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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.100

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1001.000
1ipeNDPTropinone reductase 21.1.1.2360.575
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.571
3f1kNAPUncharacterized oxidoreductase YciK10.562
2c29NAPDihydroflavonol 4-reductase/0.548
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.545
4dbzNDPPutative ketoacyl reductase1.3.10.543
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.543
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.542
5jlaNADPutative short-chain dehydrogenase/reductase/0.541
1ae1NAPTropinone reductase 1/0.538
4j7xNAPSepiapterin reductase1.1.1.1530.537
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.533
4yaiNAIC alpha-dehydrogenase/0.533
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.530
4j7uNAPSepiapterin reductase1.1.1.1530.530
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.527
4dc0NDPPutative ketoacyl reductase1.3.10.527
4hwkNAPSepiapterin reductase1.1.1.1530.527
4yagNAIC alpha-dehydrogenase/0.527
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.525
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.523
1n5dNDPCarbonyl reductase [NADPH] 1/0.519
3toxNAPPutative oxidoreductase/0.519
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.517
2dteNAIGlucose 1-dehydrogenase related protein/0.515
3d3wNAPL-xylulose reductase1.1.1.100.514
3autNAIGlucose 1-dehydrogenase 41.1.1.470.513
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.512
1x7gNAPPutative ketoacyl reductase1.3.10.509
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.509
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.509
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.508
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.508
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.507
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.505
4hxyNDPPlm1/0.504
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.504
2bd0NAPSepiapterin reductase/0.501
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.501
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.500
1g6kNADGlucose 1-dehydrogenase1.1.1.470.499
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.499
1pr9NAPL-xylulose reductase1.1.1.100.498
3s55NADPutative short-chain dehydrogenase/reductase/0.497
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.497
4gh5NADShort-chain dehydrogenase/reductase SDR/0.496
3gy0NAPNAD(P)-dependent oxidoreductase/0.495
3lqfNADGalactitol dehydrogenase/0.495
4qecNAPElxO/0.494
1oaaNAPSepiapterin reductase1.1.1.1530.492
4k6fNAPPutative Acetoacetyl-CoA reductase/0.491
4nbwNADShort-chain dehydrogenase/reductase SDR/0.491
3wdsNADNADH-dependent quinuclidinone reductase/0.490
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.490
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.489
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.488
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.487
3sx2NADUncharacterized protein/0.487
1iy8NADLevodione reductase/0.486
5ig2NADShort-chain dehydrogenase/reductase SDR/0.486
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.485
1x7hNDPPutative ketoacyl reductase1.3.10.484
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.484
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.483
5jydNADShort chain dehydrogenase/0.483
3o26NDPSalutaridine reductase/0.482
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.481
2yutNAPPutative short-chain oxidoreductase/0.481
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.479
1rwbNADGlucose 1-dehydrogenase1.1.1.470.479
3l77NJPShort-chain alcohol dehydrogenase/0.479
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.479
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.479
1dhrNADDihydropteridine reductase1.5.1.340.478
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
4dc1NDPPutative ketoacyl reductase1.3.10.477
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.476
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.476
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.476
3ai3NDPNADPH-sorbose reductase/0.475
3ak4NADNADH-dependent quinuclidinone reductase/0.475
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.475
3uxyNADShort-chain dehydrogenase/reductase SDR/0.474
5jy1NADPutative short-chain dehydrogenase/reductase/0.473
1zemNADXylitol dehydrogenase/0.472
4ure1PSCyclohexanol dehydrogenase/0.470
1t2cNAIL-lactate dehydrogenase1.1.1.270.468
1gcoNADGlucose 1-dehydrogenase1.1.1.470.467
2p5uNADUDP-glucose 4-epimerase/0.467
2xx91NFGlutamate receptor 2/0.467
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.467
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.466
4kwhNAPReductase homolog/0.466
1geeNADGlucose 1-dehydrogenase1.1.1.470.465
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
3d84NDPDihydrofolate reductase1.5.1.30.465
1i3lNADUDP-glucose 4-epimerase/0.464
4bb3KKAIsopenicillin N synthase1.21.3.10.464
1bwsNDPGDP-L-fucose synthase/0.463
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
3b70NAPEnoyl reductase LovC10.463
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.462
2ztuNADD(-)-3-hydroxybutyrate dehydrogenase/0.462
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.462
4u7wNDPMxaA/0.462
4fn4NADShort chain dehydrogenase/0.461
4esoNAPPutative oxidoreductase/0.460
1xddAAYIntegrin alpha-L/0.459
2a94AP0L-lactate dehydrogenase1.1.1.270.459
3ad9NADSubunit alpha of sarocosine oxidase/0.459
3mjeNDPAmphB/0.459
3qrwNDPPutative ketoacyl reductase1.3.10.459
3qwbNDPProbable quinone oxidoreductase1.6.5.50.459
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.458
1kvrNADUDP-glucose 4-epimerase5.1.3.20.458
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.458
4b8wNAPGDP-L-fucose synthase1.1.1.2710.458
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.458
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.457
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.456
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.456
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.456
1f8fNADBenzyl alcohol dehydrogenase/0.455
1ma0NADAlcohol dehydrogenase class-31.1.1.10.455
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.455
4l4xNDPAmphI/0.454
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.453
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.453
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
1hb3SCVIsopenicillin N synthase1.21.3.10.452
2yy7NADL-threonine dehydrogenase/0.452
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.452
4tm0FADKtzI/0.452
1ds7FMNOxygen-insensitive NAD(P)H nitroreductase/0.451
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.451
1nahNADUDP-glucose 4-epimerase5.1.3.20.450
3rj9NADAlcohol dehydrogenase1.1.1.10.450
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.450
4yvz3ATDNA integrity scanning protein DisA/0.450
1b16NAQAlcohol dehydrogenase1.1.1.10.449
1naiNADUDP-glucose 4-epimerase5.1.3.20.449
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.449
3bg7FADPyranose 2-oxidase/0.449
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.449
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.449
4xg1LLPDiaminopimelate decarboxylase/0.449
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.448
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.448
1hb1OCVIsopenicillin N synthase1.21.3.10.447
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.447
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.447
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.446
2givACOHistone acetyltransferase KAT8/0.446
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.446
2rirNAPDipicolinate synthase subunit A/0.446
3atzFMNProstaglandin F2a synthase/0.446
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.445
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
2rcyNAPPyrroline-5-carboxylate reductase/0.444
3qlrNDPDihydrofolate reductase1.5.1.30.444
3tscNADUncharacterized protein/0.444
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.444
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.444
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.444
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.443
2jb4A14Isopenicillin N synthase1.21.3.10.443
2oapANPType II secretion system protein (GspE-2)/0.443
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.443
2vwqNAPGlucose 1-dehydrogenase/0.443
2x7hPFNProstaglandin reductase 310.443
3orfNADDihydropteridine reductase1.5.1.340.443
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.443
3widNAPGlucose 1-dehydrogenase/0.443
1mjbACOHistone acetyltransferase ESA1/0.442
1tehNADAlcohol dehydrogenase class-31.1.1.10.442
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.442
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.442
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.442
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.442
4u0mGTPCyclic GMP-AMP synthase/0.442
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.442
4l1xNAPAldo-keto reductase family 1 member C2/0.441
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.441
2g1n1IGRenin3.4.23.150.440
2iviACWIsopenicillin N synthase1.21.3.10.440
2ou2ACOHistone acetyltransferase KAT5/0.440
3zeiAWHO-acetylserine sulfhydrylase/0.440
4bfxZVXPantothenate kinase2.7.1.330.440
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.440
4lcjNADC-terminal-binding protein 2/0.440