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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b5vNAPGlucose 1-dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b5vNAPGlucose 1-dehydrogenase/1.000
2vwpNDPGlucose 1-dehydrogenase/0.644
2vwqNAPGlucose 1-dehydrogenase/0.577
2vwhNAPGlucose 1-dehydrogenase/0.497
1pl8NADSorbitol dehydrogenase1.1.1.140.486
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.468
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.466
3el01UNGag-Pol polyprotein3.4.23.160.459
3mvl38PMitogen-activated protein kinase 14/0.458
1k6tXN1Gag-Pol polyprotein3.4.23.160.457
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.457
4dlj6RGMitogen-activated protein kinase 14/0.457
1me8RVPInosine-5'-monophosphate dehydrogenase/0.455
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3r1sX73Cyclin-dependent kinase 22.7.11.220.455
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.451
2eauCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.450
4j95ACPFibroblast growth factor receptor 2/0.450
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
4cdmFADDeoxyribodipyrimidine photolyase/0.447
3hazFADBifunctional protein PutA/0.445
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1phePIYCamphor 5-monooxygenase1.14.15.10.444
3nmhPYVAbscisic acid receptor PYL2/0.444
3zokNAD3-dehydroquinate synthase, chloroplastic4.2.3.40.444
2xclANPPhosphoribosylamine--glycine ligase/0.443
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.443
1hpoUNIGag-Pol polyprotein3.4.23.160.442
1iwiCAMCamphor 5-monooxygenase1.14.15.10.441
1me7RVPInosine-5'-monophosphate dehydrogenase/0.441
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2qnqQN3Gag-Pol polyprotein3.4.23.160.441
2r43G3GGag-Pol polyprotein3.4.23.160.441
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.440
2iw84SPCyclin-dependent kinase 22.7.11.220.440
4ejmNAPPutative zinc-binding dehydrogenase/0.440