kinase 12.7.11.240.485
4h3qANPMitogen-activated protein kinase 12.7.11.240.485
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.484
4xj3GTPCyclic GMP-AMP synthase/0.484
3c4zADPRhodopsin kinase/0.482
4oauADP2-5A-dependent ribonuclease3.1.260.482
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.479
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.479
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.478
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4eooATPCyclin-dependent kinase 22.7.11.220.477
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.476
4k33ACPFibroblast growth factor receptor 32.7.10.10.474
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.473
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.473
4i3zADPCyclin-dependent kinase 22.7.11.220.472
5e92ANPTGF-beta receptor type-22.7.11.300.472
4ysjADPCalmodulin-like domain protein kinase/0.471
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.469
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.469
5dnrATPAurora kinase A2.7.11.10.469
4s32ANPMitogen-activated protein kinase 12.7.11.240.468
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.467
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.467
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.467
2qoqANPEphrin type-A receptor 32.7.10.10.466
1b39ATPCyclin-dependent kinase 22.7.11.220.465
1hckATPCyclin-dependent kinase 22.7.11.220.465
2pmlANPUncharacterized protein/0.465
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4riyADPEpidermal growth factor receptor2.7.10.10.465
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.464
2ojj82AMitogen-activated protein kinase 12.7.11.240.464
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.464
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.464
1j39UPGDNA beta-glucosyltransferase/0.463
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.463
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.463
3c50ADPRhodopsin kinase/0.462
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.461
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.461
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.460
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.460
4ji91M3Tyrosine-protein kinase JAK2/0.460
4jrnANPRhoptry kinase family protein/0.460
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.459
3t9eADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.459
1u54ACPActivated CDC42 kinase 1/0.458
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.458
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.458
2hog710Serine/threonine-protein kinase Chk12.7.11.10.458
4nifANPMitogen-activated protein kinase 12.7.11.240.458
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.458
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4s34ANPMitogen-activated protein kinase 12.7.11.240.457
1i44ACPInsulin receptor2.7.10.10.456
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
3sheI85MAP kinase-activated protein kinase 32.7.11.10.455
3tdvGDPGentamicin resistance protein/0.455
1b38ATPCyclin-dependent kinase 22.7.11.220.454
1nzdUPGDNA beta-glucosyltransferase/0.454
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.453
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.453
2w17I19Cyclin-dependent kinase 22.7.11.220.453
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4i5cC5ITyrosine-protein kinase JAK1/0.453
4ki8ADP60 kDa chaperonin/0.453
4qmlANPSerine/threonine-protein kinase 242.7.11.10.453
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.452
3c4wATPRhodopsin kinase/0.452
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
5cnnANPEpidermal growth factor receptor2.7.10.10.452
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.451
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.451
4ivb1J5Tyrosine-protein kinase JAK1/0.451
1g5sI17Cyclin-dependent kinase 22.7.11.220.450
3ggfGVDSerine/threonine-protein kinase 26/0.450
3nieANPMitogen-activated protein kinase/0.450
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.450
4jr7GNPCasein kinase II subunit alpha2.7.11.10.450
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
3oroAGSSerine/threonine protein kinase/0.449
3w16P9JAurora kinase A2.7.11.10.449
4hge15VTyrosine-protein kinase JAK2/0.449
4o0uADNAurora kinase A2.7.11.10.449
2vtqLZACyclin-dependent kinase 22.7.11.220.448
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.448
3nszANPCasein kinase II subunit alpha2.7.11.10.448
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.448
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.448
1e9hINRCyclin-dependent kinase 22.7.11.220.447
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.447
2vv9IM9Cyclin-dependent kinase 22.7.11.220.447
4btjATPTau-tubulin kinase 12.7.11.10.447
4lyn1YGCyclin-dependent kinase 22.7.11.220.447
4o1pANPRibonuclease L/0.447
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.446
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.446
2henADPEphrin type-B receptor 22.7.10.10.446
3oriAGSSerine/threonine protein kinase/0.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.446
1cm8ANPMitogen-activated protein kinase 12/0.445
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.445
3lu7IPXSerum albumin/0.445
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4utdACPAurora kinase A2.7.11.10.445
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.444
3k3bADPKinesin-like protein KIF11/0.444
4bbe3O4Tyrosine-protein kinase JAK2/0.444
4ez50RSCyclin-dependent kinase 62.7.11.220.444
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.444
4fvqATPTyrosine-protein kinase JAK2/0.444
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.443
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.443
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.443
4e4l0NHTyrosine-protein kinase JAK1/0.443
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
4ix5ANPUncharacterized protein/0.443
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.443
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.443
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.442
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.442
4ic7ANPMitogen-activated protein kinase 72.7.11.240.442
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1ig1ANPDeath-associated protein kinase 12.7.11.10.441
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.441
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.441
2wtkANPSTE20-related kinase adapter protein alpha/0.441
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3w551FMMitogen-activated protein kinase 12.7.11.240.441
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.441
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.440
2j0lANPFocal adhesion kinase 12.7.10.20.440
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
4ehzJAKTyrosine-protein kinase JAK1/0.440
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.440