sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 1.000 | |
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.673 | |
| 1eqh | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.670 | |
| 4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.663 | |
| 1eqg | IBP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.648 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.629 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.629 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.625 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.620 | |
| 3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.606 | |
| 1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.604 | |
| 3n8x | NIM | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.600 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.595 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.592 | |
| 1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.587 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.587 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.586 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.579 | |
| 2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.562 | |
| 3ln0 | 52B | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.559 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.559 | |
| 4rrx | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.544 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.541 | |
| 3kk6 | CEL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.525 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.511 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.507 | |
| 3n8y | DIF | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.499 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.497 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.497 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.491 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.490 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.488 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.488 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.487 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.487 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.486 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.477 | |
| 1ht5 | FL2 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.477 | |
| 1pxx | DIF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.476 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.476 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.475 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.475 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.474 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.473 | |
| 5ikt | TLF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.473 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.471 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.471 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.471 | |
| 1cx2 | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.470 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.470 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.470 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2ibz | SMA | Cytochrome b | / | 0.469 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.469 | |
| 4eb4 | D16 | Thymidylate synthase | 2.1.1.45 | 0.469 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.468 | |
| 4b14 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.468 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.466 | |
| 3eej | 53R | Uncharacterized protein | / | 0.466 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.464 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.463 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.463 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3qly | 55V | Uncharacterized protein | / | 0.462 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.462 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.462 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.461 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.460 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.460 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1efp | FAD | Electron transfer flavoprotein subunit alpha | / | 0.459 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.459 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.458 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.458 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.458 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.457 | |
| 3lu7 | IPX | Serum albumin | / | 0.457 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4iae | 1DX | Alr2278 protein | / | 0.457 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.456 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.456 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.455 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2oxt | SAM | Genome polyprotein | / | 0.455 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.455 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.455 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.455 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3q8x | UD1 | Toxin zeta | / | 0.455 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.455 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.455 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.454 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.454 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.454 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.454 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4eaj | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.454 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.453 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.453 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.453 | |
| 5dp2 | NAP | CurF | / | 0.453 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.452 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.452 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.452 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.452 | |
| 1kyo | SMA | Cytochrome b | / | 0.451 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.451 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.451 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.451 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.451 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.451 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.451 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.451 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.450 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.450 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.450 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.449 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.449 | |
| 3cxh | SMA | Cytochrome b | / | 0.449 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.449 | |
| 4ccr | FAD | Thioredoxin reductase | / | 0.449 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.449 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 4xr9 | TMP | CalS8 | / | 0.449 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.448 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.448 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.448 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.448 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.448 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.448 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1kb9 | SMA | Cytochrome b | / | 0.447 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.447 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.447 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.447 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.447 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 3nxe | 2NC | Protease | / | 0.447 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.447 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.447 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.446 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.446 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.446 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.446 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.446 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.446 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 3stw | 2TD | Methylketone synthase I | / | 0.446 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.446 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.446 | |
| 4a28 | ADP | Kinesin-like protein KIF11 | / | 0.446 | |
| 4fox | D16 | Thymidylate synthase ThyA | / | 0.446 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.446 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 5l7d | CLR | Smoothened homolog | / | 0.446 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2a1u | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.445 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.445 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.445 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.445 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.445 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.445 | |
| 4a1z | ADP | Kinesin-like protein KIF11 | / | 0.445 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.445 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.445 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.445 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1u3r | 338 | Estrogen receptor beta | / | 0.444 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.444 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.444 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.444 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.444 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.444 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.444 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.444 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1ezv | SMA | Cytochrome b | / | 0.443 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.443 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.443 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.443 | |
| 1u0h | ONM | Adenylate cyclase type 2 | / | 0.443 | |
| 1u0h | ONM | Adenylate cyclase type 5 | / | 0.443 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.443 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.443 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.443 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2v1a | FMN | NPH1-1 | / | 0.443 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.443 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.443 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.443 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.443 | |
| 4xzm | NAP | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.443 | |
| 4z07 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.443 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.442 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.442 | |
| 2bx8 | AZQ | Serum albumin | / | 0.442 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.442 | |
| 2p15 | EZT | Estrogen receptor | / | 0.442 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.442 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.442 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.442 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.442 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.442 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4x2d | ATP | Fic family protein putative filamentation induced by cAMP protein | / | 0.442 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.442 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.441 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.441 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.441 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.441 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.441 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.441 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.441 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.441 | |
| 3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.441 | |
| 4b1f | KRH | Glutamate racemase | / | 0.441 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 | |
| 1jut | LYD | Thymidylate synthase | / | 0.440 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.440 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.440 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.440 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.440 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.440 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.440 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.440 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.440 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.440 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.440 |