sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ayr | L4G | Estrogen receptor |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ayr | L4G | Estrogen receptor | / | 1.000 | |
| 3ert | OHT | Estrogen receptor | / | 0.475 | |
| 5aqz | SGV | Heat shock 70 kDa protein 1A | / | 0.470 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.467 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.465 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.465 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 4l9q | 9TP | Serum albumin | / | 0.459 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.456 | |
| 3gue | UPG | UTP-glucose-1-phosphate uridylyltransferase 2, putative | / | 0.452 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.447 | |
| 1syn | F89 | Thymidylate synthase | / | 0.446 | |
| 3fzf | ATP | Heat shock cognate 71 kDa protein | / | 0.446 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2lbv | EB4 | Extracellular fatty acid-binding protein | / | 0.445 | |
| 2mjp | ANP | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.445 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.444 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.443 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.443 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.441 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.441 |