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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b53D23Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b53D23Cyclin-dependent kinase 22.7.11.221.000
2w06FRVCyclin-dependent kinase 22.7.11.220.554
3lfqA28Cyclin-dependent kinase 22.7.11.220.533
2r3lSCWCyclin-dependent kinase 22.7.11.220.511
3le62BZCyclin-dependent kinase 22.7.11.220.499
1oirHDYCyclin-dependent kinase 22.7.11.220.497
2r3jSCJCyclin-dependent kinase 22.7.11.220.497
3r83Z14Cyclin-dependent kinase 22.7.11.220.496
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.494
2vttLZDCyclin-dependent kinase 22.7.11.220.494
3dogNNNCyclin-dependent kinase 22.7.11.220.493
4bgh3I6Cyclin-dependent kinase 22.7.11.220.493
2c6lDT4Cyclin-dependent kinase 22.7.11.220.491
1y91CT9Cyclin-dependent kinase 22.7.11.220.489
2a0cCK9Cyclin-dependent kinase 22.7.11.220.488
1ke7LS3Cyclin-dependent kinase 22.7.11.220.483
3lfnA27Cyclin-dependent kinase 22.7.11.220.482
2c6o4SPCyclin-dependent kinase 22.7.11.220.481
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.480
3s2pPMUCyclin-dependent kinase 22.7.11.220.480
2uznC96Cyclin-dependent kinase 22.7.11.220.478
4fkr45KCyclin-dependent kinase 22.7.11.220.477
3r7uX96Cyclin-dependent kinase 22.7.11.220.475
4ek816KCyclin-dependent kinase 22.7.11.220.475
2ds11CDCyclin-dependent kinase 22.7.11.220.474
2r64740Cyclin-dependent kinase 22.7.11.220.473
2a4lRRCCyclin-dependent kinase 22.7.11.220.470
2r3kSCQCyclin-dependent kinase 22.7.11.220.470
1aq1STUCyclin-dependent kinase 22.7.11.220.469
1pxlCK4Cyclin-dependent kinase 22.7.11.220.468
2r3p3SCCyclin-dependent kinase 22.7.11.220.468
4fkv61KCyclin-dependent kinase 22.7.11.220.467
4fklCK2Cyclin-dependent kinase 22.7.11.220.465
4fks46KCyclin-dependent kinase 22.7.11.220.463
3r7iX9ICyclin-dependent kinase 22.7.11.220.462
1w0xOLOCyclin-dependent kinase 22.7.11.220.461
1pxpCK8Cyclin-dependent kinase 22.7.11.220.460
3r7yZ04Cyclin-dependent kinase 22.7.11.220.460
3nynSGVG protein-coupled receptor kinase 62.7.11.160.459
1pxoCK7Cyclin-dependent kinase 22.7.11.220.458
2uzoC62Cyclin-dependent kinase 22.7.11.220.457
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
1oguST8Cyclin-dependent kinase 22.7.11.220.456
3fz1B98Cyclin-dependent kinase 22.7.11.220.456
4acm7YGCyclin-dependent kinase 22.7.11.220.456
2r3iSCFCyclin-dependent kinase 22.7.11.220.454
1gii1PUCyclin-dependent kinase 22.7.11.220.453
2vtqLZACyclin-dependent kinase 22.7.11.220.453
3sqq99ZCyclin-dependent kinase 22.7.11.220.453
3r7vZ02Cyclin-dependent kinase 22.7.11.220.452
3rmf20ZCyclin-dependent kinase 22.7.11.220.452
3rni21ZCyclin-dependent kinase 22.7.11.220.452
3s1h56ZCyclin-dependent kinase 22.7.11.220.452
1bwsNDPGDP-L-fucose synthase/0.451
1ykr628Cyclin-dependent kinase 22.7.11.220.451
2c5yMTWCyclin-dependent kinase 22.7.11.220.451
2vtsLZCCyclin-dependent kinase 22.7.11.220.451
3pj8404Cyclin-dependent kinase 22.7.11.220.451
1ke6LS2Cyclin-dependent kinase 22.7.11.220.450
3lfsA07Cyclin-dependent kinase 22.7.11.220.450
3qqlX03Cyclin-dependent kinase 22.7.11.220.450
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
2vthLZ2Cyclin-dependent kinase 22.7.11.220.449
2bhhRYUCyclin-dependent kinase 22.7.11.220.448
1g5sI17Cyclin-dependent kinase 22.7.11.220.447
2w17I19Cyclin-dependent kinase 22.7.11.220.447
3r8lZ30Cyclin-dependent kinase 22.7.11.220.447
4fkq42KCyclin-dependent kinase 22.7.11.220.447
3sw418KCyclin-dependent kinase 22.7.11.220.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.445
3r8vZ62Cyclin-dependent kinase 22.7.11.220.445
3wblPDYCyclin-dependent kinase 22.7.11.220.445
3rpo24ZCyclin-dependent kinase 22.7.11.220.444
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4fko20KCyclin-dependent kinase 22.7.11.220.443
2c6kDT2Cyclin-dependent kinase 22.7.11.220.442
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.442
1pxmCK5Cyclin-dependent kinase 22.7.11.220.441
1gih1PUCyclin-dependent kinase 22.7.11.220.440
2c6iDT1Cyclin-dependent kinase 22.7.11.220.440
3hmm855TGF-beta receptor type-12.7.11.300.440